{"id":24851069,"date":"2025-03-18T11:02:10","date_gmt":"2025-03-18T14:02:10","guid":{"rendered":"https:\/\/pasteur.uy\/heads-of-labs-and-units\/virginia-lopez\/"},"modified":"2025-03-18T11:03:02","modified_gmt":"2025-03-18T14:03:02","slug":"virginia-lopez","status":"publish","type":"page","link":"https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/virginia-lopez\/","title":{"rendered":"Virginia Lopez"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; 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header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#005293&#8243; header_font_size=&#8221;39px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Virginia L\u00f3pez<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"et_pb_member_position et-fb-editable-element et-fb-editable-element__editing\" data-shortcode-id=\"0.0.0.0-1643373697362\" data-quickaccess-id=\"position\" contenteditable=\"true\">Virginia L\u00f3pez, PhD<\/p>\n<div data-shortcode-id=\"0.0.0.0-1643374141066\" data-quickaccess-id=\"body\" data-quickaccess-editable=\"yes\" class=\"et-fb-popover-tinymce\">\n<div class=\"mce-content-body\" contenteditable=\"true\" style=\"position: relative;\">\n<p><a href=\"mailto:vlopez@pasteur.edu.uy\">vlopez@pasteur.edu.uy<\/a><\/p>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#ce8e00&#8243; 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custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Laboratory of Organic Synthesis<br \/>and Drug Development<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;500ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; module_class=&#8221;df-buttons &#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_margin_tablet=&#8221;||0px||false|false&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; 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_builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#005293&#8243; button_bg_color=&#8221;rgba(0,82,147,0.16)&#8221; button_border_width=&#8221;0px&#8221; button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;df-rows df-area dfc-educacion&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;15px||||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;600ms&#8221; global_colors_info=&#8221;{}&#8221; collapsed=&#8221;off&#8221;][et_pb_row module_class=&#8221;dfc-educacion&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>PhD in Chemistry, Universidad de la Rep\u00fablica, PEDECIBA-Qu\u00edmica, Uruguay, 2006.<\/li>\n<li>Pharmaceutical Chemist, Universidad de la Rep\u00fablica, Uruguay, 2002.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-patentes&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Varela, M.; L\u00f3pez, M.; Ingold, M.; Alem, D.; Perini, V.; Perelmuter, K.; Bollati-Fogol\u00edn, M.; L\u00f3pez, G.V.; Hern\u00e1ndez, P. New Nitric Oxide-Releasing Compounds as Promising Anti-Bladder Cancer Drugs. Biomedicines 2023, 11, 199. https:\/\/doi.org\/10.3390\/biomedicines11010199<\/li>\n<li>F. Ortiz, T. Tassano, M. Ingold, V. de la Sovera, A. Puerta, J.M. Padr\u00f3n, G.V. L\u00f3pez,* W. Porcal.* Greener approach for the synthesis of nitrovinylfurans from biomass-derived 5-hydroxymethyfurfural as selective antiproliferative agents. Sustain. Chem. Pharm. 2022, 30, 100828. https:\/\/doi.org\/10.1016\/j.scp.2022.100828<\/li>\n<li>M. Ingold, V. de la Sovera, R. Dapueto, W. Porcal,* G.V. L\u00f3pez.* Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions. Molecules 2022, 27(6), 1756; https:\/\/doi.org\/10.3390\/molecules27061756.<\/li>\n<li>V. de la Sovera, G.V. L\u00f3pez,* W. Porcal.* Synthetic Study of 5-Hydroxymethylfurfural in Groebke-Blackburn-Bienaym\u00e9 Reaction. Eur. J. Org. Chem. 2022. https:\/\/doi.org\/10.1002\/ejoc.202101369.<\/li>\n<li>R. Dapueto, J. Rodriguez-Duarte, G. Galliussi, A. Kamaid, M. Bresque, C. Batthy\u00e1ny,* G.V. L\u00f3pez,* C. Escande,* A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity, Redox Biology 2021, 39, 101833. https:\/\/doi.org\/10.1016\/j.redox.2020.101833.