{"id":5226,"date":"2022-04-04T17:07:14","date_gmt":"2022-04-04T17:07:14","guid":{"rendered":"https:\/\/pasteur.uy\/heads-of-labs-and-units\/hugo-peluffo\/"},"modified":"2022-08-17T16:12:17","modified_gmt":"2022-08-17T16:12:17","slug":"hugo-peluffo","status":"publish","type":"page","link":"https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/hugo-peluffo\/","title":{"rendered":"Hugo Peluffo"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; 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header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#005293&#8243; header_font_size=&#8221;39px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Hugo Peluffo<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p class=\"et_pb_member_position et-fb-editable-element et-fb-editable-element__editing\" data-shortcode-id=\"0.0.0.0-1643373697362\" data-quickaccess-id=\"position\" contenteditable=\"true\">Hugo Peluffo, PhD<\/p>\n<div data-shortcode-id=\"0.0.0.0-1643374141066\" data-quickaccess-id=\"body\" data-quickaccess-editable=\"yes\" class=\"et-fb-popover-tinymce\">\n<div class=\"mce-content-body\" contenteditable=\"true\" style=\"position: relative;\">\n<p>\n                <a href=\"mailto:hugo.peluffo@pasteur.edu.uy\">hugo.peluffo@pasteur.edu.uy<\/a>\n              <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#ce8e00&#8243; 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custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Neuroinflammation and Gene Therapy Laboratory<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;500ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; module_class=&#8221;df-buttons &#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_margin_tablet=&#8221;||0px||false|false&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;18px||0px||false|false&#8221; 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button_bg_color=&#8221;rgba(0,82,147,0.16)&#8221; button_border_width=&#8221;0px&#8221; button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_text=&#8221;Relevant publications&#8221; button_alignment=&#8221;center&#8221; module_class=&#8221;dfc-publicaciones df-button&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#005293&#8243; button_bg_color=&#8221;rgba(0,82,147,0.16)&#8221; button_border_width=&#8221;0px&#8221; button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;df-rows df-area dfc-educacion&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;15px||||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;600ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row module_class=&#8221;dfc-educacion&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>BSc in Biological Science, Faculty of Science, University of the Republic, Uruguay (1992-1998).<\/li>\n<li>MSc in Biological Science, Faculty of Medicine, University of the Republic, Uruguay (2000).<\/li>\n<li>MSc in Neuroscience, Universidad Aut\u00f3noma de Barcelona, Spain (2003).<\/li>\n<li>PhD in Neurosciencie (<a href=\"http:\/\/www.tesisenxarxa.net\/TDX-1123106-092303\/\">link to thesis<\/a>), Universidad Aut\u00f3noma de Barcelona, Spain (2001-2006).<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-areas&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Neuroinflamation<\/li>\n<li>Microglia<\/li>\n<li>Gene Therapy<\/li>\n<li>Neurotrauma<\/li>\n<li>Immunoreceptors<\/li>\n<li>Major depression<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-publicaciones&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; 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H. Peluffo, A. G. Est\u00e9vez, L. Barbeito y J. M. Stutzman. Riluzole promotes survival of rat motorneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers. Neuroscience Letters 228:207-211 (1997).<\/li>\n<li>2. P. Cassina*, H. Peluffo*, M. Pehar, L. Mart\u00ednez-Palma, A. Ressia, J. S. Beckman, A. Est\u00e9vez y L. Barbeito. Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J. Neurosci. Res. 67:21-29 (2001). *Ambos autores contribuyeron igualmente a este trabajo.