Rosario Durán 2018-11-23T12:46:41+00:00
PhD Rosario Durán
PhD Rosario Durán

UNIDAD MIXTA DE BIOQUÍMICA Y PROTEÓMICA ANALÍTICAS (IP MONTEVIDEO-IIBCE)

  • Doctorado en Química, Pedeciba, Facultad de Química, Udelar, Uruguay (2003 – 2007).

  • Bachiller en Química, Facultad de Química, Udelar, Uruguay (1983 – 1989).

  • Química Farmacéutica, Facultad de Química, Udelar, Uruguay (1983 – 1992).

  • Proteómica

  • Mycobacterium tuberculosis

  • Espectrometría de masa

  • Parodi-Talice, A., Durán, R., Arrambide, N., Prieto, V., Pineyro, M.D., Pritsch, O., Cayota, A., Cervenansky, C., Robello, C. Proteome analysis of the causative agent of Chagas disease: Trypanosoma cruzi. Int J Parasitol. 34: 881-6 (2004).

  • Prieto D., Zolessi F.R. (2017) Functional diversification of the four MARCKS family members in zebrafish neural development. J. Exp. Zool. (Mol. Dev. Evol.) 328(1-2):119-138. doi: 10.1002/jez.b.22691.

  • 1. Durán, R., Villarino, A., Bellinzoni, M., Wehenkel, A., Fernandez, P., Boitel, B., Cole, S.T., Alzari, P.M., Cervenansky, C. Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases. Biochem. Biophys. Res. Commun. 333:858-67 (2005).

  • 2. Villarino*, A., Durán*, R., Wehenkel, A., Fernandez, P., England, P., Brodin, P., Cole, S.T., Zimny-Arndt, U., Jungblut, P.R., Cervenansky, C., Alzari, P.M. Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J. Mol. Biol. 350:953-63 (2005). * These authors have equally contributed to the work.

  • O´Hare, H; Durán, R; Cerveñansky,C, Bellinzoni, M.; Wehenkel, A.; Pritsch, O.; Obal, G; Baumgartner, J; Johnsson,K; Alzari, PM. Regulation of glutamate metabolism by protein kinases in mycobacteria. Molecular Microbiology 70, 1408-1423 (2008).

  • Binolfi A, Lamberto GR, Durán,R, Quintanar L, Bertoncini CW, Souza JM, Cerveñansky C, Zweckstetter M, Griesinger C, Fernández C.O. Site-specific interactions of Cu(II) with synucleins: bridging the molecular gap between metal binding and aggregation. J. Am. Chem. Soc. 130, 11801-11812 (2008).

  • Gil M, Graña M, Schopfer FJ, Wagner T, Denicola A, Freeman BA, Alzari PM, Batthyány C, Durán R. Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center. Free Radic. Biol. Med. 65, 150–161 (2013).

  • 5. Rossello J, Lima A, Gil M, Rodríguez Duarte J, Correa A, Carvalho PC, Kierbel A, Durán R. The EAL-domain protein FcsR regulates flagella, chemotaxis and type III secretion system in Pseudomonas aeruginosa by a phosphodiesterase independent mechanism. Sci Rep. 7:10281(2017)