{"id":4774,"date":"2022-03-17T17:39:23","date_gmt":"2022-03-17T17:39:23","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/microbial-genomics\/"},"modified":"2026-04-10T13:54:23","modified_gmt":"2026-04-10T16:54:23","slug":"microbial-genomics","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/g4-labs\/microbial-genomics\/","title":{"rendered":"Microbial Genomics"},"content":{"rendered":"

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Microbial Genomics<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

The Microbial Genomics Laboratory is focused on the study of the microbial world (mainly bacteria), given the relevance of microorganisms for both human and livestock health. To achieve this we use genomics, metagenomics, bioinformatics and bacteriology as fundamental tools. The information we generate help us to understand the underlying evolutionary mechanisms that shape the acquisition of antibiotic resistance, host adaptation and transmission between hosts and the environment. Accordingly, our work contributes to generate new diagnostic approaches for infectious disease, to understand epidemiological patterns of bacterial infections and to identify biomarkers in microbial communities associated to several diseases.<\/p>\n

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Finances:<\/p>\n

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Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.27.4″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Nadia Riera, PhD” position=”Senior Associate Researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/01\/Nadia-Riera.png” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

nriera@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Andr\u00e9s Parada, PhD” position=”Research assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Parada-Andres.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Facultad de Ciencias, Udelar<\/p>\n

<\/a>Posdoc
andrespara@pasteur.edu.uy<\/a><\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Cecilia Salazar, PhD” position=”Postdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Salazar-Cecilia.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

csalazar@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Florencia Pe\u00f1alba, Ing” position=”Estudiante de maestr\u00eda” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Penalba-Florencia.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

fpenalba@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Mat\u00edas Gim\u00e9nez, MSc” position=”PhD student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Gimenez-Matias.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mgimenez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Daniela Costa-Duarte, PhD” position=”Postdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Costa-Daniela.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” custom_padding=”0px|||||” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

dcosta@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Josefina Vera, Ing” position=”Estudiante de maestr\u00eda” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/03\/josefina-vera-1.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

jvera@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Valentina Perdomo” position=”Undergraduate intern” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/03\/Valentina-Perdomo.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

vperdomo@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.27.4″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Maite Irastorza, Ing” position=”Undergraduate intern” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/03\/Maite.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mirastorza@pasteur.edu.uy<\/a><\/p>\n

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jmartinez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Catalina Vaz” position=”Pasante honoraria” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/icono-persona.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” title_text=”icono-persona” sticky_enabled=”0″]<\/p>\n

cvaz@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Tom\u00e1s Tejera, BSc” position=”Estudiante de maestr\u00eda” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/icono-persona.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” title_text=”icono-persona” sticky_enabled=”0″]<\/p>\n

ttejera@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.27.4″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Luc\u00eda Bonanni” position=”Pasante” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/icono-persona.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” title_text=”icono-persona” sticky_enabled=”0″]<\/p>\n

lbonanni@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.27.4″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

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Estudio del microbioma humano en contexto de salud y enfermedad. Estudiamos el rol de los microorganismos y biomarcadores microbianos asociados a diferentes contextos de salud\/enfermedad.<\/p>\n

Microbioma intestinal como reservorio de nuevos compuestos antibi\u00f3ticos. Estudio de nuevos compuestos y prote\u00ednas antibi\u00f3ticas identificadas de microorganismos intestinales con actividad antimicrobiana contra bacterias multidrogoresistentes ESKAPE.<\/p>\n

Estudio del microbioma intestinal animal y su rol en la salud.<\/p>\n

Microbioma ambiental y el impacto del uso de suelos.<\/p>\n

Poblaciones microbianas relevantes en la salud intestinal de la poblaci\u00f3n uruguaya.<\/p>\n

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Projects<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

