{"id":4781,"date":"2022-03-17T18:00:57","date_gmt":"2022-03-17T18:00:57","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/virus-cell-interactions\/"},"modified":"2024-07-30T19:47:28","modified_gmt":"2024-07-30T19:47:28","slug":"virus-cell-interactions","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/g4-labs\/virus-cell-interactions\/","title":{"rendered":"Virus-Cell Interactions"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”9px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” custom_margin=”|auto|0px|auto|false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” text_font=”Titillium Web|700|||||||” header_font=”Titillium Web|700|||||||” header_text_color=”#005293″ header_font_size=”44px” custom_margin=”||22px|||” header_font_size_tablet=”38px” header_font_size_phone=”29px” header_font_size_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

\n Virus-Cell Interactions<\/span>
\n <\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” custom_padding=”||49px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Viruses have acquired over time the ability to exploit essential cellular functions to enter and replicate in susceptible cells. Viral entry is a fundamental stage of the infective cycle as it is a major determinant of cell tropism, host range, and pathogenesis. Viruses enter cells by various mechanisms and transport routes, and the first step of viral entry is the binding of viral particles to exposed molecules on the cell membrane, such as proteins, lipids, and\/or glycans.<\/p>\n

These molecules can be classified into binding factors, responsible for concentrating viral particles on the cell surface, and cell receptors, molecules that actively promote and mediate viral entry.<\/p>\n

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Likewise, host organisms have developed restriction mechanisms to counteract viral infections, including proteins that block viral entry.<\/p>\n

The main objective of our laboratory is to analyze cellular proteins that modulate viral entry, in order to contribute to the development of antiviral therapies for viruses of importance to human health in Uruguay and the region, such as New World arenaviruses (Jun\u00edn and Machupo), flaviviruses (Zika and Dengue), and coronaviruses (SARS-CoV-2).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”0px||0px|0px|false|false” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” border_color_bottom=”#005293″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_3″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Members” button_alignment=”center” module_class=”df-button dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Research lines” button_alignment=”center” module_class=”df-button dfc-investigacion” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;||letter-spacing: -0.5px;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Main publications” button_alignment=”center” module_class=”df-button dfc-publicaciones” _builder_version=”4.14.6″ _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#005293″ button_bg_color=”rgba(0,82,147,0.16)” button_border_width=”0px” button_border_color=”#005293″ button_border_radius=”0px” button_font=”|700|||||||” button_use_icon=”off” transform_scale=”97%|97%” custom_padding=”10px||10px||false|false” custom_css_main_element=”width: 100% !important;” global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Nicol\u00e1s Sarute, PhD” position=”Head ” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2023\/12\/Sarute-Nicolas.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/responsables-cientificos-y-de-apoyo\/nicolas-sarute\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

nsarute@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Kathia Guardado, PhD” position=”Postdoc” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2023\/12\/Aguilar-Guardado-Kathia.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

kaguilar@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Natalia Ans\u00edn, BSc” position=”Master’s degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/07\/Ansin-Natalia.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

nansin@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Camila Ladra” position=”Research assistant” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/07\/Ladra-Camila.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” hover_enabled=”0″ global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content” title_text=”Ladra, Camila” sticky_enabled=”0″]<\/p>\n

cladra@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Mar\u00eda Paz Garc\u00eda” position=”Student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2024\/07\/Garcia-Maria-Paz.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url=”https:\/\/pasteur.uy\/responsables-cientificos-y-de-apoyo\/nicolas-sarute\/” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

mpgarcia@pasteur.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”27px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Analysis of intrinsic viral restriction factors<\/strong> as potential therapeutic targets.<\/p>\n

Study of cellular proteins<\/strong> that modulate viral endocytosis.<\/p>\n

Innate antiviral immune response.<\/strong><\/p>\n

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Main publications<\/h2>\n

[\/et_pb_text][et_pb_accordion icon_color=”#005293″ _builder_version=”4.14.6″ _module_preset=”default” toggle_text_color=”#005293″ toggle_font=”Titillium Web|600|||||||” toggle_font_size=”17px” custom_margin=”||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_accordion_item title=”vacio” open=”on” _builder_version=”4.14.6″ _module_preset=”default” custom_css_main_element=”display:none” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_accordion_item][et_pb_accordion_item title=”2021″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

    \n
  • Sarute N, Cheng H, Yan Z, Salas-Briceno K, Richner J, Rong L, Ross SR (2021). Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. PLoS Pathog. 17(6):e1009662. https:\/\/doi.org\/10.1371\/journal.ppat.1009662<\/li>\n
  • Sarute N, Ross SR (2021). The board is set, the pieces are moving: Modulation of New World arenavirus entry by host proteins. PLoS Pathog. 17(6):e1009605.https:\/\/doi.org\/10.1371\/journal.ppat.1009605<\/li>\n<\/ul>\n

    [\/et_pb_accordion_item][et_pb_accordion_item title=”2020″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

      \n
    • Sarute N, Ross SR (2020). CACNA1S haploinsufficiency confers resistance to New World arenavirus infection. Proc Natl Acad Sci USA. 117(32): 19497-19506. https:\/\/doi.org\/10.1073\/pnas.1920551117.<\/li>\n
    • Li* JJ, Sarute* N, Lancaster E, Otkiran-Clare G, et al (2020). A recessive Trim2 mutation causes an axonal neuropathy in mice. Neurobiol Dis, 140:104845. https:\/\/doi.org\/10.1016\/j.nbd.2020.104845. *Co-first<\/li>\n<\/ul>\n

      [\/et_pb_accordion_item][et_pb_accordion_item title=”2019″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

        \n
      • Sarute N, Ibrahim N, Medegan Fagla B, et al (2019). TRIM2, a novel member of the antiviral family, limits new world arenavirus entry. PLoS Biol 17 (2): e3000137. https:\/\/doi.org\/10.1371\/journal.pbio.3000137.<\/li>\n<\/ul>\n

        [\/et_pb_accordion_item][et_pb_accordion_item title=”2017″ _builder_version=”4.14.6″ _module_preset=”default” link_option_url_new_window=”on” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

          \n
        • Sarute N, Ross SR (2017). New World Arenavirus Biology. Annual Reviews of Virology, 4(1):141-158. doi: 10.1146\/annurev-virology-101416-042001.<\/li>\n<\/ul>\n

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          Virus-Cell Interactions Viruses have acquired over time the ability to exploit essential cellular functions to enter and replicate in susceptible cells. Viral entry is a fundamental stage of the infective cycle as it is a major determinant of cell tropism, host range, and pathogenesis. Viruses enter cells by various mechanisms and transport routes, and the […]<\/p>\n","protected":false},"author":8,"featured_media":6081,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[49],"tags":[],"dipi_cpt_category":[],"class_list":["post-4781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-g4-labs"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=4781"}],"version-history":[{"count":5,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4781\/revisions"}],"predecessor-version":[{"id":24848204,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/4781\/revisions\/24848204"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media\/6081"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=4781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/categories?post=4781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/tags?post=4781"},{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=4781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}