{"id":4718,"date":"2022-03-16T14:42:41","date_gmt":"2022-03-16T14:42:41","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/redox-biology-of-trypanosomes\/"},"modified":"2026-04-13T14:19:35","modified_gmt":"2026-04-13T17:19:35","slug":"redox-biology-of-trypanosomes","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/laboratories\/redox-biology-of-trypanosomes\/","title":{"rendered":"Redox Biology of Trypanosomes"},"content":{"rendered":"

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Redox Biology of Trypanosomes<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

By means of a multidisciplinary approach, we study the biochemical, structural and biological features that distinguish several key components of the redox system from pathogenic trypanosomatids, parasites that are causative agents of severe diseases in animals and humans (Chagas disease, Leishmaniasis and African sleeping sickness).<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

These studies allow us to identify and understand the role these components play in parasite biology (e.g. growth, infection, and pathogenesis).<\/p>\n

<\/p>\n

Our research aims to gain understanding into the redox biology of trypanosomatids to guide novel strategies and the development of the safer and more efficacious drugs against this disease.<\/p>\n

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custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Marcelo Comini, PhD” position=”Head ” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Comini-Marcelo.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/marcelo-comini\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mcomini@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Andrea Medeiros, PhD” position=”Associate researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Medeiros-Andrea.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Medicine, Udelar
amedeiros@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Mariana Bonilla, PhD” position=”Associate researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Bonilla-Mariana.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mbonilla@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Diego Ben\u00edtez, PhD” position=”Research assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Benitez-Diego.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Postdoc
dbenitez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Estefan\u00eda Dibello, PhD” position=”Honorary research associate” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Dibello-Estefania.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Chemistry, Udelar
edibello@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Gonzalo Scalese, PhD” position=”Postdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2023\/08\/Scalese-Gonzalo-1.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

gscalese@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Natalia Oddone, PhD” position=”Research assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Oddone-Natalia.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

noddone@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Josu\u00e9 Burneo” position=”Estudiante de doctorado” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Burneo-Josue-ajustada.jpg” _builder_version=”4.27.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” sticky_enabled=”0″]<\/p>\n

jburneo@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Jonathan Bastidas, Ing” position=”Master’s degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/09\/Jonathan-Bastidas.jpg” _builder_version=”4.27.0″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

jbastidas@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][et_pb_team_member name=”Bruno Manta, PhD” position=”Investigador adjunto” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Manta-Bruno.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

bmanta@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][et_pb_team_member name=”Marisabel Charlo, PhD” position=”Pasante” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/03\/M-Charlo.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mcharlo@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Johana Ebert” position=”Estudiante tesista de grado” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/03\/Johana-Ebert-.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

jebert@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][et_pb_team_member name=”Valeria Florez, MSc” position=”Asistente de investigaci\u00f3n” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/04\/Florez-Valeria.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

vflorez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][et_pb_team_member name=”Pilar Terra” position=”Pasante de investigaci\u00f3n” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/icono-persona.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

pterra@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Francisco Delgado” position=”Estudiante tesista de grado” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/06\/unnamed-4.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

fdelgado@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][et_pb_team_member name=”Bel\u00e9n M\u00e1rquez ” position=”Master’s degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/03\/Marquez-Belen.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

bmarquez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][et_pb_team_member name=”Mar\u00eda Karla Castro” position=”Pasante” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Castro-Maria-Karla-1.jpg” _builder_version=”4.27.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mkcastro@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Aliana Etcheverry” position=”Master’s degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/09\/fOTO.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

aetcheverry@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][et_pb_team_member name=”Pilar Casal” position=”Pasante de grado” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/10\/Pilar-Casal.png” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

pcasal@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

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Fundamental aspects of trypanothione metabolism: synthesis, reduction and utilization<\/strong>
We study the biochemical, structural and biological features that distinguish several key components of the trypanothione system from pathogenic trypanosomatids. Using animal infection models, we investigate the role these molecules play in parasite biology and pathogenesis. The data from these studies allows to validate new drug target candidates, their inhibitors as well as to guide novel drug development strategies.<\/p>\n

<\/p>\n

Development of biosensors for non-invasive and high-content studies<\/strong>
Our laboratory is interested in the development of different types of biosensors (fluorescence- and luminescence-based) that allow the real time and non-invasive monitoring of parasite proliferation, redox state and major signaling pathways. The transgenic cell lines expressing the biosensors allow us to study the role played by the oxidative stress and redox signaling in a variety of cellular processes (e.g. host-pathogen interaction, cell differentiation, cell cycle, apoptosis and metabolic dysfunction). The reporter cell lines are also used in phenotypic drug-screening campaigns and to investigate drug mode of action.<\/p>\n

<\/p>\n

Early phase drug discovery projects<\/strong>
We apply target- and phenotypic-based approaches to screen synthetic and natural compounds that affect, in a selective manner, the growth of the infective form of different trypanosomatid species.
Drug repurposing is also an active area of research in our lab. Drug mode of action at cellular and enzymatic level is addressed to foster and guide drug optimization. Our laboratory relies on an important network of local and international groups working on (medicinal) chemistry to fulfill this goal.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-cursos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Courses<\/h2>\n

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    \n
  • \u201cRedox Chemistry and Biology of Thiols\u201d-III International Theoretical and Practical Course. February 18-28, 2019. Institut Pasteur Montevideo, Uruguay.<\/li>\n
  • \u201cInternational Course: Clinical Flow Cytometry\u201d, October 1-5, 2018, Montevideo, Uruguay.<\/li>\n
  • \u201cVII International Course on Trypanosomatid Molecular\u201d, Nov26-Dec1\u00b0, 2018, Montevideo, Uruguay.<\/li>\n
  • \u201cTheoretical and practical course on lab animals\u201d, March 13-21, 2017, Montevideo, Uruguay.<\/li>\n
  • \u201cCell and Animal Models for Drug Discovery\u201d October 16-27, 2017, Montevideo, Uruguay.<\/li>\n
  • \u201cIntegrating IP Montevideo technologies\u201d, September 8, 2017, Montevideo, Uruguay.<\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Projects<\/h2>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2023-2025 <\/strong>\u2013 Inhibidores de la MPro de SARS-CoV-2 identificados en una campa\u00f1a nacional de cribado: modo de inhibici\u00f3n y uni\u00f3n a su diana molecular, CSIC I+D, Medeiros A., Comini M.<\/p>\n

