{"id":4730,"date":"2022-03-16T18:09:56","date_gmt":"2022-03-16T18:09:56","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/glycobiology-and-tumor-immunology\/"},"modified":"2024-01-02T16:32:56","modified_gmt":"2024-01-02T16:32:56","slug":"glycobiology-and-tumor-immunology","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/previous-laboratories\/glycobiology-and-tumor-immunology\/","title":{"rendered":"Glycobiology and Tumor Immunology"},"content":{"rendered":"

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Glycobiology and Tumor Immunology<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Proteins and carbohydrates (sugars) interaction plays an essential role in several cellular processes, such as cell proliferation and differentiation, as well as in different diseases, including viruses, bacteria and parasites infections. To perform these specialized functions, some types of carbohydrates bind to proteins creating complex structures called glycoproteins, which are found on the surface of cells and which influence cellular communication. Glycobiology is a discipline that studies the structure and function of carbohydrates as entities linked to cell function.<\/p>\n

Our laboratory is focused on the identification and study of some alterations of glycosylation in cancer. Altered glycosylation produces some structures that are tumour-specific. Against them, we generate different types of biotechnological developments in view of their biomedical application. Our lines of research are oriented to understand characteristics of tumour biology and, especially, to develop new molecular procedures in view of their application to the diagnosis and treatment of the disease.<\/p>\n

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Image: <\/strong>Human colon cancer identified by anti-Trypanosoma cruzi antibodies. Left: Malignant colon tumour (positive).<\/em>Right: Adjacent normal colonic mucosa (negative).<\/em><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_gallery gallery_ids=”1998″ _builder_version=”4.14.6″ _module_preset=”00152f4d-f02d-4502-838c-0e4dc2e69425″ global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”0px||0px|0px|false|false” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_6,1_6,1_6,1_6,1_6,1_6″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.14.6″ _module_preset=”default” width=”100%” max_width=”80%” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_6″ 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dfc-publicaciones” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px|6px|10px|6px|false|true” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Eduardo Osinaga, MD, PhD” position=”Head ” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Osinaga-Eduardo.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/eduardo-osinaga\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Medicine, Udelar
<\/span>eosinaga@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Nora Berois, MD, PhD” position=”Associate researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Brois-Nora.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

\n nberois@pasteur.edu.uy<\/a>\n <\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”\u00c1lvaro Pittini, PhD” position=”Honorary researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Pittini-Alvaro.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Medicine, Udelar
apittini@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Viviana Cardozo, MSc” position=”Doctoral student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Cardozo-Viviana.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” title_text=”Cardozo, Viviana” sticky_enabled=”0″]<\/p>\n

vcardozo@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

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On biopharmaceuticals, the focus of study of the laboratory, we have developed specific kits and analytical methodologies base on requests from productive sector. Some of the projects that we are working on are:<\/p>\n

\n Anti-TN antibody engineering in molecular imaging and cancer immunotherapy.<\/strong>\n <\/p>\n

Using different recombinant antibodies and fragments of them, we found that the Tn antigen is a molecular target of interest for the diagnosis and treatment of human tumours.<\/strong> We develop fragments of antibodies (scfv, minibodies and nanobodies) for their application in molecular imaging. We also investigated the development of immuno-nanoparticles to direct drugs towards tumours.<\/p>\n

\n O-glycosylation enzymes as predictive and predictive biomarkers in oncology.<\/strong>\n <\/p>\n

We evaluated whether the expression of GalNAc-Ts enzymes, which catalyse the first stage of O-glycosylation, can influence the biological properties of cancer cells<\/strong> (invasiveness, chemo-resistance, etc.), to subsequently develop useful diagnostic procedures in clinical oncology.<\/p>\n

\n Anti-tumour immunotherapy using parasite molecules.<\/strong>\n <\/p>\n

We found that some cancer-specific glyco-antigens are also expressed in certain parasites.<\/strong> We observed that immunization with extracts of Trypanosoma cruzi and Echinococcus granulosus induces anti-tumour immune responses in animal models. We seek to elucidate the molecular and cellular bases of this type of immune responses in order to generate a new type of anti-tumour therapeutic strategy.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-equipos” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Courses<\/h2>\n

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    \n
  • International course \u201cGlycobiology and Cancer: from Chemistry to Clinical applications\u201d.
    Nov 29\u2013Dec 7, 2013. Organisers: Eduardo Osinaga and Nora Berois.<\/li>\n
  • International course \u201cProgress in Molecular oncology and its clinical impact\u201d. May 2-6, 2016. Organisers: Eduardo Osinaga, Nora Berois and Mario Varangot.<\/li>\n
  • International course \u201cProgress in Molecular oncology and its clinical impact\u201d. Nov 27- Dec 1, 2017. Organisers: Eduardo Osinaga, Nora Berois, Luis Ubillos and Gabriel Krygier.<\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-servicios” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Patents<\/h2>\n

