{"id":4750,"date":"2022-03-16T19:27:04","date_gmt":"2022-03-16T19:27:04","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/chronic-lymphoid-leukemia-research\/"},"modified":"2026-04-07T11:11:17","modified_gmt":"2026-04-07T14:11:17","slug":"chronic-lymphoid-leukemia-research","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/laboratories\/chronic-lymphoid-leukemia-research\/","title":{"rendered":"Chronic Lymphoid Leukemia Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”9px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_margin=”|auto|0px|auto|false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Titillium Web|700|||||||” header_font=”Titillium Web|700|||||||” header_text_color=”#005293″ header_font_size=”44px” custom_margin=”||22px|||” header_font_size_tablet=”38px” header_font_size_phone=”29px” header_font_size_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

\n Chronic Lymphoid Leukemia Research<\/span>
\n <\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Our laboratory focuses on the study of the mechanisms involved in the origins and progression of Chronic Lymphoid Leukemia (CLL), the most common type of leukemia in people over 50 years, whose incidence in Uruguay is 5 cases per 100,000 people. CLL originates in cells of the immune system known as B lymphocytes, which lose their ability to die and begin to accumulate in the blood. Although many patients with CLL respond to current treatments, some don\u2019t.<\/p>\n

<\/p>\n

The B lymphocyte is one of the most specialized cells of the immune system and is able to re-edit its DNA, thanks to the action of the cytidine deaminase (AID), an enzyme necessary to respond in the presence of different infections.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

However, the mutagenic action of the AID enzyme also has its negative aspects since B lymphocytes are continually exposed to damage of their DNA. Although the control mechanisms on AID are many and redundant, they sometimes fail, and in their absence this enzyme can be overexpressed in tumour cells, causing cancer progression and \/ or refractoriness in its treatment.<\/p>\n

<\/p>\n

Our advances are related to the characterization of the expression of the AID enzyme in patients with CLL, and the development of animal models to study the causes of the progression of the disease and the refractoriness in the treatment.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px|0px|false|false” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_5,1_5,1_5,1_5,1_5″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Members” button_alignment=”center” module_class=”df-button dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Research lines” button_alignment=”center” module_class=”df-button dfc-investigacion” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;||letter-spacing: -0.5px;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Courses” button_alignment=”center” module_class=”df-button dfc-cursos” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Projects” button_alignment=”center” module_class=”df-button dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Main publications” button_alignment=”center” module_class=”df-button dfc-publicaciones” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Pablo Oppezzo, PhD” position=”Head ” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Oppezzo-Pablo.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/pablo-oppezzo\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

poppezzo@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Florencia Palacios, PhD” position=”Senior associate researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Palacios-Florencia.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

palacios@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Rita Ur\u00eda, MD” position=”Research assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Uria-Rita.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

uria@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Gimena Dos Santos, MD, MSc” position=”Doctoral student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Dos-Santos-Gimena.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Medicine, Udelar
gdsantos@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.27.4″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Santiago Rodr\u00edguez, MSc” position=”Doctoral student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/02\/santiago-rodriguez-1.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Doctoral student
srodriguez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Juliana Querol, Eng” position=”Doctoral student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Querol-Juliana.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

jquerol@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Eugenia Payque, Eng” position=”Technical assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Payque-Eugenia.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

epayque@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Jorge Souto, BSc” position=”Master's degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/09\/Souto-Jorge-02.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

jsouto@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.27.4″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Mercedes Chifteain” position=”Undergraduate student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Chifteian-Mercedes-ajustada.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mchifteain@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Sof\u00eda Rocha” position=”Intern” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Rocha-Sofia-ajustada.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

srocha@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Camila Grille” position=”Undergraduate student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Grille-Camila.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

<\/a>cgrille@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Marianela Lasagna, MD, PhD” position=”Posdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/03\/Lasagna-Marianela.jpg” _builder_version=”4.27.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” title_text=”Lasagna, Marianela” sticky_enabled=”0″]<\/p>\n

mlasagna@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Characterization of the origins of the immunological microenvironment in tumour progression and its correlation with the constitutive expression of AID in progressive patients with CLL. <\/strong>The objective is to corroborate if the constitutive expression of the enzyme cytidine deaminase (AID) during the evolution of the disease is a key event in the progression of CLL.<\/p>\n

<\/p>\n

Deciphering of the effect of new inhibitors of kinases and proapoptotic molecules on the proliferative subpopulations of CLL. <\/strong>It aims to characterize the molecular and phenotypic effects of new kinase inhibitors and the action of proapoptotic molecules in proliferating subpopulations of the tumour clone during treatment.<\/p>\n

