{"id":5275,"date":"2022-04-04T17:57:48","date_gmt":"2022-04-04T17:57:48","guid":{"rendered":"https:\/\/pasteur.uy\/heads-of-labs-and-units\/alejandro-buschiazzo\/"},"modified":"2022-08-17T16:06:06","modified_gmt":"2022-08-17T16:06:06","slug":"alejandro-buschiazzo","status":"publish","type":"page","link":"https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/alejandro-buschiazzo\/","title":{"rendered":"Alejandro Buschiazzo"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; custom_margin_phone=&#8221;||||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;||10px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;300ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.14.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Buschiazzo-Alejandro.jpg&#8221; title_text=&#8221;Buschiazzo, Alejandro&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.14.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;|700|||||||&#8221; text_font_size=&#8221;21px&#8221; header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#005293&#8243; header_font_size=&#8221;39px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Alejandro Buschiazzo<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p class=\"et_pb_member_position et-fb-editable-element et-fb-editable-element__editing\" data-shortcode-id=\"0.0.0.0-1643373697362\" data-quickaccess-id=\"position\" contenteditable=\"true\">Alejandro Buschiazzo, PhD<\/p>\n<div data-shortcode-id=\"0.0.0.0-1643374141066\" data-quickaccess-id=\"body\" data-quickaccess-editable=\"yes\" class=\"et-fb-popover-tinymce\">\n<div class=\"mce-content-body\" contenteditable=\"true\" style=\"position: relative;\">\n<p>\n                <a href=\"mailto:alebus@pasteur.edu.uy\">alebus@pasteur.edu.uy<\/a>\n              <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#ce8e00&#8243; 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custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Molecular and Structural Microbiology Laboratory<\/p>\n<p>Protein Crystallography Unit<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;500ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; module_class=&#8221;df-buttons &#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_margin_tablet=&#8221;||0px||false|false&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; 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module_class=&#8221;dfc-publicaciones df-button&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#005293&#8243; button_bg_color=&#8221;rgba(0,82,147,0.16)&#8221; button_border_width=&#8221;0px&#8221; button_border_color=&#8221;#005293&#8243; button_border_radius=&#8221;0px&#8221; button_font=&#8221;|700|||||||&#8221; button_use_icon=&#8221;off&#8221; transform_scale=&#8221;97%|97%&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; custom_css_main_element=&#8221;width: 100% !important;&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover_enabled=&#8221;on|desktop&#8221; button_text_color__hover=&#8221;#FFFFFF&#8221; button_bg_color__hover_enabled=&#8221;on|hover&#8221; button_bg_color__hover=&#8221;#005293&#8243; button_bg_enable_color__hover=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;df-rows df-area dfc-educacion&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;15px||||false|false&#8221; animation_style=&#8221;fade&#8221; animation_duration=&#8221;600ms&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row module_class=&#8221;dfc-educacion&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>BSC in Biological Science, Faculty of Natural Science, Universidad Nacional de La Plata, Argentina (1991).<\/li>\n<li>PhD in Chemical Science, Leloir Institute, Universidad de Buenos Aires, Argentina (1999).<\/li>\n<li>Posdoc in Structural Biology of Trypanosomatid Sialidases, Institut Pasteur, France (1999-2003).<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-areas&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Protein biochemistry<\/li>\n<li>Structural Biology<\/li>\n<li>Phosphorylation and protein alosterism<\/li>\n<li>Molecular microbiology<\/li>\n<li>Signaling and regulation in bacteria<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=&#8221;dfc-publicaciones&#8221; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;75%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.6&#8243; _module_preset=&#8221;default&#8221; ul_line_height=&#8221;1.7em&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;|21px||21px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Adhikarla H, Wunder EA Jr, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI. (2018) Lvr, a signaling system that controls global gene regulation and virulence in pathogenic Leptospira. Front Cell Infect Microbiol 8:45.<\/li>\n<li>Wunder EA, Figueira CP, Benaroudj N, Hu B, Tong BA, Trajtenberg F, Liu J, Reis MG, Charon NW, Buschiazzo A, Picardeau M &amp; Ko AI. (2016) A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete. Mol Microbiol. 101:457-70.<\/li>\n<li>Trajtenberg F, Imelio JA, Machado MR, Larrieux N, Marti MA, Obal G, Mechaly AE, Buschiazzo A. (2016) Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action. eLife 5:e21422.<\/li>\n<li>Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, et al. (2016) What makes a bacterial species pathogenic?: comparative genomic analysis of the genus Leptospira. PLoS Negl Trop Dis. 10:e0004403.<\/li>\n<li>Obal G, Trajtenberg F, Carri\u00f3n F, Tom\u00e9 L, Larrieux N, Zhang X, Pritsch O, Buschiazzo A. (2015) Conformational plasticity of a native retroviral capsid revealed by X-ray crystallography. Science 349:95-8.<\/li>\n<li>Methot SP, Litzler LC, Trajtenberg F, Zahn A, Robert F, Pelletier J, Buschiazzo A, Magor BG, Di Noia JM. (2015) Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J Exp Med. 212:581-96.<\/li>\n<li>Trajtenberg F, Albanesi D, Ru\u00e9talo N, Botti H, Mechaly AE, Nieves M, Aguilar PS, Cybulski L, Larrieux N, de Mendoza D, Buschiazzo A. (2014) Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation. mBio. 5:e02105.<\/li>\n<li>Morero NR, Botti H, Nitta KR, Carri\u00f3n F, Obal G, Picardeau M, Buschiazzo A. (2014) HemR is an OmpR\/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes. Mol Microbiol. 94:340-52.<\/li>\n<li>Trajtenberg F, Gra\u00f1a M, Ru\u00e9talo N, Botti H, Buschiazzo A. (2010) Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase. J Biol Chem. 285:24892-903.<\/li>\n<li>Albanesi D, Mart\u00edn M, Trajtenberg F, Mansilla MC, Haouz A, Alzari PM, de Mendoza D &amp; Buschiazzo A. (2009) Structural plasticity and catalysis regulation of a thermosensor histidine kinase. Proc Natl Acad Sci USA. 106:16185-90.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alejandro BuschiazzoAlejandro Buschiazzo, PhD alebus@pasteur.edu.uy Molecular and Structural Microbiology Laboratory Protein Crystallography Unit BSC in Biological Science, Faculty of Natural Science, Universidad Nacional de La Plata, Argentina (1991). PhD in Chemical Science, Leloir Institute, Universidad de Buenos Aires, Argentina (1999). Posdoc in Structural Biology of Trypanosomatid Sialidases, Institut Pasteur, France (1999-2003). Protein biochemistry Structural Biology [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":3590,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"dipi_cpt_category":[],"class_list":["post-5275","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=5275"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5275\/revisions"}],"predecessor-version":[{"id":7477,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/5275\/revisions\/7477"}],"up":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/pages\/3590"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=5275"}],"wp:term":[{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=5275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}