{"id":4778,"date":"2022-03-17T17:54:23","date_gmt":"2022-03-17T17:54:23","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/apicomplexan-biology\/"},"modified":"2026-04-10T13:56:08","modified_gmt":"2026-04-10T16:56:08","slug":"apicomplexan-biology","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/g4-labs\/apicomplexan-biology\/","title":{"rendered":"Apicomplexan Biology"},"content":{"rendered":"

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Apicomplexan Biology<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

We focus on the study of a group of parasites, causative agents of both human and veterinary disease, collectively known as Apicomplexa. We aim to unravel the molecular mechanisms underlying these parasites\u2019s ability to multipy and disseminate. With this, we aim to identify novel drug targets and drugs, to prevent these processes and more rapidly and effectively alleviate the diseases they cause.<\/p>\n

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Many, but not all, apicomplexans are able to cross the placental barrier causing abortion or congenital disease. We are interested in understanding the molecular basis of this capacitiy to cross such barrier, and their interactions with the host. Moreover, we are interested in understanding which specific strains of apicomplexans are present in our country,<\/p>\n

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and to which extent, in order to optimize treatments and diagnostics to what is locally relevant. Finally, we work in collaboration with the Parasitology and Micology department of the School of Medicine<\/p>\n

<\/p>\n

to provide molecular unequivocal diagnosis of parasitic diseases. This allows us to carry out epidemiological surveys, and to better and more effectively treat individual patients.<\/p>\n

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Finances:<\/p>\n

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custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Mar\u00eda Eugenia Francia, PhD” position=”Head ” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/01\/Francia-Maria-Eugenia.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/en\/heads-of-labs-and-units\/maria-eugenia-francia\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Medicine, Udelar
mfrancia@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Paula Faral-Tello, PhD” position=”Postdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Faral-Paula.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

pfaral@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Florencia Sena, PhD” position=”Postdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Horjales-Sofia.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Agronomy, Udelar
fsena@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Luisa Bern\u00e1, PhD” position=”Associate researcher” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Berna-Luisa.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Science, Udelar
lberna@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Sof\u00eda Horjales, PhD” position=”Postdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Horjales-Sofi\u0301a.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

shorjales@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Leandro Tana, MSc” position=”Research assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Tana-Leandro.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Doctoral student
ltana@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Mar\u00eda Alejandra Valent\u00edn” position=”Technical assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Valenti\u0301n-Alejandra.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” custom_css_member_description=”letter-spacing: -0.5px !important;” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Medicine, Udelar
avalentin@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Florencia Ricciuto” position=”Degree thesis student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/Ricciuto-Florencia.jpg” _builder_version=”4.16″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

fricciuto@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Eliana Tejera” position=”Honorary intern” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/02\/icono-persona.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

etejera@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Josefina Bonomi” position=”Honorary intern” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/08\/Josefina-Bonomi.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

jbonomi@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Danilo Solano” position=”PhD student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/09\/Danilo-Solano-1.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

dsolano@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Denisse Bercovici” position=”Undergraduate intern” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2025\/09\/Bercovici-Denisse.jpg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

dbercovici@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Luc\u00eda Anza” position=”PhD student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Anza-Lucia.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” title_text=”Anza, Luc\u00eda” sticky_enabled=”0″]<\/p>\n

luanza@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Joaqu\u00edn Rodr\u00edguez” position=”Degree thesis student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2026\/02\/Rodriguez-Joaquin.jpg” _builder_version=”4.27.5″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

jrodriguez@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Systematic identification<\/strong> of proteins with a role in regulating T. gondii\u2019s cell division.<\/p>\n

<\/p>\n

Identification of novel centrosomal components<\/strong> in T. gondii.<\/p>\n

<\/p>\n

Identification of the molecular mechanisms of vertical transmission of apicomplexan parasites<\/strong>.<\/p>\n

<\/p>\n

Study of mitochondrial genome variability in apicomplexan parasites<\/strong>.<\/p>\n