    <\/p>\n

    2023-2025 <\/strong>\u2013 Dise\u00f1o y preparaci\u00f3n de selenosemicarbazonasy sus complejos met\u00e1licos como inhibidores de proteasas de SARS-CoV2. CSIC I+D. Mahler G, OteroL.<\/p>\n

    <\/p>\n

    2023-2025 <\/strong>\u2013 Potenciales agentes antimicrobianos presentes en alimentos vegetales de inter\u00e9s regional (REDALIM-MIC), CYTED, Sulzen V.<\/p>\n

    <\/p>\n

    2023-2025 <\/strong>\u2013 Tripanosomiasis olvidadas: Expandiendo el espacio qu\u00edmico de potenciales agentes tripanosomicidas con estrategias de inteligencia artificial, in silico, s\u00edntesis, bioqu\u00edmicas y parasitol\u00f3gicas. CSIC I+D, Paulino M.<\/p>\n

    <\/p>\n

    2023-2025 <\/strong>\u2013 S\u00edntesis de una nueva serie de oligamidasan\u00e1logas a distamicina como potenciales antitripanosom\u00e1tidos
    CSIC I+D, Scarone L.<\/p>\n

    <\/p>\n

    2023-2025 <\/strong>\u2013 Desarrollo de un ensayo serol\u00f3gico r\u00e1pido para determinar la actividad neutralizante frente a diferentes variantes de SARS-CoV-2. ANII-FMV, Carri\u00f3n F.<\/p>\n

    <\/p>\n

    2022-2024<\/strong> \u2013 Metagen\u00f3mica aplicada al descubrimiento de nuevas enzimas redox. ANII FCE_1_2021_1_166635, B. Manta.<\/p>\n

    <\/p>\n

    2022-2024<\/strong> \u2013 Intestinal organoid models for studying host-parasite interaction in Chagas disease. Institut Pasteur International Network, M. Bollati.<\/p>\n

    <\/p>\n

    2021-2024<\/strong> \u2013 Structural elucidation of trypanosomatid\u00b4s molecular targets, SSGCID (contract HHSN272201700059C), Staker B, Subramanian S, Comini MA.<\/p>\n

    <\/p>\n

    2021-2023<\/strong> \u2013 Investigating the role of organic peroxides and mercaptopyruvate\/hydrogen sulphide in cell signalling, oxidative stress and drug-resistance addressed with novel genetically-encoded biosensors. Institut Pasteur International Network, M. Comini.<\/p>\n

    <\/p>\n

     <\/p>\n

    <\/p>\n

     <\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”3px|||||” custom_padding=”0px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2019-2021<\/strong> \u2013 Synthesis and study of new bensoisothiazolone derivatives as multitarget trypanosomatid agents. CSIC I+D 2018. Role: co-responsible.<\/p>\n

    <\/p>\n

    2019-2021<\/strong> \u2013 MULTI-TARGET QUINONES FOR THE DEVELOPMENT OF TRYPANOSOMIDAL DRUGS. CSIC I+D 2018. Role: collaborator.<\/p>\n

    <\/p>\n

    2019-2021<\/strong> \u2013 Inference and Comparison of Kinetic and Evolutionary Models of Proteasome Catalytic Cores. CSIC I+D 2018. Role: collaborator.<\/p>\n

    <\/p>\n

    2019-2021<\/strong> \u2013 Generation of extracts rich in polyphenols from grape pomace. Alliance for Innovation- Technological Development Modality. ANII ALI_2_2018_1_149574. Role: collaborator.<\/p>\n

    <\/p>\n

    2018-2020<\/strong> \u2013 \u201cStructure-based design of chemical compounds against human pathogen parasites from the Trypanosomatida Order\u201d. Deutsche Forschungsgemeinschaft (DFG or German research Agency) 2018-2020, 352,050 \u20ac. Role: collaborator.<\/p>\n

    <\/p>\n

    2016-2019<\/strong> \u2013 Design and production of new variants of the follicle stimulating hormone (FSH) for its use in species of productive interest. Alliance for Innovation- Technological Development Modality, ANII. $U 640.000 ALI_1_2015_1_5084. Role: collaborator.<\/p>\n

    <\/p>\n

    2015-2018<\/strong> \u2013 Design of novel biosensors for simultaneous monitoring of redox and cAMP signalling: from the computer to the cell and back to the computer. Fondo Mar\u00eda Vi\u00f1a, ANII, FMV_1_2014_1_104000, $U 1.300.000. Role: collaborator.<\/p>\n

    <\/p>\n

    2015-2017<\/strong> \u2013 The thioredoxin-fold diversity in trypanosomatids and tapeworms. Project ICGEB CRP\/URU 14-01\u2013, 2015-2017, \u20ac 45000. Role: co-responsible.<\/p>\n

    <\/p>\n

    2015-2017<\/strong> \u2013 Target-based drug discovery of compounds interfering with trypanothione biosynthesis in trypanosomatids. ACIP Grant \u2013 Project A-17-2015. \u20ac 70,000. Role: responsible.<\/p>\n

    <\/p>\n

    2014-2016<\/strong> \u2013 Trypanosoma\u00b4s prostaglandin metabolism: role in infection, pathogenesis and drug resistance\u201d, Fiocruz-Pasteur Grant, \u20ac 18,000. Role: responsible.<\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||26px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Main publications<\/h2>\n

    [\/et_pb_text][et_pb_accordion icon_color=”#005293″ _builder_version=”4.27.6″ _module_preset=”default” toggle_text_color=”#005293″ toggle_font=”Titillium Web|600|||||||” toggle_font_size=”17px” custom_margin=”||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_accordion_item title=”vacio” open=”on” _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display:none” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_accordion_item][et_pb_accordion_item title=”2026″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

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    • \n

      \u00a0Scalese G, Soba M, Zhang Y, Ben\u00edtez D,\u00a0\u00a0<\/span>Machado I, P\u00e9rez-D\u00edaz L, Cariou K, Gasser G, Comini MA, Gambino D (2026).\u00a0<\/span>\u00a0<\/span>Re(I) tricarbonyl multifunctional complexes: Effects on the infective stages <\/span><\/span>of trypanosomatids and tumor cells. J Organometal Chem 1052: 124113.<\/span><\/p>\n<\/li>\n

    • \n

      <\/span><\/span>\u00a0Sardi F, Elso O, Fiestas L, Perelmuter K, Ben\u00edtez D, Corlatti AM, Da Costa FB, Lenz M, Schmidt TJ, Bollati-Fogol\u00edn M, Medeiros A, S\u00fclsen VP, Comini MA (2026) Insights into the Chemico-Biological Interactions of Natural Sesquiterpene Lactones with the Thiol-Redox Metabolism of Pathogenic Trypanosomatids. Chem Med Chem.\u00a0e202500618: 1-10.<\/span><\/p>\n<\/li>\n

