Chronic Lymphoid Leukemia Lab
Recombinant Proteins Unit
PhD in Immunology, Doctoral School of Biochemistry and Molecular Biology, Universite de Paris VI (Pierre et Marie Curie), France (2001 – 2005)
MScin BiologicalSciences, Pedeciba, Udelar, Uruguay (1996 – 1998)
BSc in Geneticaand Pharmacy, Universidad Nacional de Misiones, Argentina (1990 – 1995)
Immunology
Hematology
Chronic Lymphoid Leukemia
Recombinant proteins
S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression.Prieto D, Sotelo N, Seija N, Sernbo S, Abreu C, Durán R, Gil M, Sicco E, Irigoin V, Oliver C, Landoni AI, Gabus R, Dighiero G, Oppezzo P. Blood. 2017, Aug 10;130(6):777-788. doi: 10.1182/blood-2017-02-769851.
Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination. Almejún MB, Campos BC, Patiño V, Galicchio M, Zelazko M, Oleastro M, Oppezzo P, Danielian S. J Allergy Clin Immunol. 2017, Mar;139(3):913-922. doi: 10.1016/j.jaci.2016.08.030.
Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation. Palacios F, Abreu C, Prieto D, Morande P, Ruiz S, Fernández-Calero T, Naya H, Libisch G, Robello C, Landoni AI, Gabus R, Dighiero G, Oppezzo P. Leukemia. 2015, Jan;29(1):115-25. doi: 10.1038/leu.2014.158.
“Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia”. Oppezzo P, Dighiero G. Blood Cancer J. 2013, Sep 20;3:e149. doi: 10.1038/bcj.2013.45.
Post-transcriptional regulation of Inducible Nitric Oxide Synthase in Chronic Lymphocytic Leukemia B cells in pro-apoptotic and anti-apoptotic culture conditions. Tiscornia, A.; Cayota, A.; Landoni A.I.; Brito, C.;Oppezzo, P.; Vuillier, F.; Robello, C.; Dighiero, G.; Gabús, R.; Pritsch, O. Leukemia 18: 48-56, 2004
Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment. Moreno P, Abreu C, Borge M, Palacios F, Morande P, Pegazzano M, Bianchi S, Landoni AI, Agrelo R, Giordano M, Dighiero G, Gamberale R, Oppezzo P. Leukemia. 2013, Mar;27(3):721-5. doi: 10.1038/leu.2012.212. Epub 2012 Jul 25
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Palacios F, Moreno P, Morande P, Abreu C, Correa A, Porro V, Landoni AI, Gabus R, Giordano M, Dighiero G, Pritsch O, Oppezzo P. Blood. 2010, Jun 3;115(22):4488-96. doi: 10.1182/blood-2009-12-257758.
What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis? Oppezzo P, Dighiero G. Curr Top Microbiol Immunol. 2005; 294:71-89. Review
The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia. Oppezzo P, Vasconcelos Y, Settegrana C, Jeannel D, Vuillier F, Legarff-Tavernier M, Kimura EY, Bechet S, Dumas G, Brissard M, Merle-Béral H, Yamamoto M, Dighiero G, Davi F; French Cooperative Group on CLL. Blood. 2005 Jul 15;106(2):650-7.
Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells. Oppezzo P, Dumas G, Lalanne AI, Payelle-Brogard B, Magnac C, Pritsch O, Dighiero G, Vuillier F. Blood. 2005, Mar 15;105(6):2495-503.
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation. Oppezzo P, Vuillier F, Vasconcelos Y, Dumas G, Magnac C, Payelle-Brogard B, Pritsch O, Dighiero G. Blood. 2003, May 15;101(10):4029-32.
