{"id":24849395,"date":"2024-11-21T11:25:12","date_gmt":"2024-11-21T14:25:12","guid":{"rendered":"https:\/\/pasteur.uy\/juan-pablo-tosar\/"},"modified":"2024-11-21T11:25:48","modified_gmt":"2024-11-21T14:25:48","slug":"juan-pablo-tosar","status":"publish","type":"page","link":"https:\/\/pasteur.uy\/en\/juan-pablo-tosar\/","title":{"rendered":"Juan Pablo Tosar"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; custom_margin_phone=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;||10px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;300ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Tosar-Juan-Pablo.jpg&#8221; title_text=&#8221;Tosar, Juan Pablo&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;|700|||||||&#8221; text_font_size=&#8221;21px&#8221; header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#005293&#8243; header_font_size=&#8221;39px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Juan Pablo Tosar<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"et_pb_member_position et-fb-editable-element et-fb-editable-element__editing\" data-shortcode-id=\"0.0.0.0-1643373697362\" data-quickaccess-id=\"position\" contenteditable=\"true\">Juan Pablo Tosar, PhD<\/p>\n<div data-shortcode-id=\"0.0.0.0-1643374141066\" data-quickaccess-id=\"body\" data-quickaccess-editable=\"yes\" class=\"et-fb-popover-tinymce\">\n<div class=\"mce-content-body\" contenteditable=\"true\" style=\"position: relative;\">\n<p>\n                <a href=\"mailto:aabin@pasteur.edu.uy\">jptosar@pasteur.edu.uy<\/a>\n              <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#ce8e00&#8243; divider_position=&#8221;center&#8221; divider_weight=&#8221;3px&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;7%&#8221; width_tablet=&#8221;13%&#8221; width_phone=&#8221;15%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_margin_tablet=&#8221;0px||0px||false|false&#8221; custom_margin_phone=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;|300||on|||||&#8221; text_font_size=&#8221;18px&#8221; max_width=&#8221;38%&#8221; max_width_tablet=&#8221;70%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|phone&#8221; custom_margin_tablet=&#8221;&#8221; custom_margin_phone=&#8221;||20px||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Functional Genomics Laboratory<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin_tablet=&#8221;&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;500ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; module_class=&#8221;df-buttons &#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_margin_tablet=&#8221;||0px||false|false&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; 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button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_text=&#8221;Research areas&#8221; button_alignment=&#8221;center&#8221; module_class=&#8221;dfc-areas df-button&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#005293&#8243; button_bg_color=&#8221;rgba(0,82,147,0.16)&#8221; button_border_width=&#8221;0px&#8221; button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_text=&#8221;Relevant publications&#8221; button_alignment=&#8221;center&#8221; module_class=&#8221;dfc-publicaciones df-button&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#005293&#8243; button_bg_color=&#8221;rgba(0,82,147,0.16)&#8221; button_border_width=&#8221;0px&#8221; button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;df-rows df-area dfc-educacion&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;15px||||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;600ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row module_class=&#8221;dfc-educacion&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>PhD in Biological Sciences. PEDECIBA (UdelaR &#8211; MEC) (2012 &#8211; 2016): &#8220;Small regulatory RNAs in the extracellular milieu: secretion, stability, transport and potential in intercellular communication&#8221;. <\/li>\n<li>Master in Biological Sciences, UdelaR (2009 &#8211; 2011).<\/li>\n<li>Degree in Biochemistry, Facultad de Ciencias, UdelaR (2004 &#8211; 2008).<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-areas&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>\n<div>Non-coding RNAs<\/div>\n<\/li>\n<li>\n<div>Extracellular RNA<\/div>\n<\/li>\n<li>\n<div>RNA biochemistry<\/div>\n<\/li>\n<li>\n<div>Analytical Biochemistry<\/div>\n<div><\/div>\n<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; ul_line_height=&#8221;1.7em&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Castellano M, Blanco V, Li Calzi M, Costa B, Witwer K, Hill M, Cayota A, Segovia M, Tosar JP (2024). Ribonuclease activity undermines immune sensing of naked extracellular RNA. BioRxiv pre-print. DOI: 10.1101\/2024.04.23.590771.   <\/li>\n<li>Tosar JP, Castellano M, Costa B, Cayota A (2024). Small RNA structural biochemistry in a post-sequencing era. Nature Protocols 19, 595-602.  <\/li>\n<li>Costa B, Li Calzi M, Castellano M, Blanco V, Cuevasanta E, Litvan I, Ivanov P, Witwer K, Cayota A, Tosar J.P. (2023). Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids. Proceedings of the National Academy of Sciences USA (PNAS) 120 (4), e2216330120.  <\/li>\n<li>Tosar, J.P.; Witwer, K.; Cayota, A. (2021) Revisiting extracellular RNA release, processing and function. Trends in Biochemical Sciences 46(6): 438-445.<\/li>\n<li>Tosar, J.P.; Segovia, M.; G\u00e1mbaro, F.; Akiyama, Y.; Fag\u00fandez, P.; Costa, B.; Possi, T.; Hill, M.; Ivanov, P.; Cayota, A. (2020) Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome. Nucleic Acids Research 48(22): 12874-12888.<\/li>\n<li>Tosar, J.P.; G\u00e1mbaro, F.; Darr\u00e9, L.; Pantano, S.; Westhof, E.; Cayota, A. (2018) Dimerization confers increased stability to nucleases in extracellular 5&#8242; halves from glycine and glutamic acid tRNAs. Nucleic Acids Research 46 (17): 9081-9093.<\/li>\n<li>Tosar J.P.; Rovira, C.; Cayota, A. (2018) Non-coding RNA fragments account for the majority of annotated piRNAs expressed in somatic non-gonadal tissues. Communications Biology 1, e2<\/li>\n<li>Dold\u00e1n, X; Fag\u00fandez, P.; Cayota, A.; La\u00edz, J.; Tosar, J.P. (2016) Electrochemical sandwich immunosensor for determination of exosomes based on surface marker-mediated signal amplification. Analytical Chemistry 88 (21): 10466-10473.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Juan Pablo TosarJuan Pablo Tosar, PhD jptosar@pasteur.edu.uy Functional Genomics Laboratory PhD in Biological Sciences. PEDECIBA (UdelaR &#8211; MEC) (2012 &#8211; 2016): &#8220;Small regulatory RNAs in the extracellular milieu: secretion, stability, transport and potential in intercellular communication&#8221;. Master in Biological Sciences, UdelaR (2009 &#8211; 2011). Degree in Biochemistry, Facultad de Ciencias, UdelaR (2004 &#8211; 2008). Non-coding [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":1989,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"dipi_cpt_category":[],"class_list":["post-24849395","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/24849395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=24849395"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/24849395\/revisions"}],"predecessor-version":[{"id":24849400,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/24849395\/revisions\/24849400"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media\/1989"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=24849395"}],"wp:term":[{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=24849395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}