<\/p>\n

The S100A9 protein as a new therapeutic target in CLL. Linkage of inflammation, microenvironment and clinical evolution. <\/strong>We aim to deepen the knowledge of the role of inflammation in the clinical evolution of patients with CLL.<\/p>\n

<\/p>\n

Development of an artificial binding protein (ABP) platform to generate new prognostic and treatment tools in the LLC. <\/strong>The objective is to create a therapeutic tool (ABP) capable of simultaneously recognizing the tumor cell and recruiting natural killer cells (NK) to destroy the tumor clone.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-cursos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Courses<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    \n
  • First Iberoamerican meeting on Chronic Lymphocytic Leukemia. Date and place: 15-17 November 2013, Montevideo, Uruguay.<\/li>\n
  • First LatinAmerican Workshop on prognosis markers in CLL: \u201cFluorescence in situ hibridization (FISH) as prognosis marker in CLL\u201d. Date and place: 26-29 May 2014, Buenos Aires, Argentina.<\/li>\n
  • Second LatinAmerican Workshop on prognosis markers in CLL: \u201cCytometry approaches in the prognosis of CLL\u201d. Date and place: 16-18 November 2014, Florianopolis, Brazil.<\/li>\n
  • Third LatinAmerican Workshop on prognosis markers in CLL: \u201cAnalysis of mutational profile of immunoglobulin VH genes in CLL\u201c. Date and place: 20-22 May 2015, Montevideo, Uruguya. Participants: 42.<\/li>\n
  • Academia de Hematolog\u00eda. Training course organized by AbbVie, Institut Pasteur de Montevideo and Hospital Maciel for AbbVie Staff. Three in the year 2016-2017.<\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Projects<\/h2>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2021-2023 <\/strong>\u2013 “Functional characterization of AID off-target mutations during leukemia progression”. ANII Grant FCE_2021. Responsible: Pablo Oppezzo.<\/p>\n

    <\/p>\n

    2020-2022<\/strong> \u2013 “Musashi 2 RNA-Binding Protein as a novel therapeutic target for chronic lymphocytic leukemia patients”. ANII\/GSK call (FSGSK_1_2020_1_165303). Responsible: Florencia Palacios. Co-responsible: Pablo Oppezzo.<\/p>\n

    <\/p>\n

    2018-2021<\/strong> \u2013 Evaluaci\u00f3n de cambios gen\u00f3nicos asociados con la enzima AID y su papel en la progresi\u00f3n tumoral de neoplasias de c\u00e9lulas B. Researchers: M.A. Navarrete y P. Oppezzo. Fondecyt N\u00b0 1180882.<\/p>\n

    <\/p>\n

    2018-2020<\/strong> \u2013 S100A9 as a novel target in CLL. Linking inflammation, microenvironment and clinical evolution. ANII-GSK Project.<\/p>\n

    <\/p>\n

    2015-2018 <\/strong>\u2013 Development of Union Proteins (Afitins) for the evaluation of new prognosis and therapy techniques in Chronic Lymphoid Leukemia. Fondo Mar\u00eda Vi\u00f1as: FMV_1_2014_1_104397<\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”3px|||||” custom_padding=”0px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2015-2017<\/strong> \u2013 “Anomalous expression of Lipoprotein Lipase in Chronic Lymphocytic Leukemia: Towards the development of a new prognostic marker”. ANII Grant FMV_2015. Responsible: Pablo Oppezzo.<\/p>\n

    <\/p>\n

    2012-2015<\/strong> \u2013 Expression of Lipoprotein Lipase in B cells of Chronic Lymphoid Leukemia (CLL): Towards the development of a new prognostic marker. Fondo Mar\u00eda Vi\u00f1as: FMV_2_2011_1_7323<\/p>\n

    <\/p>\n

    2012-2015<\/strong> \u2013 Implications of the abnormal expression of the mutagenic AID enzyme in leukemic processes: Development of a tumor model. Fondo Clemente Estable: FCE_2011_7273<\/p>\n

    <\/p>\n

    2011-2014 \u2013 <\/strong>Thematic networks \u2013 Dr. Pablo Oppezzo \u2013 \u201cIberoamerican network on Chronic Lymphocytic Leukemia: towards the development of new prognostic markers\u201d. CYTED.<\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||26px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Main publications<\/h2>\n

    [\/et_pb_text][et_pb_accordion icon_color=”#005293″ _builder_version=”4.16″ _module_preset=”default” toggle_text_color=”#005293″ toggle_font=”Titillium Web|600|||||||” toggle_font_size=”17px” custom_margin=”||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_accordion_item title=”vacio” open=”on” _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display:none” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_accordion_item][et_pb_accordion_item title=”2021″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

      \n
    • Morande PE, Yan XJ, Sepulveda-Yanez JH, Seija N, Marquez ME, Sotelo NS, Abreu C, Crispo M, Fern\u00e1ndez-Gra\u00f1a G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P*. AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms. Blood. 2021 Mar 2:blood.2020008654.<\/li>\n<\/ul>\n