    [\/et_pb_text][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

      \n
    • Hubert-Haddad P, Amigorena S, Sastre-Garau X, Osinaga E, Pritsch O, Oppezzo P, Perez F, Moutel S. An antibody specific for the Tn antigen for the treatment of cancer.
      European Patent WO\/2009\/007222 (2009)<\/li>\n<\/ul>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-proyectos” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

      Projects<\/h2>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ module_class=”dfc-proyectos” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

      2023-2024 <\/strong>\u2013 \u201cDevelopment of a liquid biopsy procedure for assessment of response to immunotherapy in cancer\u201d. Funded by: Fondo Sectorial de Salud, ANII, Uruguay. Responsible: Eduardo Osinaga.<\/p>\n

      2022-2024 <\/strong>\u2013 \u201cApplication of genetic engineering to enhance the anti-tumour activity of a cancer-specific antibody\u201d. Funded by: Fondo Mar\u00eda Vi\u00f1as, ANII, Uruguay. Responsible: Eduardo Osinaga.<\/p>\n

      2018-2022 \u2013 <\/strong>\u201cCancer immunotherapy using parasite molecules\u201d. Funded by: Fondo Mar\u00eda Vi\u00f1as, ANII, Uruguay. Responsible: Eduardo Osinaga.<\/p>\n

      2018-2020<\/strong> \u2013 \u201cCancer immunotherapy using molecules of Trypanosoma cruzi\u201d. Funded by: ANII-GSK. Responsible: Eduardo Osinaga.<\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” custom_margin=”3px|||||” custom_padding=”0px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

      2016-2017<\/strong> \u2013 “Immune-nanoparticles in cancer treatment Project”.
      Responsibles: Eduardo Osinaga and Alvaro Mombr\u00fa.
      \u201cLinking qualified diaspora with intensive sectors in knowledge, technology and innovation of Uruguay\u201d. BID-MIEM Project. ATN\/KF-13883-UR<\/p>\n

      2015-2019<\/strong> \u2013 \u201cImmunity and cancer\u201d. Funded by: Programa Grupos de Investigaci\u00f3n, CSIC-UdelaR, Uruguay. Responsible: Eduardo Osinaga.<\/p>\n

      2015-2018<\/strong> \u2013 \u201cCancer molecular imaging with anti-Tn tumour antigen antibodies produced by genetic engineering\u201d. Responsible: Eduardo Osinaga. ANII I+I (co-funded by: De Larrobla y asociados).<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||26px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

      Main publications<\/h2>\n

      [\/et_pb_text][et_pb_accordion icon_color=”#005293″ _builder_version=”4.14.6″ _module_preset=”default” toggle_text_color=”#005293″ toggle_font=”Titillium Web|600|||||||” toggle_font_size=”17px” custom_margin=”||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_accordion_item title=”vacio” open=”on” _builder_version=”4.14.6″ _module_preset=”default” custom_css_main_element=”display:none” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_accordion_item][et_pb_accordion_item title=”2022″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

        \n
      • Berois N, Pittini A, Osinaga E. Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives. Cancers. 2022; 14(3):645. https:\/\/doi.org\/10.3390\/cancers14030645<\/li>\n<\/ul>\n

        [\/et_pb_accordion_item][et_pb_accordion_item title=”2020″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

          \n
        • Olano C, L\u00f3pez V, Freire T, Rodr\u00edguez X, Pontet Y, Alem\u00e1n A, Rodr\u00edguez N, Rovira L, Trucco E, Osinaga E, Cohen H, Quigley EM. Irritable bowel syndrome in celiac disease – relationships to celiac disease antibodies and levels of pro-inflammatory cytokines. Rev Gastroenterol Peru. 2020; 40:127-135<\/li>\n<\/ul>\n

          [\/et_pb_accordion_item][et_pb_accordion_item title=”2018″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

            \n
          • Ubillos L, Berriel E, Mazal D, Victoria S, Barrios E, Osinaga E, Berois N. Polypeptide-GalNAc-T6 expression predicts better overall survival in patients with colon cancer. Oncol Lett. 16:225-234 (2018).<\/li>\n<\/ul>\n

            [\/et_pb_accordion_item][et_pb_accordion_item title=”2017″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

              \n
            • Festari MF, Trajtenberg F, Berois N, Pantano S, Revoredo L, Kong Y, Solari-Saquieres P, Narimatsu Y, Freire T, Bay S, Robello C, B\u00e9nard J, Gerken TA, Clausen H, Osinaga E. Revisiting the human polypeptide GalNAc-T1 and T13 paralogs. Glycobiology 27:140-153 (2017).<\/li>\n
            • Berois N, Touya D, Ubillos L, Bertoni B, Osinaga E, Varangot M. Prevalence of EGFR mutations in lung cancer in Uruguayan population. Journal of Cancer Epidemiology ID 6170290 (2017).<\/li>\n
            • Nozar F, Greif D, Franciulli A, Barrios E, Osinaga E, Berois N. Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome. Medical Research Archives. Volume 5, issue 5. May (2017).<\/li>\n<\/ul>\n