    • \n

      <\/span>\u00a0Sardi F, Quiroga C, Oddone N, Comini MA (2026) Noninvasive, Fluorescence-Based Detection of Perturbations in the Thiol-Redox Homeostasis of Bloodstream Trypanosoma brucei brucei. Methods Mol Biol. 3014:301-323.<\/span><\/p>\n<\/li>\n

    • \n

      <\/span><\/span>Colobbio M, Teixeira R, Duarte G, Silvera M, Salda\u00f1a JC, Nieves M, Medeiros A, Comini MA, Dom\u00ednguez L, Melian ME, Mungu\u00eda B, Ramos JC, Manta E (2026) Fenbendazole-amino acid derivatives as novel anthelmintic candidates: Synthesis, activity against Haemonchus contortus, and in silico profiling. Eur J Med Chem. 301:118247.\u00a0\u00a0<\/span><\/span><\/p>\n<\/li>\n

    • \n

      <\/span><\/span><\/span>Bassetti L, Crispo M, Bollati Fogol\u00edn M, Pantano S, Comini MA, Abreu C (2026) Exploring elastin-like polypeptide tags and mini-intein for recombinant protein purification in Leishmania tarentolae. Protein Expr Purif. 241:106902.<\/span><\/p>\n<\/li>\n<\/ul>\n

      [\/et_pb_accordion_item][et_pb_accordion_item title=”2025″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

        \n
      • Piattoni CV, Abreu C, Machado MR, Pantano S,\u00a0Comini\u00a0MA, Bollati-Fogol\u00edn M.\u00a0 (2025) A red-shifted biosensor for intracellular detection of cAMP: the CUTieR the better. Biochem Biophys Res Commun. 766:151831.<\/li>\n
      • Quiroga C, Incerti M, Ben\u00edtez D, Luzardo M, Manta E, Leyva A, Paulino M,\u00a0<\/span>Comini<\/span>\u00a0<\/span>MA, Medeiros A. (2025) Restyling an old scaffold: Ebsulfur analogs with improved activity and selectivity against the infective stage of trypanosomes. Eur J Med Chem. 292:117675.<\/li>\n
      • Zhong S, Kalamatianou A, Scalese G, O’Beirne C, Redrado M, Blacque O, Picot C, Tomasoni C, Log\u00e9 C, Albassier M, Ourliac-Garnier I, Pagniez F, Le Pape P, P\u00e9rez-D\u00edaz L, Gambino D, Comini MA, Cariou K, Gasser G. (2025) Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold. Inorg Chem. 64(31):16192-16203.<\/li>\n
      • D\u00e1vila B, Fl\u00f3 M, Ruatta S, Lorenzelli F, Medeiros A, Bastidas J, Rodr\u00edguez G, Aguilera E, Garc\u00eda MF, Romero AH, Park S, Heo J, Lee H, Jeon Y, Park KP, Shum D, L\u00f3pez V, Couto M, Cerecetto H, Comini MA (2025) Unveiling novel pharmacophores and hit compounds for the development of anti-virals to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Bioorg Chem. 163:108724.<\/li>\n<\/ul>\n

        [\/et_pb_accordion_item][et_pb_accordion_item title=”2024″ _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

          \n
        • Ben\u00edtez D, Ort\u00edz C, Dibello E and Comini MA (2024) Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis. Front. Chem. Biol 3:1433511.<\/li>\n
        • Quiroga C, Incerti M, Benitez D, Manta E, Medeiros A, Comini MA (2024) Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening. Front. Chem. Biol 3:1423430.<\/li>\n
        • Rivas F, Del M\u00e1rmol C, Scalese G, P\u00e9rez D\u00edaz L, Machado I, Blacque O, Salazar F, Coiti\u00f1o EL, Ben\u00edtez D, Medeiros A, Comini M, Gambino D. (2024) Multifunctional Organometallic Compounds Active against Infective Trypanosomes: Ru(II) Ferrocenyl Derivatives with Two Different Bioactive Ligands. Inorg Chem. 63(25):11667- 11687.<\/li>\n
        • Abreu A, Grunberg K, Bonilla M, Crispo M, Pantano S, Jaeschke J, Comini MA*, Bollati-Fogol\u00edn M (2024) Expression and Functional Characterization of Chimeric Recombinant Bovine Follicle-Stimulating Hormone Produced in Leishmania tarentolae. Microb. Biotech. 17:e14444.<\/li>\n
        • Dibello E, Oddone N, Franco J, Illy\u00e9s T-Z, Medeiros A, Kiss A, H\u0151gye F, K\u00f6v\u00e9r KE, Szil\u00e1gyi L, Comini MA* (2024) Selenosugars Targeting the Infective Stage of Trypanosoma brucei with High Selectivity. Int J Parasitol Drugs Drug Resist, 24: 100529.<\/li>\n<\/ul>\n

          [\/et_pb_accordion_item][et_pb_accordion_item title=”2023″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

