Carlos Escande 2018-09-12T18:03:14+00:00
PhD Carlos Escande
PhD Carlos Escande

LABORATORIO DE PATOLOGÍAS DEL METABOLISMO Y EL ENVEJECIMIENTO

  • Posdoctorado. Rol of the SIRT1 protein inhibitor, Deleted in breast cancer 1, in endothelial cell activation and atherosclerosis, Mayo Clinic and Foudation, Estados Unidos (2010 – 2013).

  • Doctorado en Ciencias Biológicas, Facultad de Ciencias, Pedeciba, Udelar, Uruguay y Mayo Clinic and Foundation (2007-2010).

  • Maestría en Ciencias Biológicas, Facultad de Ciencias, Pedeciba, Udelar, Uruguay (2004-2007).

  • Licenciatura en Ciencias Biológicas, Facultad de Ciencias, Universidad de la República, Uruguay (1998-2004).

  • Aterosclerosis

  • Enfermedades inflamatorias

  • Metabolismo

  • Obesidad

  • Diabetes tipo II

  • Prieto-Echagüe V, Lodh S, Colman L, Bobba N, Santos L, Katsanis N, Escande C, Zaghloul NA, Badano JL. BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1. Sci Rep. 2017 Aug 29;7(1):9765. doi: 10.1038/s41598-017-10330-0. PubMed PMID: 28852127.

  • Matalonga J, Glaria E, Bresque M, Escande C, Carbó JM, Kiefer K, Vicente R, León TE, Beceiro S, Pascual-García M, Serret J, Sanjurjo L, Morón-Ros S, Riera A, Paytubi S, Juarez A, Sotillo F, Lindbom L, Caelles C, Sarrias MR, Sancho J, Castrillo A, Chini EN, Valledor AF. The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism. Cell Rep. 2017 Jan 31;18(5):1241-1255. doi: 10.1016/j.celrep.2017.01.007. PubMed PMID: 28147278.

  • Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016 Jun 14;23(6):1127-39. doi: 10.1016/j.cmet.2016.05.006. PubMed PMID: 27304511; PubMed Central PMCID: PMC4911708.

  • Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway. Clin Cancer Res. 2016 May 15;22(10):2496-507. doi: 10.1158/1078-0432.CCR-15-1760. PubMed PMID: 26655844; PubMed Central PMCID: PMC4867252.

  • Santos L, Escande C, Denicola A. Potential Modulation of Sirtuins by Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9831825. doi: 10.1155/2016/9831825. Epub 2015 Dec 14.

  • Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway. Clin Cancer Res. 2015

  • Mathison A*, Escande C*, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R. Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. Endocrinology. 2015 Oct;156(10):3581-95. Shared first authorship

  • Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging (Albany NY). 2014 Jul 20. [Epub ahead of print] PubMed PMID: 25063774.