{"id":5256,"date":"2022-04-04T17:34:19","date_gmt":"2022-04-04T17:34:19","guid":{"rendered":"https:\/\/pasteur.uy\/heads-of-labs-and-units\/eduardo-osinaga\/"},"modified":"2023-03-03T14:47:25","modified_gmt":"2023-03-03T14:47:25","slug":"eduardo-osinaga","status":"publish","type":"page","link":"https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/eduardo-osinaga\/","title":{"rendered":"Eduardo Osinaga"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; 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header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#005293&#8243; header_font_size=&#8221;39px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Eduardo Osinaga<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"et_pb_member_position et-fb-editable-element et-fb-editable-element__editing\" data-shortcode-id=\"0.0.0.0-1643373697362\" data-quickaccess-id=\"position\" contenteditable=\"true\">Eduardo Osinaga, MD, PhD<\/p>\n<div data-shortcode-id=\"0.0.0.0-1643374141066\" data-quickaccess-id=\"body\" data-quickaccess-editable=\"yes\" class=\"et-fb-popover-tinymce\">\n<div class=\"mce-content-body\" contenteditable=\"true\" style=\"position: relative;\">\n<p>\n                <a href=\"mailto:eosinaga@pasteur.edu.uy\">eosinaga@pasteur.edu.uy<\/a>\n              <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#ce8e00&#8243; 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custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Glycobiology and Tumor Immunology Laboratory<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;500ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; module_class=&#8221;df-buttons &#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_margin_tablet=&#8221;||0px||false|false&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;18px||0px||false|false&#8221; 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_builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#005293&#8243; button_bg_color=&#8221;rgba(0,82,147,0.16)&#8221; button_border_width=&#8221;0px&#8221; button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;df-rows df-area dfc-educacion&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;15px||||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;600ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row module_class=&#8221;dfc-educacion&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>PhD in Biological Science. Thesis: \u201cEtude de glycoprot\u00e9ines associ\u00e9es aux carcinomes a l\u2019aide d\u2019anticorps monoclonaux. Caract\u00e9risation mol\u00e9culaire, structure de l\u2019epitope et interet diagnostique de l\u2019antig\u00e8ne 83D4\u201d, Universidad de Tecnolog\u00eda de Compi\u00e8gne, France (1992).<\/li>\n<li>MSc in Biotechnology. Enzymatic engineering, bioconversion and microbiology, Universidad de Tecnolog\u00eda de Compi\u00e8gne, France (1989).<\/li>\n<li>Medical Doctor (MD), Faculty of Medicine, Udelar, Uruguay (1984).<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-areas&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Immunology<\/li>\n<li>Glicobiology<\/li>\n<li>Oncology<\/li>\n<li>Biotechnology<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-publicaciones&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; ul_line_height=&#8221;1.7em&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<ul>\n<li>Berois N, Pittini A, Osinaga E. Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives. Cancers.; 14:645. https:\/\/doi.org\/10.3390\/cancers14030645 (2022)<\/li>\n<li>Freire T, Landeira M, Giacomini C, Festari MF, Pittini \u00c1, Cardozo V, Brosque A, Monin L, da Costa V, Faral-Tello P, Robello C, Osinaga E. Trypanosoma cruzi-Derived Molecules Induce Anti-Tumour Protection by Favouring Both Innate and Adaptive Immune Responses. Int J Mol Sci. 23:15032 (2022)<\/li>\n<li>Castro A, Berois N, Malanga A, Ortega C, Oppezzo P, Pristch P, Mombr\u00fa AW, Osinaga E, Pardo H. Docetaxel in chitosan-based nanocapsules conjugated with an anti-Tn antigen mouse\/human chimeric antibody as a promising targeting strategy of lung tumors. International Journal of Biological Macromolecules 182:806-814 (2021)<\/li>\n<li>Berriel E, Freire T, Chiale C, Rodr\u00edguez E, Mor\u00f3n G, Fern\u00e1ndez-Gra\u00f1a G, Crispo M, Berois N, Osinaga E. Human hydatid cyst fluid induced therapeutic anti-cancer immune responses via NK1.1 cell activation in mice. Cancer Immunology Immunotherapy 70:3617-3627 (2021)<\/li>\n<li>da Costa V, van Vliet SJ, Carasi P, Frigerio S, Garc\u00eda PA, Croci DO, Festari MF, Costa M, Landeira M, Rodr\u00edguez-Zraquia SA, Cagnoni AJ, Cutine AM, Rabinovich GA, Osinaga E, Mari\u00f1o KV, Freire T. The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2). Cancer Lett. 518:72-81 (2021)<\/li>\n<li>Fernandez E, Ubillos L, Elgul N, Festari MF, Mazal D, Pritsch O, Alonso I, Osinaga E, Berois N. Polypeptide-GalNAc-Transferase-13 Shows Prognostic Impact in Breast Cancer. Cancers (Basel). 13:5616. (2021)<\/li>\n<li>Festari MF, Trajtenberg F, Berois N, Pantano S, Revoredo L, Kong Y, Solari-Saquieres P, Narimatsu Y, Freire T, Bay S, Robello C, B\u00e9nard J, Gerken TA, Clausen H, Osinaga E. Revisiting the human polypeptide GalNAc-T1 and T13 paralogs. Glycobiology 27:140-153 (2017)<\/li>\n<li>Ubillos L, Freire T, Berriel E, Chiribao ML, Chiale C, Festari MF, Medeiros A, Mazal D, Rond\u00e1n M, Bollati-Fogol\u00edn M, Rabinovich GA, Robello C and Osinaga E. Trypanosoma cruzi extracts elicits protective immune response against chemically-induced colon and mammary cancers. <br \/>Int J Cancer 138:1719-31 (2016)<\/li>\n<li>Garc\u00eda E, Tiscornia I, Libisch G, Trajtenberg F, Bollati-Fogol\u00edn M, Rodr\u00edguez E, Noya V, Chiale C, Brossard N, Robello C, Santi\u00f1aque F, Folle G, Osinaga E and Freire T. MUC5B silencing reduces chemo-resistance of MCF-7 breast tumor cells and impairs maturation of dendritic cells. Int. J. Oncol. 48:2113-23 (2016)<\/li>\n<li>Sedlik C, Heitzmann A, Viel S, Ait Sarkouh R, Batisse C, Schmidt F, De La Rochere P, Amzallag N, Osinaga E, Oppezzo P, Pritsch O, Sastre-Garau X, Hubert P, Amigorena S, Piaggio E. Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen. Oncoimmunology. 5:e1171434 (2016)<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eduardo OsinagaEduardo Osinaga, MD, PhD eosinaga@pasteur.edu.uy Glycobiology and Tumor Immunology Laboratory PhD in Biological Science. Thesis: \u201cEtude de glycoprot\u00e9ines associ\u00e9es aux carcinomes a l\u2019aide d\u2019anticorps monoclonaux. Caract\u00e9risation mol\u00e9culaire, structure de l\u2019epitope et interet diagnostique de l\u2019antig\u00e8ne 83D4\u201d, Universidad de Tecnolog\u00eda de Compi\u00e8gne, France (1992). MSc in Biotechnology. Enzymatic engineering, bioconversion and microbiology, Universidad de Tecnolog\u00eda [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":3590,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"dipi_cpt_category":[],"class_list":["post-5256","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=5256"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5256\/revisions"}],"predecessor-version":[{"id":8920,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5256\/revisions\/8920"}],"up":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/3590"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=5256"}],"wp:term":[{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=5256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}