{"id":5202,"date":"2022-04-04T15:52:50","date_gmt":"2022-04-04T15:52:50","guid":{"rendered":"https:\/\/pasteur.uy\/heads-of-labs-and-units\/luis-barbeito\/"},"modified":"2022-08-17T16:14:44","modified_gmt":"2022-08-17T16:14:44","slug":"luis-barbeito","status":"publish","type":"page","link":"https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/luis-barbeito\/","title":{"rendered":"Luis Barbeito"},"content":{"rendered":"

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Luis Barbeito<\/h1>\n

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Luis Barbeito, MD, PhD
<\/span>barbeito@pasteur.edu.uy<\/a><\/p>\n

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Laboratory of
Neurodegeneration<\/p>\n

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\n
    \n
  • \n PhD in Neuropharmacology, Coll\u00e8ge de France, France (1985 \u2013 1989).<\/span>\n <\/li>\n<\/ul><\/div>\n

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      \n
    • Neuroscience<\/li>\n
    • ALS<\/li>\n<\/ul>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.14.6″ _module_preset=”default” max_width=”75%” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” ul_line_height=”1.7em” width=”100%” custom_padding=”|21px||21px|false|true” global_colors_info=”{}”]<\/p>\n

      \n
        \n
      • Est\u00e9vez AG, Crow JP, Sampson JB, Reiter C, Zhuang Y, Richardson GJ, Tarpey MM, Barbeito L, Beckman JS. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science. <\/span>1999<\/strong> <\/span>Dec 24;286(5449):2498-500.<\/li>\n
      • Maccioni RB, Mu\u00f1oz JP, Barbeito L. The molecular bases of Alzheimer\u2019s disease and other neurodegenerative disorders. Arch Med Res. 2001<\/strong> Sep-Oct;32(5):367-81.<\/li>\n
      • Cassina P, Peluffo H, Pehar M, Martinez-Palma L, Ressia A, Beckman JS, Est\u00e9vez AG, Barbeito L. Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J Neurosci Res. 2002<\/strong> Jan 1;67(1):21-9.<\/li>\n
      • Barbeito LH, Pehar M, Cassina P, Vargas MR, Peluffo H, Viera L, Est\u00e9vez AG, Beckman JS. A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res Brain Res Rev. 2004<\/strong> Dec;47(1-3):263-74.<\/li>\n
      • Vargas MR, Pehar M, Cassina P, Beckman JS, Barbeito L. Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis. J Neurochem. 2006<\/strong> May;97(3):687-96.<\/li>\n
      • Pehar M, Vargas MR, Robinson KM, Cassina P, England P, Beckman JS, Alzari PM, Barbeito L. Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons. Free Radic Biol Med. 2006<\/strong> Dec 1;41(11):1632-44.<\/li>\n
      • D\u00edaz-Amarilla P, Olivera-Bravo S, Trias E, Cragnolini A, Mart\u00ednez-Palma L, Cassina P, Beckman J, Barbeito L. Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2011<\/strong>; 108(44):18126-31.<\/li>\n
      • Trias E, D\u00edaz-Amarilla P, Olivera-Bravo S, Isasi E, Drechsel DA, Lopez N, Bradford CS, Ireton KE, Beckman JS, Barbeito L. Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS. Front Cell Neurosci. 2013<\/strong>; 7:274.<\/li>\n
      • Trias, E., et al., Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis. J Neuroinflammation, 2016<\/strong>. 13(1): p. 177.<\/li>\n<\/ul><\/div>\n

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        Luis BarbeitoLuis Barbeito, MD, PhDbarbeito@pasteur.edu.uyLaboratory ofNeurodegeneration PhD in Neuropharmacology, Coll\u00e8ge de France, France (1985 \u2013 1989). Neuroscience ALS Est\u00e9vez AG, Crow JP, Sampson JB, Reiter C, Zhuang Y, Richardson GJ, Tarpey MM, Barbeito L, Beckman JS. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science. 1999 Dec 24;286(5449):2498-500. Maccioni RB, Mu\u00f1oz […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":3590,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"dipi_cpt_category":[],"class_list":["post-5202","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=5202"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5202\/revisions"}],"predecessor-version":[{"id":7503,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5202\/revisions\/7503"}],"up":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/3590"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=5202"}],"wp:term":[{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=5202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}