LABORATORY OF FUNCTIONAL GENOMICS
PhD in Life Sciences, Université Pierre et Marie Curie (Paris VI), France (1991 – 1995)
MSc in Biotechnology, Université Pierre et Marie Curie (Paris VI), France (1989 – 1990)
Specialization in Gynecology, Faculty of Medicine, Udelar, Uruguay (1986 – 1988)
Doctor in Medicine, Faculty of Medicine, Udelar, Uruguay (1975 – 1985)
Current Academic Position: Tenured Professor at Basic Department of Medicine – Hospital de Clínicas – Faculty of Medicine (Udelar).
Small regulatory RNAs
Fromm, B; Kang, W; Rovira, C; Cayota, A; Witwer, KW; Friedländer, M and Tosar, J.P. (2018): Plant microRNAs in human sera are likely contaminants. Journal of Nutritional Biochemistry (In press).
Tosar, J.P., Gambaro, F., Darre, L., Pantano, S., Westhof, E. and Cayota, A. (2018) Dimerization confers increased stability to nucleases in 5′ halves from glycine and glutamic acid tRNAs. Nucleic Acids Res. gky495; doi: 10.1093/nar/gky495
Tosar, J.P., Rovira, C. and Cayota, A. (2018) Non-coding RNA fragments account for the majority of annotated piRNAs expressed in somatic non-gonadal tissues. Communications Biology, 1, 2.
Tosar, J.P. and Cayota, A. (2018) Detection and Analysis of Non-vesicular Extracellular RNA. Methods Mol Biol, 1740, 125-137.
Tosar, J.P., Cayota, A., Eitan, E., Halushka, M.K. and Witwer, K.W. (2017) Ribonucleic artefacts: are some extracellular RNA discoveries driven by cell culture medium components? J Extracell Vesicles, 6, 1272832.
Doldán, X., Fagúndez, P., Cayota, A., Laíz, J., Tosar, J.P. (2016) Electrochemical sandwich immunosensor for determination of exosomes based on surface marker-mediated signal amplification. Anal Chem, 88, 10466-10473
Tosar, J.P., Gambaro, F., Sanguinetti, J., Bonilla, B., Witwer, K.W. and Cayota, A. (2015) Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Res, 43, 5601-5616.
Cairoli, E., Danese, N., Teliz, M., Bruzzone, M.J., Ferreira, J., Rebella, M. and Cayota, A. (2015) Cumulative dose of hydroxychloroquine is associated with a decrease of resting heart rate in patients with systemic lupus erythematosus: a pilot study. Lupus, 24, 1204-1209.