            \n
          • Prada Gori DN, Ruatta S, Fl\u00f3 M, Alberca LN, Bellera CL, Park S, Heo J, Lee H, Park K-HP, Pritsch O, Shum D, Comini MA and Talevi A (2023) Drug repurposing screening validated by experimental assays identifies two clinical drugs targeting SARS-CoV-2 main protease. Front. Drug. Discov. 2:1082065.<\/li>\n
          • Ballesteros-Casallas A, Quiroga C, Ortiz C, Ben\u00edtez D, Denis PA, Figueroa D, Salas CO, Bertrand J, Tapia RA, S\u00e1nchez P, Miscione GP, Comini MA, Paulino M. (2023) Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models. Eur J Med Chem. 246:114926.<\/li>\n
          • Favaro A, Bolcato G, Comini MA, Moro S, Bellanda M, Sturlese M. (2023) Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1. Molecules 28(3):1276.<\/li>\n
          • Lindhof JC, Ihnatenko I, M\u00fcller MJ, Orban OCF, Ort\u00edz C, Ben\u00edtez D, Dibello E, Seidl LL, Comini MA, Kunick C (2023) Discovery of Antitrypanosomal Indolylacetamides by a Deconstruction-Optimization Strategy Applied to Paullones. ChemMedChem. e202300036.<\/li>\n
          • Daghero H, Pagotto R, Quiroga C, Medeiros A, Comini MA, Bollati-Fogol\u00edn M. (2023) Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium. Front Cell Infect Microbiol. 13:1082524.<\/li>\n
          • Ruatta SM, Prada Gori DN, Fl\u00f3 D\u00edaz M, Lorenzelli F, Perelmuter K, Alberca LN, Bellera CL, Medeiros A, L\u00f3pez GV, Ingold M, Porcal W, Dibello E, Ihnatenko I, Kunick C, Incerti M, Luzardo M, Colobbio M, Ramos JC, Manta E, Minini L, Lavaggi ML, Hern\u00e1ndez P, \u0160arlauskas J, Huerta Garc\u00eda CS, Castillo R, Hern\u00e1ndez-Campos A, Ribaudo G, Zagotto G, Carlucci R, Medr\u00e1n NS, Labadie GR, Martinez-Amezaga M, Delpiccolo CML, Mata EG, Scarone L, Posada L, Serra G, Calogeropoulou T, Prousis K, Detsi A, Cabrera M, Alvarez G, Aicardo A, Ara\u00fajo V, Chavarr\u00eda C, Ma\u0161i\u010d LP, Gantner ME, Llanos MA, Rodr\u00edguez S, Gavernet L, Park S, Heo J, Lee H, Paul Park K-H, Bollati-Fogol\u00edn M, Pritsch O, Shum D, Talevi A and Comini MA* (2023), Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARSCoV-2 MPro. Front. Pharmacol. 14:1193282.<\/li>\n
          • Gonzalez AC, Abreu C, Pantano S, Comini M, Malacrida L, Egger B, Cantera R, Prieto D. (2023) A FRET-based cGMP biosensor in Drosophila. MicroPubl Biol. 2023:10.17912\/micropub.<\/span>biology.000887.<\/span><\/li>\n
          • Ihnatenko I, M\u00fcller MJ, Orban OCF, Lindhof JC, Ben\u00edtez D, Ort\u00edz C, Dibello E, Seidl LL, Comini MA, Kunick C. (2023) The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones. PLoS One 18(11):e0292946.<\/li>\n<\/ul>\n

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            • Barreiro-Costa O, Quiroga Lozano C, Mu\u00f1oz E, Rojas-Silva P, Medeiros A, Comini MA, Heredia-Moya J (2022) Evaluation of the anti-Leishmania mexicana and -Trypanosoma brucei activity, and mode of action of 4,4\u2032-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol). Biomedicines, 1760532.<\/li>\n
            • Ben\u00edtez D, Franco J, Sardi F, Leyva A, Dur\u00e1n R, Choi G, Yang G, Kim T, Kim N, Heo J, Kim K, Lee H, Choi I, Radu C, Shum D, No JH, Comini MA (2022) Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening. J Enzyme Inhib Med Chem, 37(1):912-929.<\/li>\n
            • Perelmuter K, Tiscornia I, Comini MA, Bollati-Fogol\u00edn M (2022) Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance. Sensors, 22(4):1324.<\/li>\n
            • Pazos M, Dibello E, Mesa JM, Sames D, Comini MA, Seoane G, Carrera I (2022) Iboga Inspired N-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents. Molecules, 27(3):829.<\/li>\n
            • Dibello E.; Comini M.A., Ben\u00edtez D (2022) A simple, robust and affordable bioluminescent assay for drug screening against infective African trypanosomes. Methods Mol Biol, 2524: 149-162.<\/li>\n
            • Ben\u00edtez, D.; Medeiros, A.; Quiroga, C.; Comini, M.A.. (2022) A simple bioluminescent assay for the screening of cyto-toxic molecules against the intracellular form of Leishmania infantum. Methods Mol Biol, 2524: 127-147.<\/li>\n
            • Ben\u00edtez D, Dibello E, Bonilla M, Comini MA. (2020) A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes. Drug Dev Res, 83: 253-263.<\/li>\n
            • Comini MA (2022) Polyamine-based thiols in pathogens. In: Redox Chemistry and Biology of Thiols, Ed. Alvarez B, Comini MA, Salinas G, Trujillo M. Academic Press. Chapter 24: 555-584. ISBN 9780323902199.<\/li>\n
            • Ort\u00edz, C., Ruatta, S., Comini, M. (2022). Introduction to Target Validation. In: Scotti, M.T., Bellera, C.L. (eds) Drug Target Selection and Validation. Computer-Aided Drug Discovery and Design, vol 1. Springer, Cham. Chapter 4: 61-82. ISBN: 978-3-030-95894-7.<\/li>\n
            • Alvarez B, Comini MA, Salinas G, Trujillo M (2022) Redox Chemistry and Biology of Thiols: 1st Edition. Academic Press. ISBN: 9780323902199<\/li>\n
            • Phan TN, Park KP, Ben\u00edtez D, Comini MA, Shum D, No JH. (2022) Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening. Biochem Biophys Res Commun. 637:308-313.<\/li>\n
            • Rivas F, Del M\u00e1rmol C, Scalese G, P\u00e9rez-D\u00edaz L, Machado I, Blacque O, Medeiros A, Comini M, Gambino D. (2022) New multifunctional Ru(II) organometallic compounds show activity against Trypanosoma brucei and Leishmania infantum. J Inorg Biochem. 237:112016.<\/li>\n<\/ul>\n

              [\/et_pb_accordion_item][et_pb_accordion_item title=”2021″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

