{"id":4467,"date":"2022-03-11T15:06:53","date_gmt":"2022-03-11T15:06:53","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/protemca\/"},"modified":"2026-05-11T16:47:05","modified_gmt":"2026-05-11T19:47:05","slug":"protemca","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/programmes\/protemca\/","title":{"rendered":"ProTeMCA"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”9px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_margin=”|auto|0px|auto|false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Titillium Web|700|||||||” header_font=”Titillium Web|700|||||||” header_text_color=”#005293″ header_font_size=”44px” custom_margin=”||22px|||” header_font_size_tablet=”38px” header_font_size_phone=”29px” header_font_size_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

ProTeMCA<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

The Molecular, Cellular and Animal Technology Program (ProTeMCA) has as mission to integrate the knowledge and technological capabilities of different groups of the Institut Pasteur of Montevideo to promote the development of research and innovative technology in the area of genetic engineering, bioassays and models based in proteins, cells or animals.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Stressing the link of scientific knowledge with its application, through dynamic interaction with academia and industry, the program seeks to contribute to solve problems in biotechnology using new tools, products, processes or services. It also collaborates with research groups or private institutions to develop molecular technologies that help the improvement of (bio) drugs, cells or animals.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”-31px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Within the IP Montevideo, the program involves the joint work of the Redox Biology of Trypanosomatids Laboratory<\/a>, theBiomolecular Simulations Laboratory<\/a>, the Biotechnology in Laboratory Animals Unit<\/a> and the Cell Biology Unit<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px|0px|false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_5,1_5,1_5,1_5,1_5″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Members” button_alignment=”center” module_class=”df-button dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Research lines” button_alignment=”center” module_class=”df-button dfc-investigacion” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;||letter-spacing: -0.5px;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Courses” button_alignment=”center” module_class=”df-button dfc-cursos” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Projects” button_alignment=”center” module_class=”df-button dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” 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global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Cecilia Abreu, PhD” position=”Associate researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/02\/Abreu-Cecilia-nueva.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

\n cabreu@pasteur.edu.uy<\/a>\n <\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Claudia Ortega, PhD” position=”Senior associate technician” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Ortega-Claudia.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

\n ckortega@pasteur.edu.uy<\/a>\n <\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Luc\u00eda Bassetti, BSc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Bassetti-Lucia.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

\n lbassetti@pasteur.edu.uy<\/a>\n <\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Florencia Fadel, BSc” position=”Master's degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Fadel-Florencia-ajustada.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

ffadel@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Gabriela Paradeda, BSc” position=”Master's degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Paradeda-Gabriela.jpg” _builder_version=”4.27.3″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

\n gparadeda@pasteur.edu.uy<\/a>\n <\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Agustina Ben\u00cdtez” position=”Pasante” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Benitez-Agustina-ajustada.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

abenitez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”\u00c1ngela Tesitore” position=”Pasante” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Tesitore-Angela-ajustada.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

atesitore@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”26px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

FOUNDING MEMBERS<\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Mariela Bollati, PhD” position=”Cell Biology Unit” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Bollati-Mariela.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/mariela-bollati\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Marcelo Comini, PhD” position=”Redox Biology of Trypanosomatids Laboratory” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Comini-Marcelo.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/marcelo-comini\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”DVM Martina Crispo, PhD” position=”Biotechnology in Laboratory Animals Unit” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Crispo-Martina-1.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/martina-crispo\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Sergio Pantano, PhD” position=”Biomolecular Simulations Laboratory” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Pantano-Sergio.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/sergio-pantano\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”][\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Design and refinement of products<\/strong> of biotechnological interest.<\/p>\n

<\/p>\n

Development of new high performance cellular assays<\/strong>.<\/p>\n

<\/p>\n

Cell or animal models<\/strong> for toxicological studies and diseases.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-cursos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Courses<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    \n
  • “XTREME- Bruker in vivo imaging technology”. February 2017, Montevideo.<\/li>\n
  • “ICGEB Course: Cell and animal models for drug discovery”. October 2017, Montevideo.<\/li>\n
  • “Alternatives methods to animal research”. May 2018, Montevideo.<\/li>\n
  • “Workshop and Training Course on Molecular, Physical and Computational Virology”. October-November 2024, Montevideo.<\/li>\n
  • “Applications and Good Practices in the Use of Cell Cultures”. 2025-2026, Montevideo.<\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Projects<\/h2>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2026-…<\/strong> \u2013 Thermostable Viral Particle\u2013Mediated RNA Delivery. Inspire, Institut Pasteur de Montevideo. Principal Investigator: Claudia Ortega.<\/p>\n