<\/p>\n

Determination of the mechanisms of sexed differentiation of Toxoplasma gondii<\/strong>.<\/p>\n

<\/p>\n

Molecular epidemiology of circulating T. gondii strains<\/strong> in humans and productive animals.<\/p>\n

<\/p>\n

Development of biotechnological products for the diagnosis and prevention of toxoplasmosis<\/strong> in production animals.<\/p>\n

<\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-cursos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Courses<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    \n
  • \u201cGenetic Manipulation in Unicelular Parasites\u201d. March 2017.
    Organized by M. Francia.<\/li>\n
  • \u201cMolecular Diagnosis of Parasitic Diseases\u201d. Second semester 2019.
    Department of Parasitology and Mycology. Faculty of Medicine (Udelar).<\/li>\n
  • International course: \u00a8Latin American Biology of Parasitism: LatAm BoP 2022\u00a8.<\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Projects<\/h2>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ module_class=”dfc-proyectos” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2017-2020<\/strong> \u2013 Functional characterization of the apicomplexan parasite centrosome.
    Responsible: Mar\u00eda E. Francia. FCE-ANII<\/p>\n

    <\/p>\n

    2017-2019<\/strong> \u2013 Molecular and functional characterization of new national and regional isolates of Neospora caninum. Exploitation of its distinctive features in the rational design of diagnostic tools and prophylaxis to combat bovine Neosporosis.
    Responsible: Mar\u00eda E. Francia. PDN-ANII<\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”3px|||||” custom_padding=”0px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    2018-2020<\/strong> \u2013 Systematic identification and functional analysis of novel centrosomal components in Toxoplasma gondii. Responsible: Maria E. Francia. ACIP-RIIP<\/p>\n

    <\/p>\n

    2019-2022<\/strong> \u2013 Quantification of embryonic and fetal losses in flocks of Uruguay and diagnosis of infectious agents involved. Responsible: Sergio Ferro (SUL). FCE-ANII<\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.16″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||26px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Main publications<\/h2>\n

    [\/et_pb_text][et_pb_accordion icon_color=”#005293″ _builder_version=”4.16″ _module_preset=”default” toggle_text_color=”#005293″ toggle_font=”Titillium Web|600|||||||” toggle_font_size=”17px” custom_margin=”||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_accordion_item title=”vacio” open=”on” _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display:none” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_accordion_item][et_pb_accordion_item title=”2023″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

      \n
    • Faral-Tello P, Pagotto R, Bollati-Fogol\u00edn M and Francia ME* (2023) Modeling the human placental barrier to understand Toxoplasma gondii\u00b4s vertical transmission. Front. Cell. Infect. Microbiol. 13:1130901. doi: 10.3389\/fcimb.2023.1130901<\/li>\n
    • Horjales S, Li Calzi M, Francia ME, Cayota A and Garcia-Silva MR* (2023) piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids. Front. Genet. 14:1129194. doi: 10.3389\/fgene.2023.1129194<\/li>\n<\/ul>\n

      [\/et_pb_accordion_item][et_pb_accordion_item title=”2022″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

        \n
      • Tomasina R, Gonzalez C. F., Martins-Duarte \u00c9. S., Bastin P, Gissot M, Francia ME* (2022). Separate to operate: the centriole-free inner core of the centrosome regulates the assembly of the intranuclear spindle in Toxoplasma gondii. MBio. e01859-22. doi:10.1128\/mbio.01859-22.<\/li>\n
      • Giannitti F*, Ar\u00e1oz V, da Silva Silveira C, Francia ME, Robello C and Cabrera A (2022) A holstein heifer infected with Neospora caninum NcUru3 congenitally transmits this strain to a viable offspring although infection does not protect her from aborting by a different N. caninum genotype in the subsequent gestation. Front. Vet. Sci. 9:889157. doi: 10.3389\/fvets.2022.889157<\/li>\n
      • Edreira MM*, Francia ME*, de Miguel N*. (2022) Editorial: Host\/Parasite Molecular and Cellular Interactions in the Establishment and Maintenance of Protozoan Infections. Front. Cell. Infect. Microbiol., 24 May 2022. doi.org\/10.3389\/fcimb.2022.930073. *equal contribution<\/li>\n
      • Dorsch M, Francia ME, Tana LR, Gonz\u00e1lez FC, Cabrera A, Calleros L, Sanguinetti M, Barcellos M, Zarantonelli M, Ciuffo C, Maya L, Castells M, Mirazo S, Da Silva Silveira C, Rabaza A, Caffarena R, D\u00edaz BD, Ar\u00e1oz V, Matto C, Armendano JI, Salada S, Fraga M, Fierro S and Giannitti F. (2022) Diagnostic investigation of 100 cases of abortion in sheep in Uruguay: 2015-2021. Front. Vet. Sci., 19 May 2022. doi.org\/10.3389\/fvets.2022.904786<\/li>\n<\/ul>\n