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              • Specker G, Piacenza L, Radi R, Comini MA (2021) Thiol-Disulphide Redox Signalling\/Control during the Life Cycle of Pathogenic Trypanosomatids. In: Redox regulation of differentiation and de-differentiation, Ed. Berndt C and Lillig CH, CRC Press, Taylor & Francis Group, Chapter 3: 37-55 eBook ISBN 9781003204091.<\/li>\n
              • Prolo C, Estrada D, Piacenza, L, Ben\u00edtez D, Comini, MA, Radi R, \u00c1lvarez MN (2021) NOX2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection. Redox Biology, 2021 46: 102085 DOI: 10.1016\/j.redox.2021.10208.<\/li>\n
              • Alice JI, Bellera CL, Ben\u00edtez D, Comini MA, Duchowicz PR, Talevi A (2021) Ensemble learning application to discover new trypanothione synthetase inhibitors. Mol Divers. 2021 25: 1361-1373 DOI: 10.1007\/s11030-021-10265-9.<\/li>\n
              • Bellera CL, Llanos M, Gantner ME, Rodriguez S, Gavernet L, Comini M, Talevi A (2021) Can drug repurposing strategies be the solution to the COVID-19 crisis? Expert Opin Drug Discov. 16(6):605-612 DOI: 10.1080\/17460441.2021.1863943.<\/li>\n
              • Klein F, Sardi F, Machado MR, Ortega C, Comini MA, Pantano S (2021) CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones. Front Mol Biosci. 8:629773 DOI: 10.3389\/fmolb.2021.629773.<\/li>\n
              • Rivas F, Medeiros A, Quiroga C, Ben\u00edtez D, Comini M, Rodr\u00edguez-Arce E, Machado I, Cerecetto H, Gambino D (2021) New Pd-Fe ferrocenyl antiparasitic compounds with bioactive 8-hydroxyquinoline ligands: a comparative study with their Pt-Fe analogues. Dalton Trans. 50(5):1651-1665 DOI: 10.1039\/d0dt03963b.<\/li>\n
              • Ort\u00edz C, Moraca F, Laverriere M, Jordan A, Hamilton N, Comini MA (2021) Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei. Molecules 26(2):358 DOI: 10.3390\/molecules26020358.<\/li>\n
              • Niborski LL, Potenza M, Chirivi RGS, Simonetti L, Ossowski MS, Grippo V, May M, Staquicini DI, Parodi-Talice A, Robello C, Comini MA, Alonso GD, Raats JMH, G\u00f3mez KA. Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system. EBioMedicine 63:103206 DOI: 10.1016\/j.ebiom.2020.103206.<\/li>\n<\/ul>\n

                [\/et_pb_accordion_item][et_pb_accordion_item title=”2020″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

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                • Medeiros A, Ben\u00edtez D, Korn RS, Ferreira VC, Barrera E, Carri\u00f3n F, Pritsch O, Pantano S, Kunick C, de Oliveira CI, Orban OCF, Comini MA (2020) Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania. J Enzyme Inhib Med Chem. 35(1):1345-1358 DOI: 10.1080\/14756366.2020.1780227.<\/li>\n
                • Benitez D, Comini MA, Anusevi\u010dius \u017d, \u0160arlauskas J, Miliukien\u0117 V, Miliuvien\u0117 E, \u010c\u0117nas N (2020). Chemija 31(2), 111-117 DOI: 10.6001\/chemija.v31i2.4223.<\/li>\n
                • Parakh S, Shadfar S, Perri ER, Ragagnin AMG, Piattoni CV, Fogol\u00edn MB, Yuan KC, Shahheydari H, Don EK, Thomas CJ, Hong Y, Comini MA, Laird AS, Spencer DM, Atkin JD (2020). The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models. iScience 23(5):101097 DOI: 10.1016\/j.isci.2020.101097.<\/li>\n
                • Franco J, Scarone L, Comini MA (2020) Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency. Eur J Med Chem. 189: 112043. DOI: 10.1016\/j.ejmech.2020.112043.<\/li>\n<\/ul>\n

                  [\/et_pb_accordion_item][et_pb_accordion_item title=”2019″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

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                  • Talevi A, Carrillo C, Comini MA (2019) The thiol-polyamine metabolism of Trypanosoma cruzi: molecular targets and drug repurposing strategies. Curr. Med. Chem. 26: 1-20 DOI: 10.2174\/0929867325666180926151059.<\/li>\n
                  • Currier RB, Ulrich K, Leroux AE, Dirdjaja N, Deambrosi M, Bonilla M, Ahmed YL, Adrian L, Antelmann H, Jakob U, Comini MA, Krauth-Siegel RL (2019) An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone. PLoS Pathog. 15(9):e1008065.<\/li>\n
                  • Rivas F, Medeiros A, Comini M, Suescun L, Rodr\u00edguez Arce E, Martins M, Pinheiro T, Marques F, Gambino D (2019) Pt-Fe ferrocenyl compounds with hydroxyquinoline ligands show selective cytotoxicity on highly proliferative cells. J Inorg Biochem. 199:110779.<\/li>\n
                  • Vairoletti F, Medeiros A, Font\u00e1n P, Mel\u00e9ndrez J, Tab\u00e1rez C, Salinas G, Franco J, Comini MA, Salda\u00f1a J, Jancik V, Mahler G, Saiz C (2019) Synthesis of bicyclic 1,4-thiazepines as novel anti-Trypanosoma brucei brucei agents. Med Chem Comm. 10: 1481-1487.<\/li>\n
                  • Rodr\u00edguez Arce E, Putzu E, Lapier M, Maya JD, Olea Azar C, Echeverr\u00eda GA, Piro OE, Medeiros A, Sardi F, Comini M, Risi G, Salinas G, Correia I, Pessoa JC, Otero L, Gambino D. New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents. Dalton Trans. 2019 May 3. doi: 10.1039\/c9dt01317b. [Epub ahead of print] PubMed PMID: 31049548.<\/li>\n
                  • \u00a0<\/li>\n
                  • Ort\u00edz C, Botti H, Buschiazzo A, Comini MA (2019) Glucose-6-Phosphate Dehydrogenasefrom the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features toSupport Efficient Product Formation. J Mol Biol. 431(11): 2143-2162<\/li>\n
                  • Ferrer MJ, Wehrendt DP, Bonilla M, Comini MA, Tellez-I\u00f1\u00f3n MT, Potenza M (2019) Production of recombinant Trypanosoma cruzi antigens in Leishmania tarentolae. Methods Mol. Biol. 1955: 105-118.<\/li>\n
                  • Piattoni CV, Sardi F, Klein F, Pantano S, Bollati-Fogolin M, Comini MA. (2019) New red-shifted fluorescent biosensor for monitoring intracellular redox changes. Free Radic Biol Med. 134:545-554.<\/li>\n
                  • Manta B, M\u00f6ller MN, Bonilla M, Deambrosi M, Grunberg K, Bellanda M, Comini MA, Ferrer-Sueta G (2019) The key role of a redox- active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites revealed by kinetics. J. Biol. Chem. 294: 3235-3248.<\/li>\n
                  • Mes\u00edas AC, Sasoni N, Arias DG, P\u00e9rez Brand\u00e1n C, Orban OCF, Kunick C, Robello C, Comini MA, Garg NJ, Zago MP (2019) Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi. Free Radic Biol Med. 130: 23-34.<\/li>\n<\/ul>\n

                    [\/et_pb_accordion_item][et_pb_accordion_item title=”2018″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

