Virginia López
Virginia López, PhD
Laboratorio de Síntesis Orgánica
y desarrollo de fármacos
- Doctora en Química, Universidad de la República, PEDECIBA-Química, Uruguay, 2006.
- Química Farmacéutica, Universidad de la República, Uruguay, 2002.
- Varela, M.; López, M.; Ingold, M.; Alem, D.; Perini, V.; Perelmuter, K.; Bollati-Fogolín, M.; López, G.V.; Hernández, P. New Nitric Oxide-Releasing Compounds as Promising Anti-Bladder Cancer Drugs. Biomedicines 2023, 11, 199. https://doi.org/10.3390/biomedicines11010199
- F. Ortiz, T. Tassano, M. Ingold, V. de la Sovera, A. Puerta, J.M. Padrón, G.V. López,* W. Porcal.* Greener approach for the synthesis of nitrovinylfurans from biomass-derived 5-hydroxymethyfurfural as selective antiproliferative agents. Sustain. Chem. Pharm. 2022, 30, 100828. https://doi.org/10.1016/j.scp.2022.100828
- M. Ingold, V. de la Sovera, R. Dapueto, W. Porcal,* G.V. López.* Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions. Molecules 2022, 27(6), 1756; https://doi.org/10.3390/molecules27061756.
- V. de la Sovera, G.V. López,* W. Porcal.* Synthetic Study of 5-Hydroxymethylfurfural in Groebke-Blackburn-Bienaymé Reaction. Eur. J. Org. Chem. 2022. https://doi.org/10.1002/ejoc.202101369.
- R. Dapueto, J. Rodriguez-Duarte, G. Galliussi, A. Kamaid, M. Bresque, C. Batthyány,* G.V. López,* C. Escande,* A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity, Redox Biology 2021, 39, 101833. https://doi.org/10.1016/j.redox.2020.101833.
- S. Ibarburu, M. Kovacs, V. Varela, J. Rodríguez-Duarte, M. Ingold, P. Invernizzi, W. Porcal, A.P. Arévalo, K. Perelmuter, M. Bollati-Fogolín, C. Escande, G.V. López, P. King, Y. Si, Y. Kwon, C. Batthyány, L. Barbeito,* E. Trias.* A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition. Neurotherapeutics 2020. https://doi.org/10.1007/s13311-020-00953-z.
- J. Rodriguez-Duarte, G. Galliussi, R. Dapueto, J. Rossello, L. Malacrida, A. Kamaid, F.J. Schopfer, C. Escande,* Gloria V. López,* C. Batthyány* A novel nitroalkene-α-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in apoE knockout mice, Br. J. Pharmacol. 2019, 176(6), 757-772. https://doi.org/10.1111/bph.14561.
- M. Ingold, R. Dapueto, S. Victoria, G. Galliussi, C. Batthyány, M. Bollati-Fogolín, D. Tejedor Aragón, F. García-Tellado, José M. Padrón, W. Porcal,* Gloria V. López.* A green multicomponent synthesis of Tocopherol analogues with antiproliferative activities. Eur. J. Med. Chem. 2018, 143, 1888-1902. DOI: 10.1016/j.ejmech.2017.11.003.
- M. Ingold, Gloria V. López,* W. Porcal.* Green conditions for Passerini three-component synthesis of Tocopherol analogues. ACS Sustain. Chem. Eng. 2014, 2, 1093 – 1097. https://doi.org/10.1021/sc5002116.
- Gloria V. López; M. Cabrera; Luis E. Gómez; M. Breijo; C. Pintos; H. Botti; S. Raymondo; A. Vettorazzi; A. López De Cerain; A. Monge; H. Rubbo; M. González; H. Cerecetto Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents. Drug Chem. Toxicol. 2011, 34 (3), 285-293. https://doi.org/10.3109/01480545.2010.536769.
- Gloria V. López;* Luis E. Gómez; N. Campillo; Juan A Páez; K. Giles; J. Atkinson; M. González; H. Rubbo; H. Cerecetto Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity. Bioorg. Med. Chem. 2009, 17, 8143-8148. https://doi.org/10.1016/j.bmc.2009.10.046.
- López G.V., Blanco F., Hernández P., Ferreira A., Piro O.E., Batthyány C., González M., Rubbo H., Cerecetto H Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical and biological characterization Bioorg. Med. Chem. 2007, 15, 6262-6272. https://doi.org/10.1016/j.bmc.2007.06.019.
- López G.V., Batthyány C., Blanco F., Botti H., Trostchansky A., Migliaro E., Radi R., González M., Cerecetto H. and Rubbo H., Design, Synthesis and Biological Characterization of Novel Antiatherogenic Tocopherol Analogs-Nitric Oxide Donors, Bioorg. Med. Chem. 2005, 13, 5787-5796. https://doi.org/10.1016/j.bmc.2005.05.060.
- Química medicinal
- Química orgánica
- Química verde
- Enfermedades crónicas no transmisibles