<\/li>\n<li>3. Peluffo, H. * Ar\u00eds, A. Acarin, L. Gonz\u00e1lez, B. Villaverde, A. and Castellano, B. Non-viral gene delivery to the CNS based on a novel integrin targeting multifunctional protein. Human Gene Therapy 14:12-15 (2003). * Autor al que debe dirigirse la correspondencia.<\/li>\n<li>4. H. Peluffo*, P. Gonz\u00e1lez, A. Ar\u00eds, L. Acarin*, A. Villaverde, B. Castellano, B. Gonz\u00e1lez. RGD domains neuroprotect the immature brain by a glial dependent mechanism. Annals of Neurology. 62:251-261 (2007). *Autores a los que debe dirigirse la correspondencia.<\/li>\n<li>5. Domingo-Esp\u00edn, J., E. Vazquez, J. Ganz, O. Conchillo, E. Garc\u00eda-Fruit\u00f3s, J. Cedano, U. Unzueta, V. Petegnief, N. Gonzalez-Montalb\u00e1n, A.M. Planas, X. Daura, H. Peluffo, N. Ferrer-Miralles, y A. Villaverde. The nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions. Nanomedicine. 6:1047-1061 (2011).<\/li>\n<li>6. Peluffo, H*; Al\u00ed-Ruiz, D; Ejarque-Ort\u00edz, A; Heras-Alvarez, V; Comas-Casellas, E; Mart\u00ednez-Barriocanal, A; Kamaid, A; Alvarez-Errico, D; Negro, ML; Lago, N; Schwartz S Jr; Villaverde, A; y Say\u00f3s, J. Overexpression of the immunoreceptor CD300f has a neuroprotective role in a model of acute brain injury. Brain Pathology (Epub 2011) 22:318-328 (2012). * Autor al que debe dirigirse la correspondencia.<\/li>\n<li>7. *Peluffo, H., *Foster, E., Ahmed, S.G., Lago, N., Hutson, T.H., Moon, L., Yip, P., Wanisch, K., Caraballo-Miralles, V., Olmos, G., Llad\u00f3, J., McMahon, S.B. and Y\u00e1\u00f1ez-Mu\u00f1oz, R.J. Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord. Gene Therapy 20:645-657, 2013. *Ambos autores contribuyeron igualmente al trabajo.<\/li>\n<li>8. Negro, M.L. P. Saccardo, C. Giacomini, R.J. Y\u00e1\u00f1ez-Mu\u00f1oz, N. Ferrer-Miralles, E. Vazquez, A. Villaverde and H, Peluffo*. Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Molecular Therapy \u2013 Methods &amp; Clinical Development, 1:14047, 2014. *Autor al que debe dirigirse la correspondencia.<\/li>\n<li>9. Peluffo H*, Solari-Saquieres P*, Negro-Demontel ML, Francos-Quijorna I, Navarro X, L\u00f3pez-Vales R, Say\u00f3s J, Lago N. CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype. J. Neuroinflammation, 12:145 (12 August) 2015. *Ambos autores contribuyeron igualmente al trabajo.<\/li>\n<li>10. Hugo Peluffo, Ugutz Unzueta, Mar\u00eda Luciana Negro, Zhikun Xu, Esther Vazquez, Neus Ferrer-Miralles and Antonio Villaverde. BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS. Biotechnology Advances, 33(2):277-287, 2015<\/li>\n<li>11. Fernanda N. Kaufmann, Ana Paula Costa, Gabriele Ghisleni, Alexandre P. Diaz, Ana L\u00facia Rodrigues, Hugo Peluffo, Manuella Pinto Kaster. NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings. Brain Behavior and Immunity, 64: 367-383, 2017.<\/li>\n<li>12. Natalia Lago, Bruno Pannunzio, Jes\u00fas Amo-Aparicio, Rub\u00e8n L\u00f3pez-Vales and Hugo Peluffo. CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1. Brain Behaviour and Immunity Junio, 2018.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hugo PeluffoHugo Peluffo, PhD hugo.peluffo@pasteur.edu.uy Neuroinflammation and Gene Therapy Laboratory BSc in Biological Science, Faculty of Science, University of the Republic, Uruguay (1992-1998). MSc in Biological Science, Faculty of Medicine, University of the Republic, Uruguay (2000). MSc in Neuroscience, Universidad Aut\u00f3noma de Barcelona, Spain (2003). PhD in Neurosciencie (link to thesis), Universidad Aut\u00f3noma de Barcelona, [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":3590,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"dipi_cpt_category":[],"class_list":["post-5226","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=5226"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5226\/revisions"}],"predecessor-version":[{"id":7495,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5226\/revisions\/7495"}],"up":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/3590"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=5226"}],"wp:term":[{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=5226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}