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                    • Talevi A, Carrillo C, Comini MA (2018) The thiol-polyamine metabolism of Trypanosoma cruzi: molecular targets and drug repurposing strategies. Curr. Med. Chem. 26: 1-20.<\/li>\n
                    • Sturlese M, Manta B, Bertarello A, Bonilla M, Lelli M, Zambelli B, Grunberg K, Mammi S, Comini M, Bellanda M (2018) Monothiol glutaredoxin 1 from trypanosomes contains a lineage-specific, intrinsically disordered, regulatory region. Sci. Rep. 8: 13716<\/li>\n
                    • Rivas F, Medeiros A, Rodr\u00edguez Arce E, Comini MA, Ribeiro CM, Pavan FR, Gambino D (2018) New heterobimetallic ferrocenyl derivatives: evaluation of their potential as prospective agents against trypanosomatid parasites and Mycobacterium tuberculosis. J. Inorg. Biochem. 187: 73-84.<\/li>\n
                    • Ebersoll S, Musunda B, Schmenger T, Dirdjaja N, Bonilla M, Manta B, Comini MA, Krauth-Siegel RL (2018) A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes. Redox Biology 15: 532-547.<\/li>\n
                    • Salinas G, Comini MA (2018) Alternative thiol-based redox systems. Antioxid Redox Signal. 28: 407-409.<\/li>\n
                    • Manta B, Bonilla M, Fiestas L, Sturlese M, Salinas G, Bellanda M, Comini MA. (2018) Polyamine-based thiols in Trypanosomatids: evolution, protein structural adaptations and biological functions. Antioxid Redox Signal. 28: 463-486.<\/li>\n
                    • Franco J, Scarone L, Comini MA (2018) Drugs and drug resistance in African and American trypanosomiasis. In: Annual Reports in Medicinal Chemistry: Medicinal Chemistry Approaches To Overcome Antibiotic Resistance volume 51, Ed. Botta, M., Academic Press, Elsevier, Chapter 3: 97-133.<\/li>\n
                    • Comini MA (2018) Biosynthesis of Polyamine\u2013Glutathione Derivatives in Enterobacteria and Kinetoplastida. In: Glutathione, Ed. Floh\u00e9, L., CRC Press: Boca Raton, pp. 285-305.<\/li>\n<\/ul>\n

                      [\/et_pb_accordion_item][et_pb_accordion_item title=”2017″ _builder_version=”4.16″ _module_preset=”default” link_option_url_new_window=”on” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

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                      • Franco J, Sardi F, Szil\u00e1gyi L, K\u00f6v\u00e9r K, Feh\u00e9r K, Comini MA (2017) Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes. Int. J. Parasitol. Drugs & Drug Resist. 7: 303-313.<\/li>\n
                      • Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony (2017) Fonseca MS, Comini M, Resende BV, Santi AMM, Zoboli AP, Moreira DS, Monte-Neto RL and Murta SMF. Exp. Parasitol. 175: 36-43.<\/li>\n
                      • Franco J, Medeiros A, Ben\u00edtez D, Perelmuter K, Serra G, Comini MA, Scarone L (2017) In vitro activity and mode of action of Distamycin analogues against African trypanosomes. Eu. J. Med. Chem. 126: 776-788.<\/li>\n<\/ul>\n

                        [\/et_pb_accordion_item][et_pb_accordion_item title=”2016″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

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                        • Orban OCF, Korn RS, Ben\u00edtez D, Medeiros A, Preu L, Loa\u00ebc N, Meijer L, Koch O, Comini MA, and Kunick C (2016) 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms. Bioorg Med Chem. 24(16):3790-800.<\/li>\n
                        • Ben\u00edtez D, Medeiros A, Fiestas L, Panozzo-Zenere EA, Maiwald F, Prousis KC, Roussaki M, Calogeropoulou T, Detsi A, Jaeger T, \u0160arlauskas J, Peterlin Ma\u0161i\u010d L, Kunick C, Labadie GR, Floh\u00e9 L, Comini MA. (2016) Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids. PLoS Negl Trop Dis. 10(4): e0004617. http:\/\/journals.plos.org\/plosntds\/article?id=10.1371\/journal.pntd.0004617<\/li>\n
                        • Ortiz C, Moraca F, Medeiros A, Botta M, Hamilton N, Comini M. (2016) Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi. Molecules 21(3), 368; http:\/\/www.mdpi.com\/1420-3049\/21\/3\/368.<\/li>\n
                        • Bonilla M, Krull E, Irigo\u00edn F, Salinas G, Comini MA. (2016) Selenoproteins of African trypanosomes are dispensable for parasite survival in an animal host. Mol Biochem Parasitol. 206(1-2): 13-19.<\/li>\n
                        • Alberca LN, Sbaraglini ML, Balcazar D, Fraccaroli L, Carrillo C, Medeiros A, Benitez D, Comini M, Talevi A. (2016) Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning. J Comput Aided Mol Des. 30(4): 305-321.<\/li>\n
                        • Comini MA (2016) Measurement and meaning of cellular thiol:disufhide redox status. Free Radic Res. 50(2): 246-71.<\/li>\n
                        • Randall L, Manta B, Nelson KJ, Santos J, Poole LB, Denicola A. (2016) Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form. Arch Biochem Biophys. 590: 101-108.<\/li>\n<\/ul>\n

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                          • Musunda B, Ben\u00edtez D, Dirdjaja N, Comini MA, Krauth-Siegel RL. (2015) Glutaredoxin-deficiency confers bloodstream Trypanosoma brucei with improved thermotolerance. Mol Biochem Parasitol. 204(2): 93-105.<\/li>\n
                          • Bisio H, Bonilla M, Manta B, Gra\u00f1a M, Salzman V, Aguilar PS, Gladyshev VN, Comini MA, Salinas G. (2015) A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters. Antioxid Redox Signal. Oct 27. [Epub ahead of print] PubMed PMID: 26381228.<\/li>\n
                          • Stefani M, Sturlese M, Manta B, L\u00f6hr F, Mammi S, Comini M, Bellanda M (2015) (1)H, (13)C and (15)N resonance assignment of the cytosolic dithiol glutaredoxin 1 from the pathogen Trypanosoma brucei. Biomol NMR Assign. 10(1): 85-88.<\/li>\n
                          • Rodr\u00edguez Arce E, Sarniguet C, Moraes TS, Vieites M, Tomaz AI, Medeiros A, Comini MA, Varela J, Cerecetto H, Gonz\u00e1lez M, Marques F, Garc\u00eda MH, Otero L, Gambino D (2015) A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites. J Coord. Chem. 1-15.<\/li>\n
                          • Fern\u00e1ndez M, Arce ER, Sarniguet C, Morais TS, Tomaz AI, Azar CO, Figueroa R, Diego Maya J, Medeiros A, Comini M, Helena Garcia M, Otero L, Gambino D. (2015) Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites. J Inorg Biochem. 153: 306-314.<\/li>\n
                          • Miserachs HG, Cipriani M, Grau J, Vilaseca M, Lorenzo J, Medeiros A, Comini MA, Gambino D, Otero L, Moreno V. (2015) Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands. J Inorg Biochem. 150: 38-47.<\/li>\n<\/ul>\n