      [\/et_pb_accordion_item][et_pb_accordion_item title=”2019″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

        \n
      • Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia.Morande PE, Sivina M, Uriepero A, Seija N, Berca C, Fresia P, Landoni AI, Di Noia JM, Burger JA, Oppezzo P. Blood. 2019 May 9;133(19):2056-2068. doi: 10.1182\/blood-2018-09-876292.<\/li>\n<\/ul>\n

        [\/et_pb_accordion_item][et_pb_accordion_item title=”2018″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

          \n
        • Multi-Compartment and Multi-Host Vector Suite for Recombinant Protein Expression and Purification. Ortega C, Prieto D, Abreu C, Oppezzo P, Correa A. Front Microbiol. 2018 Jun 27;9:1384. doi: 10.3389\/fmicb.2018.01384. eCollection 2018.<\/li>\n
        • LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL. Prieto D, Seija N, Uriepero A, Souto-Padron T, Oliver C, Irigoin V, Guillermo C, Navarrete MA, In\u00e9s Landoni A, Dighiero G, Gabus R, Giordano M, Oppezzo P. Br J Haematol. 2018 Aug;182(4):521-525. doi: 10.1111\/bjh.15427. Epub 2018 Jun 28.<\/li>\n<\/ul>\n

          [\/et_pb_accordion_item][et_pb_accordion_item title=”2017″ _builder_version=”4.16″ _module_preset=”default” link_option_url_new_window=”on” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

            \n
          • S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-\u03baB activity during disease progression. Prieto D, Sotelo N, Seija N, Sernbo S, Abreu C, Dur\u00e1n R, Gil M, Sicco E, Irigoin V, Oliver C, Landoni AI, Gabus R, Dighiero G, Oppezzo P. Blood. 2017, Aug 10;130(6):777-788. doi: 10.1182\/blood-2017-02-769851.<\/li>\n
          • Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination. Almej\u00fan MB, Campos BC, Pati\u00f1o V, Galicchio M, Zelazko M, Oleastro M, Oppezzo P, Danielian S. J Allergy Clin Immunol. 2017, Mar;139(3):913-922. doi: 10.1016\/j.jaci.2016.08.030.<\/li>\n<\/ul>\n

            [\/et_pb_accordion_item][et_pb_accordion_item title=”2015″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

              \n
            • Activation of the PI3K\/AKT pathway by microRNA-22 results in CLL B-cell proliferation. Palacios F, Abreu C, Prieto D, Morande P, Ruiz S, Fern\u00e1ndez-Calero T, Naya H, Libisch G, Robello C, Landoni AI, Gabus R, Dighiero G, Oppezzo P. Leukemia. 2015, Jan;29(1):115-25. doi: 10.1038\/leu.2014.158.<\/li>\n<\/ul>\n

              [\/et_pb_accordion_item][et_pb_accordion_item title=”2013″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                \n
              • \u00abRole of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia\u00bb. Oppezzo P, Dighiero G. Blood Cancer J. 2013, Sep 20;3:e149. doi: 10.1038\/bcj.2013.45.<\/li>\n
              • Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment. Moreno P, Abreu C, Borge M, Palacios F, Morande P, Pegazzano M, Bianchi S, Landoni AI, Agrelo R, Giordano M, Dighiero G, Gamberale R, Oppezzo P. Leukemia. 2013, Mar;27(3):721-5. doi: 10.1038\/leu.2012.212.<\/li>\n<\/ul>\n

                [\/et_pb_accordion_item][et_pb_accordion_item title=”2010″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                  \n
                • High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Palacios F, Moreno P, Morande P, Abreu C, Correa A, Porro V, Landoni AI, Gabus R, Giordano M, Dighiero G, Pritsch O, Oppezzo P. Blood. 2010, Jun 3;115(22):4488-96. doi: 10.1182\/blood-2009-12-257758.<\/li>\n<\/ul>\n

                  [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

                  Chronic Lymphoid Leukemia Research Our laboratory focuses on the study of the mechanisms involved in the origins and progression of Chronic Lymphoid Leukemia (CLL), the most common type of leukemia in people over 50 years, whose incidence in Uruguay is 5 cases per 100,000 people. CLL originates in cells of the immune system known as […]<\/p>\n","protected":false},"author":8,"featured_media":2294,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[48],"tags":[],"dipi_cpt_category":[],"class_list":["post-4750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-laboratories"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=4750"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4750\/revisions"}],"predecessor-version":[{"id":24854560,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4750\/revisions\/24854560"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media\/2294"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=4750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/categories?post=4750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/tags?post=4750"},{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=4750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}