        [\/et_pb_accordion_item][et_pb_accordion_item title=”2021″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

          \n
        • Berna L, Rego N, Francia ME. The elusive mitochondrial genomes of Apicomplexa: where are we now? (2021). Front. Microbiol. | doi: 10.3389\/fmicb.2021.751775<\/li>\n
        • Mannise, N., Cabrera, A., Juan, H. Cosse, M., Giannitti, F., Francia, ME., Gonza\u0301lez, T., Iriarte, A., Riet-Correa, F., Robello, C., Gonza\u0301lez, S. (2021). Molecular detection of coccidian Apicomplexa Parasites isolated from wild crab-eating and pampas foxes through novel TaqMan\u2122 probes: a contribution to their molecular epidemiology. Mol Biol Rep. doi.org\/10.1007\/s11033-021-06492-w<\/li>\n
        • Gissot M, Pawlowic MC, Modrzynska KK and Francia ME. (2021) Editorial: Molecular Basis of Stage Conversion in Apicomplexan Parasites. Front. Cell. Infect. Microbiol. 11:680184. doi: 10.3389\/fcimb.2021.680184. In Press<\/li>\n
        • Berna L, Marquez P, Cabrera A, Greif G, Francia ME*, Robello C*. (2021) Reevaluation of two Apicomplexans genomes reveals misassembly, karyotype differences and lack of synteny. Genome Research. doi: 10.1101\/gr.262832.120. In Press.<\/li>\n<\/ul>\n

          [\/et_pb_accordion_item][et_pb_accordion_item title=”2020″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

            \n
          • Tomasina R & Francia ME*. The structural and molecular underpinnings of gametogenesis in Toxoplasma gondii (2020). Front. Cell. Infect. Microbiol. 10:608291. doi: 10.3389\/fcimb.2020.6082913.<\/li>\n
          • Francia ME*, Ting LM, Crocken M, Kim K, Dubremetz JF, Striepen B*. A homolog of Structural Maintenance of Chromosome 1 is a persistent centromeric protein which associates with nuclear pore components in Toxoplasma gondii. (2020). Front. Cell. Infect. Microbiol. 10:295. doi: 10.3389\/fcimb.2020.00295 *co-corresponding authors<\/li>\n
          • Maci\u0301as-Rioseco M, Silveira C, Fraga M, Casaux L, Cabrera A, Francia ME, et. al. (2020). Causes of abortion in dairy cows in Uruguay. Pesq. Vet. Bras. vol.40 no.5. May 2020 Epub July 17, 2020<\/li>\n
          • Moreno P, Moratorio G, Iraola G, Fajardo A, Aldunate F, Pereira-G\u00f3mez MN, Perbolianachis P, Cost\u00e1bile A, L\u00f3pez-Tort F, Sim\u00f3n D, Salazar C, Ferr\u00e9s I, D\u00edaz-Viraqu\u00e9 F, Abin A, Bresque M, Fabregat M, Maidana M, Rivera B, Cruces ME, Rodr\u00edguez-Duarte J, Scavone P, Alegretti M, Nab\u00f3n A, Rosa R, Bidegain E, Zarantonelli L, Piattoni V, Greif G, Francia ME, Robello C, Dur\u00e1n R, Sierra M, Cristina J, Marin M, Ehrlich R, Radi R, Cohen H, Colina R, Barbeito L, Pritsch O, Fern\u00e1ndez C, Badano J, Arim R, Batthy\u00e1ny C, and Interinstitutional COVID-19 Working Group (2020). The Uruguayan Conundrum: key factors for a successful response to the COVID-19 crisis in a South American country. MedRxives preprint: 10.1101\/2020.07.24.20161802<\/li>\n
          • Berna L, Marquez P, Cabrera A, Greif G, Francia ME*, Robello C. (2020) Reevaluation of two Apicomplexans genomes reveals misassembly, karyotype differences and lack of synteny. Genome Research In Press. BioRxiv 2020.05.22.111195; doi.org\/10.1101\/2020.05.22.111195.<\/li>\n<\/ul>\n

