Carlos Escande

Carlos Escande, PhD


  • Posdoc. Rol of the SIRT1 protein inhibitor, Deleted in breast cancer 1, in endothelial cell activation and atherosclerosis, Mayo Clinic and Foudation, Estados Unidos (2010 – 2013).
  • PhD in Biological Science, Faculty of Science, Pedeciba, Udelar, Uruguay y Mayo Clinic and Foundation (2007-2010).
  • MSc in Biological Science, Faculty of Science, Pedeciba, Udelar, Uruguay (2004- 2007).
  • BSc in Biological Science, Faculty of Science, Universidad de la República, Uruguay (1998-2004).
  • Atherosclerosis
  • Inflammatory diseases
  • Metabolism
  • Obesity
  • Type II Diabetes
  • Bresque M, Cal K, Pérez-Torrado V, Colman L, Rodríguez-Duarte J, Vilaseca C, Santos L, Garat MP, Ruiz S, Evans F, Dapueto R, Contreras P, Calliari A, Escande C. SIRT6 stabilization and cytoplasmic localization in macrophages regulates acute and chronic inflammation in mice. J Biol Chem. 2022 Mar;298(3):101711. doi: 10.1016/j.jbc.2022.101711. Epub 2022 Feb 9. PMID: 35150745; PMCID: PMC8913316.
  • Dapueto R, Rodriguez-Duarte J, Galliussi G, Kamaid A, Bresque M, Batthyány C, López GV, Escande C. A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity. Redox Biol. 2021 Feb;39:101833. doi: 10.1016/j.redox.2020.101833. Epub 2020 Dec 15. PMID: 33352465; PMCID: PMC7750735.
  • Colman L, Caggiani M, Leyva A, Bresque M, Liechocki S, Maya-Monteiro CM, Mazal D, Batthyany C, Calliari A, Contreras P, Escande C. The protein Deleted in Breast Cancer-1 (DBC1) regulates vascular response and formation of aortic dissection during Angiotensin II infusion. Sci Rep. 2020 Apr 21;10(1):6772. doi: 10.1038/s41598-020-63841-8.
  • Santos L, Colman L, Contreras P, Chini CC, Carlomagno A, Leyva A, Bresque M, Marmisolle I, Quijano C, Durán R, Irigoín F, Prieto-Echagüe V, Vendelbo MH, Sotelo-Silveira JR, Chini EN, Badano JL, Calliari AJ, Escande C. A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo. Sci Rep. 2019 Oct 7;9(1):14381. doi: 10.1038/s41598-019-50789-7. PubMed PMID: 31591441; PubMed Central PMCID:PMC6779753.
  • Rodriguez-Duarte J, Galliussi G, Dapueto R, Rossello J, Malacrida L, Kamaid A, Schopfer FJ, Escande C, López GV, Batthyány C. A novel nitroalkene-α-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in Apo E knockout mice. Br J Pharmacol. 2019 Mar;176(6):757-772. doi: 10.1111/bph.14561. Epub 2019 Feb 3. PubMed PMID: 30588602; PubMed Central PMCID: PMC6393233.
  • Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016 Jun 14;23(6):1127-39. doi: 10.1016/j.cmet.2016.05.006. PubMed PMID: 27304511; PubMed Central PMCID: PMC4911708.
  • Escande C, Nin V, Pirtskhalava T, Chini CC, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype. Diabetes. 2014 Jul 22. pii: DB_140192. [Epub ahead of print] PubMed PMID: 25053585.
  • Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell. 2014 Jul 3. doi: 10.1111/acel.12235. [Epub ahead of print] PubMed PMID: 24992635.
  • Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O’Neil L, White TA, Sinclair DA, Chini EN. The flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr;62(4):1084-93.
  • Nin V*, Escande C*, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN. Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem. 2012 Jul 6;287(28):23489-501 * Shared first authorship
  • Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010 Feb 1;120(2):545-58.