2024-actual<\/strong> \u201cDime con qui\u00e9n andas y te dir\u00e9 c\u00f3mo eres: influencia de la microbiota en la patogenicidad de Blastocystis spp. y su efecto sobre el epitelio intestinal humano\u201d. Transversal. Responsable: Romina Pagotto, Co-responsable: Nadia Riera.<\/p>\n

2024-actual <\/strong>\u201cCaracterizaci\u00f3n gen\u00f3mica poblacional y fenot\u00edpica de Catenibacterium\u201d Fondo Clemente Estable, Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n (ANII). Responsable: Mat\u00edas Gim\u00e9nez. Co-responsable: Daniela Costa.<\/p>\n

2023-actual<\/strong> \u201cCaracterizaci\u00f3n del microbioma intestinal y en el trastorno del espectro autista
en Uruguay\u201d. Despegue cient\u00edfico, PEDECIBA. Responsable: Nadia Riera.<\/p>\n

2023-actual<\/strong> \u201cIdentificaci\u00f3n y validaci\u00f3n de nuevos biomarcadores de salud intestinal para el
diagn\u00f3stico temprano de autismo\u201d. Fondo Sectorial de Salud, Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n (ANII). Responsable: Nadia Riera.<\/p>\n

2019-2024 <\/strong>\u201cRol de la microbiota intestinal en la respuesta a la inmunoterapia del c\u00e1ncer en Uruguay\u201d Fondo ANII-GSK. Responsable: Nadia Riera.<\/strong><\/p>\n

2019-actual<\/strong> \u2013 \u201cLatinbiota: comprendiendo la evoluci\u00f3n, transmisi\u00f3n y resistencia a antibi\u00f3ticos de pat\u00f3genos asociados a la microbiota en pa\u00edses de Latinoam\u00e9rica\u201d. Responsable: Gregorio Iraola.
Wellcome Sanger Institute.<\/p>\n

2017-actual<\/strong> \u2013 \u201cEpidemiolog\u00eda gen\u00f3mica de infecciones por Clostridium difficile en Latinoam\u00e9rica\u201d. Responsable: Gregorio Iraola. Wellcome Sanger Institute.<\/p>\n

2017-actual<\/strong> \u2013 \u201cCentro de Metagen\u00f3mica: una plataforma para la incubaci\u00f3n de proyectos aplicados al monitoreo de ambientes prioritarios\u201d. Responsables: Gast\u00f3n Gonnet, Gregorio Iraola.
ANII.<\/p>\n

2017-actual<\/strong> \u2013 \u201cDiversidad global, epidemiolog\u00eda gen\u00f3mica y evoluci\u00f3n de Leptospira spp.\u201d. Responsable: Mathieu Picardeau. RIIP-PTR.<\/p>\n

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2017-2019<\/strong> \u2013 \u201cCharacterization of genotype-phenotype associations in Campylobacter fetus strains causing systemic infections in humans”. Responsible: Gregorio Iraola. DC2C-FVF.<\/p>\n

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2016-2019<\/strong> \u2013 \u201cDevelopment and validation of methodologies for the diagnosis and control of bovine genital campylobacteriosis\u201d. Responsibles: Luc\u00eda Calleros, Gregorio Iraola. ANII-FSSA.<\/p>\n

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2016-2019<\/strong> \u2013 \u201cGenomic evolution of Mycobacterium avium subsp. paratuberculosis in
wild and farm animals”. Responsible: Pablo Fresia. ANII-FCE.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||26px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Main publications<\/h2>\n

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Riera N, Salazar C, Rivera B, Galiana A, Dur\u00e1n R, Portela MM, Antelo V, Pi B, Gonz\u00e1lez O,
Iraola G, Genetically divergent Francisella philomiragia associated with septic arthritis,
Montevideo, Uruguay, New Microbes and New Infections, Volume 57, 2024, 101210, ISSN
2052-2975, https:\/\/doi.org\/10.1016\/j.nmni.2023.101210.<\/a><\/p>\n

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