            [\/et_pb_accordion_item][et_pb_accordion_item title=”2019″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

              \n
            • Cabrera A, Bern\u00e1 L, Fresia P, Silveira C, Macias Rioseco M, Pritsch O, Riet-Correa F, Giannitti F, Francia ME*, Robello C*. (2019). Characterization of Four Novel Neospora Caninum Strains Reveals Underappreciated Regional and Worldwide diversity. Submitted. *co-corresponding author<\/li>\n<\/ul>\n

              [\/et_pb_accordion_item][et_pb_accordion_item title=”2018″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                \n
              • Berry, L., Chen, CT, Francia, M.E. et al. (2018). Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny. Cell. Mol. Life Sci.<\/li>\n<\/ul>\n

                [\/et_pb_accordion_item][et_pb_accordion_item title=”2017″ _builder_version=”4.16″ _module_preset=”default” link_option_url_new_window=”on” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                  \n
                • Morlon-Guyot J, Francia ME, Dubremetz JF, Daher W. (2017). Towards a molecular architecture of the centrosome in Toxoplasma gondii. Cytoskeleton (Hoboken). 2017 Feb 7; 4(2):55-71.<\/li>\n<\/ul>\n

                  [\/et_pb_accordion_item][et_pb_accordion_item title=”2016″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                    \n
                  • Francia ME#, Dubremetz JF, Morrissette NS. (2016) Basal Body Structure and Composition in the Apicomplexans Toxoplasma and Plasmodium. Review series on Basal Bodies across Eukaryotes. Cilia. Feb 4; 5:3. #corresponding author.<\/li>\n<\/ul>\n

                    [\/et_pb_accordion_item][et_pb_accordion_item title=”Book chapters” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

                      \n
                    • Francia, ME. \u201cToxoplasma cell division; back to the source\u201d in Toxoplasma gondii: Prevalence and Role in Health and Disease, edited by Daniel Adesse and Erica Dos-Santos Martins-Duarte. (2021). Nova Publishers. New York, United States<\/li>\n
                    • Francia, ME, Gissot, M., Modrzynska, K. K., Pawlowic, M. C., eds. (2021). Molecular Basis of Stage Conversion in Apicomplexan Parasites. Lausanne: Frontiers Media SA. doi: 10.3389\/978-2-88966-843-4<\/li>\n<\/ul>\n

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                      Apicomplexan BiologyWe focus on the study of a group of parasites, causative agents of both human and veterinary disease, collectively known as Apicomplexa. We aim to unravel the molecular mechanisms underlying these parasites\u2019s ability to multipy and disseminate. With this, we aim to identify novel drug targets and drugs, to prevent these processes and more […]<\/p>\n","protected":false},"author":8,"featured_media":6075,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[49],"tags":[],"dipi_cpt_category":[],"class_list":["post-4778","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-g4-labs"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=4778"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4778\/revisions"}],"predecessor-version":[{"id":24854715,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4778\/revisions\/24854715"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media\/6075"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=4778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/categories?post=4778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/tags?post=4778"},{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=4778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}