    <\/p>\n

    2025-2026<\/strong> \u2013 PDIA1 and PDIA3 disulfide isomerase proteins: a study of their role in the entry of the bovine leukemia virus into cells. – Proyecto Transversal, Institut Pasteur de Montevideo. Principal Investigators: Cecilia Abreu, Natalia Olivero-Deibe, Azalia Rodr\u00edguez.<\/p>\n

    <\/p>\n

    2024-2026<\/strong> \u2013 Mammalian Cell Platform for Porcine Circovirus 2 : A new adaptable vaccine prototype. Mar\u00eda Vi\u00f1as Fund. National Agency for Research and Innovation (ANII). Principal Investigator: Claudia Ortega, Co-Investigator: Sergio Pantano.<\/p>\n

    <\/p>\n

     <\/p>\n

    <\/p>\n

     <\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”3px|||||” custom_padding=”0px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2019-2021<\/strong> \u2013 Generation of extracts rich in polyphenols from grape pomace. Alliance for Innovation- Technological Development Modality. ANII ALI_2_2018_1_149574. Collaborators: Mariela Bollati and Marcelo Comini.<\/p>\n

    <\/p>\n

    2019- 2021 <\/strong>\u2013 New molecular tools for the reduction of production costs of bioactive molecules (FMV_3_2018 _l_148443, ANII). Head: Cecilia Abreu<\/p>\n

    <\/p>\n

    2016-2019<\/strong> \u2013 Design and production of new variants of the follicle stimulating hormone (FSH) for its use in species of productive interest \u2013 National Agency for Research and Innovation, ANII (ALI_1_2015_1_5084). Principal Investigator: Mariela Bollati-Fogolin.<\/p>\n

    <\/p>\n

    2015-2018<\/strong> \u2013 Design of biosensors for simultaneous monitoring of redox signaling and cAMP: from the computer to the cell and back to the computer \u2013 National Agency for Research and Innovation, Project FMV_1_2014_1_104000. Main investigator: Sergio Pantano.<\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||26px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Main publications<\/h2>\n

    [\/et_pb_text][et_pb_accordion icon_color=”#005293″ _builder_version=”4.27.6″ _module_preset=”default” toggle_text_color=”#005293″ toggle_font=”Titillium Web|600|||||||” toggle_font_size=”17px” custom_margin=”||||false|false” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″][et_pb_accordion_item title=”vacio” open=”on” _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display:none” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_accordion_item][et_pb_accordion_item title=”2026″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

      \n
    • Bassetti L, Crispo M, Bollati-Fogol\u00edn M, Pantano S, Comini MA, Abreu C. Exploring elastin-like polypeptide tags and mini-intein for recombinant protein purification in Leishmania tarentolae. Protein Expr Purif. 2026 Feb 19:241:106902. doi: 10.1016\/j.pep.2026.106902.<\/li>\n
    • Fadel F, Paradeda G and Ortega C. Production and Characterization of Porcine Circovirus Type 2 (PCV2) Virus-Like Particles: Methodological Approaches and Biotechnological Application. Virus-Like Particles: Methods and Protocols. Methods in Molecular Biology, Springer Nature. 2026 In press.<\/li>\n<\/ul>\n

      [\/et_pb_accordion_item][et_pb_accordion_item title=”2025″ _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” open=”off” sticky_enabled=”0″]<\/p>\n

        \n
      • Cancela S, Sena F, Pagotto R, Crispo M, Francia ME, Bollati-Fogol\u00edn M. Enhancing pre-sexual and sexual differentiation of Toxoplasma gondii using retinal epithelial cells and intestinal organoids. Cell Rep. 2025 Oct 28;44(10):116451. doi: 10.1016\/j.celrep.2025.116451. Epub 2025 Oct 17.<\/li>\n
      • Piattoni CV, Abreu C, Machado MR, Pantano S, Comini MA, Bollati-Fogol\u00edn M. . A red-shifted biosensor for intracellular detection of cAMP: the CUTieR the better. Biochem Biophys Res Commun. 2025 ;766:151831. doi: 10.1016\/j.bbrc.2025.151831.<\/li>\n
      • Olivero-Deibe N, Frigini EN, Ramos N, Carri\u00f3n F, Fadel F, Villarreal L, Benech JC, Arbiza J, Pantano S, Ortega C.. The stability of PCV2 virus-like particles from mammalian cells and challenges for biotechnological applications. Vaccine. 2025 Jan 12;44:126549. doi: 10.1016\/j.vaccine.2024.126549.<\/li>\n<\/ul>\n