<\/li>\n<li>S. Ibarburu, M. Kovacs, V. Varela, J. Rodr\u00edguez-Duarte, M. Ingold, P. Invernizzi, W. Porcal, A.P. Ar\u00e9valo, K. Perelmuter, M. Bollati-Fogol\u00edn, C. Escande, G.V. L\u00f3pez, P. King, Y. Si, Y. Kwon, C. Batthy\u00e1ny, L. Barbeito,* E. Trias.* A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-\u03baB Inhibition. Neurotherapeutics 2020. https:\/\/doi.org\/10.1007\/s13311-020-00953-z.<\/li>\n<li>J. Rodriguez-Duarte, G. Galliussi, R. Dapueto, J. Rossello, L. Malacrida, A. Kamaid, F.J. Schopfer, C. Escande,* Gloria V. L\u00f3pez,* C. Batthy\u00e1ny* A novel nitroalkene-\u03b1-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in apoE knockout mice, Br. J. Pharmacol. 2019, 176(6), 757-772. https:\/\/doi.org\/10.1111\/bph.14561.<\/li>\n<li>M. Ingold, R. Dapueto, S. Victoria, G. Galliussi, C. Batthy\u00e1ny, M. Bollati-Fogol\u00edn, D. Tejedor Arag\u00f3n, F. Garc\u00eda-Tellado, Jos\u00e9 M. Padr\u00f3n, W. Porcal,* Gloria V. L\u00f3pez.* A green multicomponent synthesis of Tocopherol analogues with antiproliferative activities. Eur. J. Med. Chem. 2018, 143, 1888-1902. DOI: 10.1016\/j.ejmech.2017.11.003.<\/li>\n<li>M. Ingold, Gloria V. L\u00f3pez,* W. Porcal.* Green conditions for Passerini three-component synthesis of Tocopherol analogues. ACS Sustain. Chem. Eng. 2014, 2, 1093 &#8211; 1097. https:\/\/doi.org\/10.1021\/sc5002116.<\/li>\n<li>Gloria V. L\u00f3pez; M. Cabrera; Luis E. G\u00f3mez; M. Breijo; C. Pintos; H. Botti; S. Raymondo; A. Vettorazzi; A. L\u00f3pez De Cerain; A. Monge; H. Rubbo; M. Gonz\u00e1lez; H. Cerecetto Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents. Drug Chem. Toxicol. 2011, 34 (3), 285-293. https:\/\/doi.org\/10.3109\/01480545.2010.536769.<\/li>\n<li>Gloria V. L\u00f3pez;* Luis E. G\u00f3mez; N. Campillo; Juan A P\u00e1ez; K. Giles; J. Atkinson; M. Gonz\u00e1lez; H. Rubbo; H. Cerecetto Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity. Bioorg. Med. Chem. 2009, 17, 8143-8148. https:\/\/doi.org\/10.1016\/j.bmc.2009.10.046.<\/li>\n<li>L\u00f3pez G.V., Blanco F., Hern\u00e1ndez P., Ferreira A., Piro O.E., Batthy\u00e1ny C., Gonz\u00e1lez M., Rubbo H., Cerecetto H Second generation of \u03b1-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical and biological characterization Bioorg. Med. Chem. 2007, 15, 6262-6272. https:\/\/doi.org\/10.1016\/j.bmc.2007.06.019.<\/li>\n<li>L\u00f3pez G.V., Batthy\u00e1ny C., Blanco F., Botti H., Trostchansky A., Migliaro E., Radi R., Gonz\u00e1lez M., Cerecetto H. and Rubbo H., Design, Synthesis and Biological Characterization of Novel Antiatherogenic Tocopherol Analogs-Nitric Oxide Donors, Bioorg. Med. Chem. 2005, 13, 5787-5796. https:\/\/doi.org\/10.1016\/j.bmc.2005.05.060.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-areas&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Medicinal Chemistry<\/li>\n<li>Organic Chemistry<\/li>\n<li>Green chemistry<\/li>\n<li>Chronic non-communicable diseases<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Virginia L\u00f3pezVirginia L\u00f3pez, PhD vlopez@pasteur.edu.uy Laboratory of Organic Synthesisand Drug Development PhD in Chemistry, Universidad de la Rep\u00fablica, PEDECIBA-Qu\u00edmica, Uruguay, 2006. Pharmaceutical Chemist, Universidad de la Rep\u00fablica, Uruguay, 2002. Varela, M.; L\u00f3pez, M.; Ingold, M.; Alem, D.; Perini, V.; Perelmuter, K.; Bollati-Fogol\u00edn, M.; L\u00f3pez, G.V.; Hern\u00e1ndez, P. New Nitric Oxide-Releasing Compounds as Promising Anti-Bladder Cancer [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":3590,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"dipi_cpt_category":[],"class_list":["post-24851069","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/24851069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=24851069"}],"version-history":[{"count":2,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/24851069\/revisions"}],"predecessor-version":[{"id":24851072,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/24851069\/revisions\/24851072"}],"up":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/3590"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=24851069"}],"wp:term":[{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=24851069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}