Hugo Peluffo

Hugo Peluffo 2018-12-18T14:13:59+00:00

Neuroinflammation and Gene Therapy

  • BSc in Biological Science, Faculty of Science, Universidad de la República, Uruguay (1992-1998)

  • MSc in Biological Science, Faculty of Medicine, Universidad de la República, Uruguay (2000)

  • MSc in Neuroscience, Universidad Autónoma de Barcelona, Spain (2003)

  • PhD in Neurosciencie – Link to thesis, Universidad Autónoma de Barcelona, Spain (2001-2006).

  • Neuroinflamation

  • Microglia

  • Gene Therapy

  • Neurotrauma

  • Immunoreceptors

  • Major depression

  • 1. H. Peluffo, A. G. Estévez, L. Barbeito y J. M. Stutzman. Riluzole promotes survival of rat motorneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers. Neuroscience Letters 228:207-211 (1997).

  • 2. P. Cassina*, H. Peluffo*, M. Pehar, L. Martínez-Palma, A. Ressia, J. S. Beckman, A. Estévez y L. Barbeito. Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J. Neurosci. Res. 67:21-29 (2001). *Ambos autores contribuyeron igualmente a este trabajo.

  • 3. Peluffo, H. * Arís, A. Acarin, L. González, B. Villaverde, A. and Castellano, B. Non-viral gene delivery to the CNS based on a novel integrin targeting multifunctional protein. Human Gene Therapy 14:12-15 (2003). * Autor al que debe dirigirse la correspondencia.

  • 4. H. Peluffo*, P. González, A. Arís, L. Acarin*, A. Villaverde, B. Castellano, B. González. RGD domains neuroprotect the immature brain by a glial dependent mechanism. Annals of Neurology. 62:251-261 (2007). *Autores a los que debe dirigirse la correspondencia.

  • 5. Domingo-Espín, J., E. Vazquez, J. Ganz, O. Conchillo, E. García-Fruitós, J. Cedano, U. Unzueta, V. Petegnief, N. Gonzalez-Montalbán, A.M. Planas, X. Daura, H. Peluffo, N. Ferrer-Miralles, y A. Villaverde. The nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions. Nanomedicine. 6:1047-1061 (2011).

  • 6. Peluffo, H*; Alí-Ruiz, D; Ejarque-Ortíz, A; Heras-Alvarez, V; Comas-Casellas, E; Martínez-Barriocanal, A; Kamaid, A; Alvarez-Errico, D; Negro, ML; Lago, N; Schwartz S Jr; Villaverde, A; y Sayós, J. Overexpression of the immunoreceptor CD300f has a neuroprotective role in a model of acute brain injury. Brain Pathology (Epub 2011) 22:318-328 (2012). * Autor al que debe dirigirse la correspondencia.

  • 7. *Peluffo, H., *Foster, E., Ahmed, S.G., Lago, N., Hutson, T.H., Moon, L., Yip, P., Wanisch, K., Caraballo-Miralles, V., Olmos, G., Lladó, J., McMahon, S.B. and Yáñez-Muñoz, R.J. Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord. Gene Therapy 20:645-657, 2013. *Ambos autores contribuyeron igualmente al trabajo.

  • 8. Negro, M.L. P. Saccardo, C. Giacomini, R.J. Yáñez-Muñoz, N. Ferrer-Miralles, E. Vazquez, A. Villaverde and H, Peluffo*. Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Molecular Therapy – Methods & Clinical Development, 1:14047, 2014. *Autor al que debe dirigirse la correspondencia.

  • 9. Peluffo H*, Solari-Saquieres P*, Negro-Demontel ML, Francos-Quijorna I, Navarro X, López-Vales R, Sayós J, Lago N. CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype. J. Neuroinflammation, 12:145 (12 August) 2015. *Ambos autores contribuyeron igualmente al trabajo.

  • 10. Hugo Peluffo, Ugutz Unzueta, María Luciana Negro, Zhikun Xu, Esther Vazquez, Neus Ferrer-Miralles and Antonio Villaverde. BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS. Biotechnology Advances, 33(2):277-287, 2015

  • 11. Fernanda N. Kaufmann, Ana Paula Costa, Gabriele Ghisleni, Alexandre P. Diaz, Ana Lúcia Rodrigues, Hugo Peluffo, Manuella Pinto Kaster. NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings. Brain Behavior and Immunity, 64: 367-383, 2017.

  • 12. Natalia Lago, Bruno Pannunzio, Jesús Amo-Aparicio, Rubèn López-Vales and Hugo Peluffo. CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1. Brain Behaviour and Immunity Junio, 2018.