              [\/et_pb_accordion_item][et_pb_accordion_item title=”2016″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                \n
              • Sedlik C, Heitzmann A, Viel S, Ait Sarkouh R, Batisse C, Schmidt F, De La Rochere P, Amzallag N, Osinaga E, Oppezzo P, Pritsch O, Sastre-Garau X, Hubert P, Amigorena S, Piaggio E. Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen. Oncoimmunology. 5:e1171434 (2016).<\/li>\n
              • Osinaga E, Freire T, Ubillos L. Author\u2019s reply to: Could cross-immunological reactivity to Trypanosoma cruzi antigens be considered a rational strategy for designing vaccines against cancer? Int J Cancer. 139:2144 (2016).<\/li>\n
              • Garc\u00eda E, Tiscornia I, Libisch G, Trajtenberg F, Bollati-Fogol\u00edn M, Rodr\u00edguez E, Noya V, Chiale C, Brossard N, Robello C, Santi\u00f1aque F, Folle G, Osinaga E and Freire T. MUC5B silencing reduces chemo-resistance of MCF-7 breast tumor cells and impairs maturation of dendritic cells. Int. J. Oncol. 48:2113-23 (2016).<\/li>\n
              • Ubillos L, Freire T, Berriel E, Chiribao ML, Chiale C, Festari MF, Medeiros A, Mazal D, Rond\u00e1n M, Bollati-Fogol\u00edn M, Rabinovich GA, Robello C and Osinaga E. Trypanosoma cruzi extracts elicits protective immune response against chemically-induced colon and mammary cancers. Int J Cancer 138:1719-31 (2016).<\/li>\n<\/ul>\n

                [\/et_pb_accordion_item][et_pb_accordion_item title=”2014″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                  \n
                • Ikemori R, Longo Machado C, Furuzawa K, Nonogaki S, Osinaga E, Umezawa K, Carvalho MA, Verinaud L and Chammas R. Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survival. Plos One 4;9(11):e111592 (2014).<\/li>\n
                • Berois N and Osinaga E. Glycobiology of neuroblastoma: Impact on tumor behavior, prognosis and therapeutic strategies. Frontiers in Oncology 4:114 (2014).<\/li>\n
                • Libisch G, Cas\u00e1s M, Chiribao ML, Moreno P, Cayota A, Osinaga E, Oppezzo P and Robello C. GalNAc-T11 as a potential new molecular marker in chronic lymphocytic leukemia. Gene 533:270-9 (2014).<\/li>\n
                • Berois N, Heard I, Fort Z, Alonso R, Sica A, Moerzinger P, Rodriguez G, Sancho-Garnier H, Osinaga E and Favre M. Prevalence of type-specific HPV infection in Uruguay. J. Med. Virol. 86:647-52 (2014).<\/li>\n<\/ul>\n

                  [\/et_pb_accordion_item][et_pb_accordion_item title=”2013″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                    \n
                  • Berriel E, Russo S, Monin L, Festari MF, Berois N, Fern\u00e1ndez G, Freire T and Osinaga E. Anti-tumor activity of human hydatid cyst fluid in a murine model of colon cancer. The Scientific World Journal 2013:230176 (2013).<\/li>\n
                  • Noya V, Bay S, Festari MF, Garc\u00eda E, Rodriguez E, Chiale C, Ganneau C, Baleux F, Astrada S, Bollati \u2013Fogol\u00edn M, Osinaga E and Freire T. Mucin-like peptides from Echinococcus granulosus induce antitumor activity. Int. J. Oncology 43:775-84 (2013).<\/li>\n
                  • Mazal D, Lo-Man R, Bay S, Pritsch O, D\u00e9riaud E, Ganneau C, Medeiros A, Ubillos L, Obal G, Berois N, Bollati-Fogolin M, Leclerc C and Osinaga E. Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer. Cancer Immunol. Immunother. 62:1107-22 (2013).<\/li>\n
                  • Berois N, De Cremoux P, Mazal D, Sica A, Cedeira M, Caserta B, Barrios E, Osinaga E and Sastre-Garau X. Prevalence and distribution of high-risk human papillomavirus genotypes in invasive carcinoma of the uterine cervix in Uruguay. Int. J. Gynecol. Cancer 23:527-532 (2013).<\/li>\n
                  • Dalotto-Moreno T, Croci DO, Cerliani JP, Martinez-Allo VC, Dergan-Dylon S, Mendez Huergo SP, Stupirski JC, Mazal D, Osinaga E, Toscano MA, Sundblad V, Rabinovich GA, Salatino M. Targeting galectin-1 overcomes breast cancer associated immunosuppression and prevents metastatic disease. Cancer Res. 73:1107-17 (2013).<\/li>\n
                  • Berois N, Gattolliat C-H, Barrios E, Capandeguy L, Douc-Rasy S, Valteau-Couanet D, B\u00e9nard J and Osinaga, E. GALNT9 gene expression is a prognostic marker in neuroblastoma patients. Clinical Chemistry 59:225-233 (2013).<\/li>\n
                  • Medeiros A, Berois N, Incerti M, Bay S, Franco Fraguas L and Osinaga E. A Tn antigen binding lectin from Myrsine coriacea displays toxicity on human cancer cell lines. J Natural Med 67:247-54 (2013).<\/li>\n<\/ul>\n