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                            • Pe\u00f1a S., Fagundez C., Medeiros A., Comini M.A., Scarone L., Sellanes D., Manta E., Tulla-Puche J., Albericio F., Stewart L., Yardley V. and Serra G. (2014) Synthesis of Cyclohexapeptides as Promising Antimalarial and Anti-trypanosomal Agents. Med. Chem. Comm. 3: 1443-1448.<\/li>\n
                            • Sousa A.F., Gomes-Alves A.G., Ben\u00edtez D., Comini M.A., Floh\u00e9 L., Jaeger T., Passos J., Stuhlmann F., Tom\u00e1s A. M., Castro H. (2014) Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum. Free Rad. Biol. Med. 73: 229-238.<\/li>\n
                            • Maiwald F; Ben\u00edtez D; Charquero D; Abad Dar M; Erdmann H; Preu L;Koch O; Hoscher C; Meijer L; Comini MA; Kunick C (2014) 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.. Eu. J. Med. Chem. 83: 274-283.<\/li>\n
                            • Randall LM, Manta B, Hugo M, Gil M, Batthy\u00e0ny C, Trujillo M, Poole LB, Denicola A (2014) Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase. J Biol Chem. 289(22): 15536-43.<\/li>\n
                            • Sturlese M, Lelli M, Manta B, Mammi S, Comini MA, Bellanda M. (2014) (1)H, (13)C and (15)N resonance assignment of the mature form of monothiol glutaredoxin 1 from the pathogen Trypanosoma brucei. Biomol NMR Assign 9: 143-146.<\/li>\n
                            • Hiller C., Nissen A., Benitez D., Comini M., Krauth-Siegel R. L (2014) Cytosolic Peroxidases Protect the Lysosome of Bloodstream African Trypanosomes from Iron-Mediated Membrane Damage. PLoS Pathogens 10(4):e1004075.<\/li>\n<\/ul>\n

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                              • Manta B., Pavan C., Sturlese M., Medeiros A., Crispo M., Berndt C., Krauth-Siegel R.L., Bellanda M. and Comini M.A. (2013) Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity. Antioxid. Redox Signal. 19(7):665-82<\/li>\n
                              • Sardi F, Manta B, Portillo-Ledesma S, Knoops B, Comini MA, Ferrer-Sueta G. 2013. Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection. Anal Biochem. 435(1):74-82.<\/li>\n
                              • Manta B, Comini M, Medeiros A, Hugo M, Trujillo M, Radi R. 2013. Trypanothione: A unique bis-glutathionyl derivative in trypanosomatids. Biochim Biophys Acta. 1830(5):3199-216.<\/li>\n
                              • Fern\u00e1ndez M., Becco L., Correia I., Ben\u00edtez J., Piro O.E., Echeverria G.A., Medeiros A., Comini M., Lavaggi M.L., Gonz\u00e1lez M., Cerecetto H., Moreno V., Pessoa J.C., Garat B. and Gambino D. (2013) Oxidovanadium(IV) and dioxidovanadium(V) complexes of tridentate salicylaldehyde semicarbazones: Searching for prospective antitrypanosomal agents. J. Inorg Biochem. 127:150-60.<\/li>\n
                              • Comini M.A., Krauth-Siegel R.L., Bellanda M. (2013) Mono- and di-thiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes. Antiox. Redox Signal. 19(7):708-22.<\/li>\n
                              • Comini M.A, Ortiz C., Cazzulo, J.J. (2013). Drug Targets in Trypanosomal and Leishmanial Pentose Phosphate Pathway. In: Trypanosomatids diseases, molecular routes to drug discovery. Ed. T. J\u00e4ger, O. Koch, L.Floh\u00e9, Wiley-Blackwell. ISBN: 978-3-527-33255-7.<\/li>\n
                              • Comini M.A., Floh\u00e9 L. (2013). The trypanothione-based redox metabolism of trypanosomatids. In: Trypanosomatids diseases, molecular routes to drug discovery. Ed. T. J\u00e4ger, O. Koch, L.Floh\u00e9, Wiley-Blackwell ISBN: 978-3-527-33255-7.<\/li>\n<\/ul>\n

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                                • Pe\u00f1a S., Scarone L., Medeiros A., Manta E., Comini M., Serra G. 2012. Synthesis of precursors and macrocycle analogs of aerucyclamides as anti-trypanosomal agents. Med. Chem. Commun. 3(11):1443-1448<\/li>\n
                                • Demoro B., Sarniguet C., S\u00e1nchez-Delgado R., Rossi M., Liebowitz D., Caruso, F., Olea-Azar C., Moreno V., Medeiros A., Comini M.A., Otero L., Gambino D. 2012New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents. Dalton Transactions. 41(5):1534-43.<\/li>\n
                                • Manta B., Fleitas A.L., Comini M.A. (2012). Iron Metabolism in Pathogenic Trypanosomes. In: Iron Metabolism. Ed. S.Arora, InTech Press. ISBN 979-953-307-162-5.<\/li>\n
                                • Comini M.A., Medeiros A., Manta B. (2012). Stress response in the infective stage of Trypanosoma brucei. In: Stress Response in Microbiology. Ed. J.M. Requena, Horizon Scientific Press. ISBN 978-1-908230-04-1.<\/li>\n<\/ul>\n

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                                  • Ortiz C., Larrieux N., Medeiros A., Botti H., Comini M., Buschiazzo, A. 2011. Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67(Pt 11):1457-61 \/ 67(Pt 12):1674<\/li>\n
                                  • Roldan A., Comini M.A., Crispo M., Krauth-Siegel R.L. (2011) Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei. Mol. Microbiol. 81(3):623-39<\/li>\n
                                  • Manta B., Obal G., Ricciardi A., Pritsch O., Denicola A. (2011) Tools to evaluate conformation in protein products. 2011. Biotechnology Journal 6(6):731-41.<\/li>\n
                                  • Ferrer-Sueta G., Manta B., Botti H., Radi R., Trujillo M., Denicola A. 2011. Factors affecting protein thiol reactivity and specificity in peroxide reduction. Chem. Res. Tox. 24(4):434-50.<\/li>\n<\/ul>\n

