{"id":5424,"date":"2022-04-04T20:28:14","date_gmt":"2022-04-04T20:28:14","guid":{"rendered":"https:\/\/pasteur.uy\/uncategorized\/cell-biology-of-neural-development\/"},"modified":"2022-04-04T20:29:48","modified_gmt":"2022-04-04T20:29:48","slug":"cell-biology-of-neural-development","status":"publish","type":"post","link":"https:\/\/pasteur.uy\/en\/previous-laboratories\/cell-biology-of-neural-development\/","title":{"rendered":"Cell Biology of Neural Development"},"content":{"rendered":"

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Cell Biology of Neural Development<\/h1>\n

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The laboratory was a joint group integrated by researchers from the IP Montevideo and the Faculty of Sciences (Udelar). Its work was focused on the relationship between cell polarity \u2014that is, the asymmetries that allow cells to have specific functions\u2014 and neural differentiation, the phase of development of neurons in which they acquire the morphological and physiological characteristics of its mature stage.<\/span><\/p>\n

To study these phenomena, the laboratory used experimental systems in vertebrates such as zebrafish and chicken, to analyse of the function of diverse proteins that have an impact on neuronal development. Based on this, the group characterized on both species the functions of a family of proteins (\u201cMARCKS\u201d) and the genes that encode them, in the initial formation of the embryonic nervous system (phase known as \u201cneurulation\u201d).<\/p>\n

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The lab also characterized the function of primary cilia have in neuronal formation in the retina of zebrafish, and has presented evidence indicating that the extracellular matrix protein Laminin 1 is essential for the formation of axon of those same neurons, among other investigations.<\/p>\n

The group also participated in undergraduate and postgraduate teaching activities, as well as in various scientific dissemination initiatives.<\/p>\n

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global_colors_info=”{}” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#005293″ button_bg_enable_color__hover=”on” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” module_class=”df-area df-rows dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” custom_padding=”16px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Members<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” custom_padding=”||6px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Flavio R. Zolessi, PhD” position=”Head ” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/04\/Zolessi-Flavio.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” link_option_url_new_window=”on” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Science, Udelar
<\/span>fzolessi@fcien.edu.uy<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Gonzalo Aparicio, MSc” position=”Doctoral student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/04\/Aparicio-Gonzalo.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Science, Udelar<\/span><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Camila Davison, BSc” position=”Doctoral student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/03\/Davison-Camila.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Science, Udelar<\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Magela Rodao, BSc” position=”Master’s degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/04\/Rodao-Magela.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”]<\/p>\n

Faculty of Science, Udelar<\/span><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ module_class=”dfc-integrantes” _builder_version=”4.14.6″ _module_preset=”default” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_team_member name=”Luc\u00eda Veloz, BSc” position=”Master’s degree student” image_url=”https:\/\/pasteur.uy\/wp-content\/uploads\/2022\/04\/Veloz-Lucia.jpg” _builder_version=”4.14.6″ _module_preset=”default” header_font=”|700|||||||” body_font=”|300|||||||” position_font=”|600|||||||” position_text_color=”#005293″ position_line_height=”25px” animation_style=”fade” global_colors_info=”{}” position__hover_enabled=”off|desktop” theme_builder_area=”post_content”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ module_class=”dfc-humano” _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.14.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-investigacion” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Research lines<\/h2>\n

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Role of Laminin 1 and Slit-Robo signalling in retinal ganglion cells differentiation.<\/strong>
We have previously demonstrated that Laminin 1 from the retinal basal lamina acts as a positive signal for axon outgrowth at the basal side. Our current working hypothesis is that negative signals inside the retina, like Slit factors, would reinforce the correct orientation of retinal ganglion cells, preventing axon outgrowth in other directions.<\/p>\n

Characterization of primary cilia in early stages of photoreceptor cell differentiation.<\/strong>
After showing that retinal ganglion cells and their progenitors have a small primary cilium, which is important for their genesis and correct localization in the retina, we have started to analyse the possibility that this organelle also has a function at early stages of photoreceptor cell differentiation.<\/p>\n

Polarized signals in the localization and orientation of photoreceptors.<\/strong>
We propose that, like retinal ganglion cells, photoreceptors respond to extracelular signals present in the retina, which are necessary for giving them their apropriate orientation. We investigate the possible role in this process of subapical adhesion molecules, such as N-Cadherin, and others necessary for cell polarity, like Pals1\/Nok.<\/p>\n

Role of MARCKS proteins in the modulation of polarity transitions in vertebrate neurulation.<\/strong>
We have found that MARCKS family proteins are important for neurolation in both chick and zebrafish embryos, aparently by modulating cell polarity in the neural plate. However, there are different cell mechanisms for neurulation in each of these species, which could be related with the duplication of Marcks genes in the fish.<\/p>\n

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Courses<\/h2>\n

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    \n
  • Course on Processing and Analysis of Fluorescence Microscopy Images (PAFMI), Uruguay. Organizers: F. Zolessi, F. Lecumberry, P. Aguilar. 29\/02-11\/03\/2016.<\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-proyectos” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Projects<\/h2>\n

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    2015-2018<\/strong> \u2013 \u201cNeural orientation in the polarized environment of the developing neural retina: influence of Slit proteins\u201d. Responsible: Flavio Zolessi. FCE-ANII.<\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”dfc-publicaciones” _builder_version=”4.14.6″ _module_preset=”default” max_width=”80%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.14.6″ _module_preset=”default” header_2_font=”|700|||||||” header_2_text_color=”#005293″ header_2_font_size=”35px” custom_margin=”||0px||false|false” custom_padding=”||26px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”29px” header_2_font_size_last_edited=”on|phone” saved_tabs=”all” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    Main publications<\/h2>\n