                    [\/et_pb_accordion_item][et_pb_accordion_item title=”2012″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                      \n
                    • Freire T and Osinaga E. The sweet-side of cancer immunotherapy. Immunotherapy; 4:719-34 (2012).<\/li>\n
                    • Chiribao M, Libisch G, Osinaga E, Parodi A and Robello C. Cloning, localization and differential expression of the Trypanosoma cruzi TcOGNT-2 glycosyltransferase gene. Gene 498:147-54 (2012).<\/li>\n<\/ul>\n

                      [\/et_pb_accordion_item][et_pb_accordion_item title=”2011″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                        \n
                      • Hubert P, Heitzmann A, Viel S, Nicolas A, Sastre-Garau X, Oppezzo P, Pritsch O, Osinaga E and Amigorena S. Antibody-dependent cell cytotoxicity synapses form in mice during tumor-specific antibody immunotherapy. Cancer Research 71:5134-43 (2011).<\/li>\n<\/ul>\n

                        [\/et_pb_accordion_item][et_pb_accordion_item title=”2010″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                          \n
                        • Hill M, Mazal D, Biron V, Pereira L, Ubillos L, Berriel E, Ahmed H, Freire T, Rond\u00e1n M, Vasta GR, Liu FT, Iglesias MM and Osinaga E. A novel clinically-relevant animal model to study galectin-3 and its ligands during colon carcinogenesis. J. Histochem. Cytochem. 58:553-65 (2010).<\/li>\n
                        • Robles A, Medeiros A, Berois N, Balter H, Pauwels E and Osinaga E. In site interaction evaluation of Tn density by inhibition\/competition assays. Nuclear Medicine and Biology 37:453-8 (2010).<\/li>\n<\/ul>\n

                          [\/et_pb_accordion_item][et_pb_accordion_item title=”2009″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                            \n
                          • Gomes J, Marcos NT, Berois N, Osinaga E, Magalh\u00e3es A, Pinto-de-Sousa J, Almeida R, G\u00e4rtner F and Reis CA. Expression of UDP-N-acetyl-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. J. Histochem. Cytochem. 57:79-86 (2009).<\/li>\n<\/ul>\n

                            [\/et_pb_accordion_item][et_pb_accordion_item title=”2008″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                              \n
                            • Croci D, Cognoa I, Rumie Vittara N, Salvatierra E, Trajtenberg F, Podhajcer O, Osinaga E, Rabinovich G and Rivarola V. Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway. J. Cell. Biochem. 105:381-90 (2008).<\/li>\n
                            • Medeiros A, Chiribao ML, Ubillos L, Festari MF, Salda\u00f1a J, Robello C, Dom\u00ednguez L, Calvete JJ and Osinaga E. Mucin-type O-glycosylation in Mesocestoides vogae (syn. corti). Int. J. Parasitology 38:265-76 (2008).<\/li>\n<\/ul>\n

                              [\/et_pb_accordion_item][et_pb_accordion_item title=”2007″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                                \n
                              • Osinaga E. Expression of cancer-associated simple mucin-type O-glycosylated antigens in parasites. Critical review. IUBMB Life 59:269-73 (2007).<\/li>\n<\/ul>\n

                                [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

                                Glycobiology and Tumor ImmunologyProteins and carbohydrates (sugars) interaction plays an essential role in several cellular processes, such as cell proliferation and differentiation, as well as in different diseases, including viruses, bacteria and parasites infections. To perform these specialized functions, some types of carbohydrates bind to proteins creating complex structures called glycoproteins, which are found on […]<\/p>\n","protected":false},"author":8,"featured_media":1999,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[50],"tags":[],"dipi_cpt_category":[],"class_list":["post-4730","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-previous-laboratories"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=4730"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4730\/revisions"}],"predecessor-version":[{"id":24845564,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4730\/revisions\/24845564"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media\/1999"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=4730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/categories?post=4730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/tags?post=4730"},{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=4730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}