{"id":4470,"date":"2022-03-11T15:22:20","date_gmt":"2022-03-11T15:22:20","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/indicyo\/"},"modified":"2022-04-04T19:07:12","modified_gmt":"2022-04-04T19:07:12","slug":"indicyo","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/programmes\/human-health\/indicyo\/","title":{"rendered":"INDICyO"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”9px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” custom_margin=”|auto|0px|auto|false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” text_font=”Titillium Web|700|||||||” header_font=”Titillium Web|700|||||||” header_text_color=”#005293″ header_font_size=”44px” custom_margin=”||22px|||” header_font_size_tablet=”38px” header_font_size_phone=”29px” header_font_size_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

INDICyO<\/span><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Created in 2016, the Research in Diabetes, Inflammation, Cardiovascular Diseases and Obesity program (INDICyO) is a multidisciplinary initiative that brings together four laboratories of the institute to collaborate in the study of these chronic diseases.<\/p>\n

These pathologies of metabolism \u2014defined by the World Health Organization (WHO) as the XXI century epidemic\u2014 are associated with aging, poor eating habits and sedentary lifestyle. Its incidence has increased alarmingly in the last 60 years and is currently the leading cause of death in Uruguay and worldwide. Although these diseases are preventable \u2014especially through the promotion of better life habits\u2014 it is important to develop new strategies that allow improving their prognosis.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

At a biological level, since these diseases are characterized by a chronic inflammatory response in their molecular bases (like arterial hypertension and atherosclerosis, among others), it is key to understand the mechanism that could lead to the development of alternative therapies, whether at the pharmacological or genetic. It is also important to collaborate in the design of public health strategies that improve the incidence and prognosis of these diseases in Uruguay.<\/p>\n

The program aims to place the Institut Pasteur de Montevideo as themain biomedical research center for these diseases in Uruguay, bringing together in-house researchers and experts from other national and international academic institutions that also work on these issues. In addition, within the International Network of Pasteur Institutes (RIIP), IP Montevideo also seeks to strengthen its position to become a reference in this area.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”0px||0px|0px|false|false” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_5,1_5,1_5,1_5,1_5″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.14.6″ _module_preset=”default” width=”100%” max_width=”80%” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_5″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Members” button_alignment=”center” module_class=”df-button dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px|6px|10px|6px|false|true” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Projects” button_alignment=”center” module_class=”df-button dfc-investigacion” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px|6px|10px|6px|false|true” custom_css_main_element=”width: 100% !important;||letter-spacing: -0.5px;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Main equipment” button_alignment=”center” module_class=”df-button dfc-equipos” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px|6px|10px|6px|false|true” custom_css_main_element=”width: 100% !important;||letter-spacing: -0.5px;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Courses” button_alignment=”center” module_class=”df-button dfc-servicios” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px|6px|10px|6px|false|true” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Main publications” button_alignment=”center” module_class=”df-button dfc-publicaciones” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px|6px|10px|6px|false|true” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Carlos Escande, PhD” position=”Head ” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Escande-Carlos.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/carlos-escande\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” sticky_enabled=”0″]<\/p>\n

escande@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ module_class=”dfc-investigacion” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Projects<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

TMEM176b<\/strong>: a new regulator of inflammation and insulin resistance during obesity. Co-PI: Marcelo Hill (LIRI). International funds and own resources.<\/p>\n

Role of FSTL1 in the regulation of adipogenesis and adipose tissue function during obesity<\/strong>. Co-PI: Jos\u00e9 Badano (GMH). Funded by own resources. International grant (ADA, USA).<\/p>\n

Evaluation of new anti-inflammatory compounds for the treatment of metabolic diseases<\/strong>. Co-PI: Carlos Batthy\u00e1ny (UBYPA). Funded by a private international company.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” custom_margin=”74px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Since its creation, the program has achieved the following milestones:<\/p>\n