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    *Aparicio G., Arruti C., Zolessi F.R. (2018) MARCKS phosphorylation by PKC strongly impairs cell polarity in the chick neural plate. Genesis 56(4): e23104. doi: 10.1002\/dvg.23104.<\/p>\n

    Paravani E.V., Simoniello M.F., Poletta G.L., Zolessi F.R., Casco V.H. (2018) Cypermethrin: Oxidative stress and genotoxicity in retinal cells of the adult zebrafish. Mutat Res. 826:25-32. doi: 10.1016\/j.mrgentox.2017.12.010.<\/p>\n

    Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, Gonz\u00e1lez-Sapienza G, Irigo\u00edn F, Badano JL. (2018) Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Sci Rep. 8(1):3019. doi: 10.1038\/s41598-018-21329-6.<\/p>\n

    [\/et_pb_accordion_item][et_pb_accordion_item title=”2017″ _builder_version=”4.14.6″ _module_preset=”default” link_option_url_new_window=”on” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

    *Prieto D., Zolessi F.R. (2017) Functional diversification of the four MARCKS family members in zebrafish neural development. J. Exp. Zool. (Mol. Dev. Evol.) 328(1-2):119-138. doi: 10.1002\/jez.b.22691.<\/p>\n

    \u00c1lvarez G., Perdomo C., Coronel C., Aguilera E., Varela J., Aparicio G., Zolessi F.R., Cabrera N., Vega C., Rol\u00f3n M., Rojas De Arias A., P\u00e9rez-Montfort R., Cerecetto H., Gonz\u00e1lez M. (2017) Multi-anti-parasitic activity of arylideneketones and thiazolidenehydrazines against Trypanosoma cruzi and Leishmania spp. Molecules 22(5). pii: E709. doi: 10.3390\/molecules22050709.<\/p>\n

    Prieto D, Aparicio G, Sotelo-Silveira JR. (2017) Cell migration analysis: A low-cost laboratory experiment for cell and developmental biology courses using keratocytes from fish scales. Biochem Mol Biol Educ. 45(6):475-482. doi: 10.1002\/bmb.21071.<\/p>\n

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    *Lepanto P., Badano J.L., Zolessi F.R. (2016) Neuron\u2019s little helper: the role of primary cilia in neurogenesis. Neurogenesis. 3:1, e1253363. doi: 10.1080\/23262133.2016.1253363.<\/p>\n

    *Zolessi F.R. (2016) Vertebrate neurogenesis: cell polarity (v. 3). Encyclopedia of Life Sciences (Wiley). DOI: 10.1002\/9780470015902.a0000826.pub3.<\/p>\n

    *Lepanto P., Davison C., Casanova G., Badano J.L., Zolessi F.R. (2016) Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish. Neural Dev. 11(1):10. doi: 10.1186\/s13064-016-0064-z.<\/p>\n

    [\/et_pb_accordion_item][et_pb_accordion_item title=”2015″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

    *Prieto D., Aparicio G., Machado, M., Zolessi F.R. (2015) Application of the DNA-Specific Stain Methyl Green in the Fluorescent Labeling of Embryos. J. Vis. Exp. (99), e52769, doi: 10.3791\/52769.<\/p>\n

    Paolini A, Duchemin AL, Albadri S, Patzel E, Bornhorst D, Gonz\u00e1lez Avalos P, Lemke S, Machate A, Brand M, Sel S, Di Donato V, Del Bene F, Zolessi F.R., Ramialison M, Poggi L. (2015) Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Development 142(5): 832-9. doi: 10.1242\/dev.118612.<\/p>\n

    [\/et_pb_accordion_item][et_pb_accordion_item title=”2014″ _builder_version=”4.14.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” open=”off”]<\/p>\n

    *Prieto D., Aparicio G., Morande P.E., Zolessi F.R. (2014) A fast, low cost, and highly efficient fluorescent DNA labeling method using methyl green. Histochem Cell Biol 142(3): 335-345. doi: 10.1007\/s00418-014-1215-0.<\/p>\n

    Tinoco L.W., Fraga J.L., AnoBom C.D., Zolessi F.R., Obal G., Toledo A., Pritsch O., Arruti C. (2014) Structural characterization of a neuroblast-specific phosphorylated region of MARCKS. Biochim Biophys Acta 1844(4): 837-849. doi: 10.1016\/j.bbapap.2014.02.016.<\/p>\n

    [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

    Cell Biology of Neural DevelopmentThe laboratory was a joint group integrated by researchers from the IP Montevideo and the Faculty of Sciences (Udelar). Its work was focused on the relationship between cell polarity \u2014that is, the asymmetries that allow cells to have specific functions\u2014 and neural differentiation, the phase of development of neurons in which […]<\/p>\n","protected":false},"author":8,"featured_media":5395,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[50],"tags":[],"dipi_cpt_category":[],"class_list":["post-5424","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-previous-laboratories"],"acf":[],"_links":{"self":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/5424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/comments?post=5424"}],"version-history":[{"count":3,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/5424\/revisions"}],"predecessor-version":[{"id":5427,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/posts\/5424\/revisions\/5427"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media\/5395"}],"wp:attachment":[{"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/media?parent=5424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/categories?post=5424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/tags?post=5424"},{"taxonomy":"dipi_cpt_category","embeddable":true,"href":"https:\/\/pasteur.uy\/en\/wp-json\/wp\/v2\/dipi_cpt_category?post=5424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}