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                                    • Comini M.A., Dirdjaja N., Kaschel M., Krauth-Siegel R.L., 2009. Preparative enzymatic synthesis of trypanothione and trypanothione analogues. Int. J. Parasitol. 39, 1059-1062.<\/li>\n<\/ul>\n

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                                      • Comini M.A., Rettig J., Dirdjaja N., Hanschmann E.M., Berndt C., Krauth-Siegel R.L., 2008. Monothiol Glutaredoxin-1 Is an Essential Iron-Sulfur Protein in the Mitochondrion of African Trypanosomes. J Biol. Chem. 283, 27785-27798.<\/li>\n
                                      • Irigo\u00edn F., Cibils L., Comini M.A., Wilkinson S.R., Floh\u00e9 L., Radi R., 2008. Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification. Free Radic. Biol. Med. 45, 733-742.<\/li>\n
                                      • Buchholz K., Comini M.A., Wissenbach D., Schirmer R. H., Krauth-Siegel R. L. and Gromer S. (2008) Cytotoxic interactions of methylene blue with trypanosomatids-specific disulfide reductases and their dithiol products. Mol. Biochem. Parasitol., 160: 65-69.<\/li>\n
                                      • Krauth-Siegel R. L. and Comini M.A. (2008) Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism. Biochem. Biophys. Acta, 1780: 1236-1248.<\/li>\n
                                      • Filser M., Comini M.A., Dirdjaja N., Molina-Navarro M., Herrero E., and Krauth-Siegel R. L. (2008) Cloning, functional analysis and localization of monothiol glutaredoxin-1 from Trypanosoma brucei. Biol. Chem., 389: 21-32.<\/li>\n
                                      • Bollati-Fogol\u00edn M. and Comini M. A. (2008). Chapter 3: Clonagem e Express\u00e3o de Prote\u00ednas Heter\u00f3logas em C\u00e9lulas Animais, pp. 40-76. In: Tecnologia do Cultivo de C\u00e9lulas Animais: de Biof\u00e1rmacos a Terapia G\u00eanica. Eds. \u00c2ngela Maria Moraes Elisabeth F. P. Augusto e Leda Dos Reis Castilho. Editora Roca, S\u00e3o Paulo, Brazil.<\/li>\n<\/ul>\n

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                                        • Schlecker T., Comini M.A., Melchers J., Ruppert T., and Krauth-Siegel R. L. (2007) Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei. Biochem. J., 405: 445-454.<\/li>\n
                                        • Xolalpa W., Vallecillo A., Lara M., Spallek R., Comini M., Singh M., and Espitia C. (2007) Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis. Proteomics, 7: 3332-3341.<\/li>\n
                                        • Comini M.A., Krauth-Siegel R.L., and Floh\u00e9, L. (2007) Depletion of the thioredoxin homologue tryparedoxin impairs anti-oxidative defense in African trypanosomes. Biochem. J., 402: 43-49.<\/li>\n
                                        • Bollati-Fogol\u00edn M. and Comini M. A. (2007). Chapter 3: Cloning and Expression of Heterologous Proteins in Animal Cells, pp. 39-73. In: Animal Cell Technology: From Biopharmaceuticals to Gene Therapy. Eds. Leda R. Castilho, \u00c2ngela Maria Moraes, Elisabeth F. P. Augusto and Michael Butler. Taylor & Francis, New York, US and Abingdon, UK.<\/li>\n
                                        • Schlecker T., Comini M. A., and Krauth-Siegel R. L. (2007) . Chapter 11: The trypanothione system, pp. 231-252. In: Peroxiredoxin systems: Structures and functions. Eds. Leopold Floh\u00e9 and Robin J. Harris. Springer-Verlag, Berlin, Germany.<\/li>\n<\/ul>\n

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                                          • Trujillo M., Mauri P., Benazzi L., Comini M.A., De Palma A., Floh\u00e9 L., Radi R., Stehr M., Singh M., Ursini F. and J\u00e4ger T. (2006) The mycobacterial thioredoxin peroxidase can act as a one-cysteine-peroxiredoxin. J. Biol. Chem., 281: 20555-20566.<\/li>\n<\/ul>\n

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                                            • Comini M.A., Menge U., Wissing J. and Floh\u00e9 L. (2005) Trypanothione synthesis in Crithidia revisited. J. Biol. Chem., 280: 6850-6860.<\/li>\n
                                            • Comini M.A., Menge U., and Floh\u00e9 L. (2005) \u201cConvenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata. Vol. 272 (1997) 11908\u201311915\u2033. J. Biol. Chem., 280: 7407.<\/li>\n<\/ul>\n

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                                              • Comini M.A., Guerrero S. A., Haile S., Menge U., L\u00fcnsdorf H. and Floh\u00e9 L. (2004) Validation of Trypanosoma brucei trypanothione synthetase as drug target. Free Radic. Biol. Med., 36: 1289-1302.<\/li>\n
                                              • Imaz S. M., Comini M.A., Zerbini E., Sequeira M. D., Latini O., Claus J. D. and Singh M. (2004) Evaluation of commercial ELISA kits for the detection of Tuberculosis in Argentinean population. J. Clin. Microbiol., 42: 884-887.<\/li>\n<\/ul>\n

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                                                • Comini M.A., Menge U. and Floh\u00e9 L. (2003) Biosynthesis of trypanothione in Trypanosoma brucei brucei. Biol. Chem., 384: 653-656.<\/li>\n<\/ul>\n

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                                                  • Imaz M. S., Comini M.A., Zerbini E., Sequeira M. D., Spoletti M. J., Etchart A. A., Pagano H. J., Bonifasich E., D\u00edaz N., Claus J. D. and Singh M. (2001) Evaluation of the diagnostic value of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of Mycobacterium tuberculosis in childhood tuberculosis. Int. J. Tuberc. Lung Dis., 5 (11): 1036-1043.<\/li>\n<\/ul>\n

                                                    [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

                                                    Redox Biology of TrypanosomesBy means of a multidisciplinary approach, we study the biochemical, structural and biological features that distinguish several key components of the redox system from pathogenic trypanosomatids, parasites that are causative agents of severe diseases in animals and humans (Chagas disease, Leishmaniasis and African sleeping sickness).These studies allow us to identify and understand […]<\/p>\n","protected":false},"author":2,"featured_media":1079,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[48],"tags":[],"dipi_cpt_category":[],"class_list":["post-4718","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-laboratories"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=4718"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4718\/revisions"}],"predecessor-version":[{"id":24854777,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4718\/revisions\/24854777"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media\/1079"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=4718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/categories?post=4718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/tags?post=4718"},{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=4718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}