        [\/et_pb_accordion_item][et_pb_accordion_item title=”2024″ _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” open=”off” sticky_enabled=”0″]<\/p>\n

          \n
        • Abreu C, Grunberg K, Bonilla M, Crispo M, Pantano S, Jaeschke J, Comini MA, Bollati-Fogol\u00edn M.. Expression and functional characterization of chimeric recombinant bovine follicle-stimulating hormone produced in Leishmania tarentolae. Microb Biotechnol. 2024 Apr;17(4):e14444. doi: 10.1111\/1751-7915.14444.<\/li>\n<\/ul>\n

          [\/et_pb_accordion_item][et_pb_accordion_item title=”2023″ _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” open=”off” sticky_enabled=”0″]<\/p>\n

            \n
          • Gonzalez AC, Abreu C, Pantano S, Comini M, Malacrida L, Egger B, Cantera R, Prieto D. A FRET-based cGMP biosensor in Drosophila. MicroPubl Biol . 2023 Nov 28:2023:10.17912\/micropub.biology.000887. doi: 10.17912\/micropub.biology.000887. eCollection 2023.<\/li>\n
          • Abreu C, Ortega C, Olivero-Deibe N, Carri\u00f3n F, Gaete-Argel A, Valiente-Echeverr\u00eda F, Soto-Rifo R, Milan Bonotto R, Marcello A, Pantano S.. Customizably designed multibodies neutralize SARS-CoV-2 in a variant-insensitive manner. Front Immunol. 2023 Aug 10:14:1226880. doi: 10.3389\/fimmu.2023.1226880. eCollection 2023.<\/li>\n<\/ul>\n

            [\/et_pb_accordion_item][et_pb_accordion_item title=”2022″ _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” open=”off” sticky_enabled=”0″]<\/p>\n

              \n
            • Klein F, Abreu C, Pantano S. How to Make the CUTiest Sensor in Three Simple Steps for Computational Pedestrians. Methods Mol Biol. 2022:2483:255-264. doi: 10.1007\/978-1-0716-2245-2_16<\/li>\n
            • Perelmuter, K., Tiscornia, I., Comini, M. A., & Bollati-Fogol\u00edn, M. (2022). Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance. Sensors (Basel, Switzerland), 22(4), 1324. https:\/\/doi.org\/10.3390\/s22041324<\/li>\n<\/ul>\n

              [\/et_pb_accordion_item][et_pb_accordion_item title=”2021″ _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” open=”off” sticky_enabled=”0″]<\/p>\n

                \n
              • Ar\u00e9valo A.P., Pagotto R., P\u00f3rfido J. L., Daghero H., Segovia M., Yamasaki K., Varela, Hill M., Verdes J. M., Duhalde Vega M., Bollati-Fogol\u00edn M. & Crispo M. (2021). Ivermectin reduces in vivo coronavirus infection in a mouse experimental model. Sci Rep 11, 7132. https:\/\/doi.org\/10.1038\/s41598-021-86679-0<\/li>\n
              • Klein F, Sardi F, Machado MR, Ortega C, Comini MA, Pantano S. CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones. Front Mol Biosci. 2021 Mar 11;8:629773. doi: 10.3389\/fmolb.2021.629773. PMID: 33778003; PMCID: PMC7991088.<\/li>\n<\/ul>\n

                [\/et_pb_accordion_item][et_pb_accordion_item title=”2020″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                  \n
                • Parakh S, Shadfar S, Perri ER, Ragagnin AMG, Piattoni CV, Fogol\u00edn MB, Yuan KC, Shahheydari H, Don EK, Thomas CJ, Hong Y, Comini MA, Laird AS, Spencer DM, Atkin JD. (2020). The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models. iScience; 23(5):101097. doi: 10.1016\/j.isci.2020.101097.<\/li>\n
                • Medeiros A, Ben\u00edtez D, Korn RS, Ferreira VC, Barrera E, Carri\u00f3n F, Pritsch O, Pantano S, Kunick C, de Oliveira CI, Orban OCF, Comini MA. Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1345-1358. doi: 10.1080\/14756366.2020.1780227. PMID: 32588679; PMCID: PMC7717452<\/li>\n<\/ul>\n

                  [\/et_pb_accordion_item][et_pb_accordion_item title=”2019″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                    \n
                  • Piattoni CV, Sardi F, Klein F, Pantano S, Bollati-Fogolin M, Comini M. New red-shifted fluorescent biosensor for monitoring intracellular redox changes. Free Radic Biol Med. 2019 Feb 5;134:545-554<\/li>\n<\/ul>\n

                    [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

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