Carlos Batthyány

PhD, MD Carlos Battyány

Vascular Biology and
Drug Development Laboratory

  • Postdoctoral Research Fellow and Research Fellow, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Research area: drug development for conditions related to inflammation. (2006-2007).
  • Postdoctoral Fellow, Center for Free Radical Biology, University of Alabama at Birmingham, AL, USA. Research area: Free Radical Biology and Inflammatory Mediators. (2004-2006).
  • Ph.D in Biochemistry, Faculty of Science (Udelar) and Pedeciba, Uruguay. Dissertation: “Inflammatory oxidants and atherosclerosis: role of nitric oxide-derived species” (2005).
  • MSc. in Biochemistry, Faculty of Science (Udelar), Pedeciba, Uruguay. Dissertation: “Amino acid sequence and three-dimensional structure of Tn-specific isolectin B4 from Vicia villosa” (1997).
  • Doctor of Medicine (MD), Faculty of Medicine, University of the Republic, Uruguay (1996).
  • Vascular biology
  • Drug development
  • Inflammation related diseases
  • Pharmacology
  • Transgenesis
  • Atherosclerosis
  • Batthyany, C., Souza JM, Durán R, Cassina A, Cerveñansky C and Radi R. Time course and site(s) of cytochrome c tyrosine nitration by peroxynitrite. Biochemistry 44, 8038-8046, 2005.
  • Batthyany, C., Schopfer, F. J., Baker, P. R., Duran, R., Baker, L. M., Huang, Y., Cervenansky, C., Branchaud, B. P., and Freeman, B. A. Reversible post-translational modification of proteins by nitrated fatty acids in vivo. J Biol Chem 281, 20450-63, 2006.
  • Batthyany, C., Kelley, E. E., Hundley, N. J., Woodcock, S. R., Bonacci, G., Del Rio, J. M., Schopfer, F. J., Lancaster, J. R., Jr., Freeman, B. A., and Tarpey, M. M. Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase. J Biol Chem 283, 36176-84, 2008 (co-first author).
  • Schopfer, F. J., Batthyany, C., Baker, P. R., Bonacci, G., Cole, M. P., Rudolph, V., Groeger, A. L., Rudolph, T. K., Nadtochiy, S., Brookes, P. S., and Freeman, B. A. Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives. Free Radic Biol Med 46, 1250-9, 2009.
  • Khoo, N. K., Rudolph, V., Cole, M. P., Golin-Bisello, F., Schopfer, F. J., Woodcock, S. R., Batthyány, C. & Freeman, B. A. Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids. Free radical biology & medicine 48, 230-239, doi:10.1016/j.freeradbiomed.2009.10.046 (2010).
  • Bonacci, G., Schopfer, F. J., Batthyány, C., Rudolph, T. K., Rudolph, V., Khoo, N. K., Kelley, E. E. & Freeman, B. A. Electrophilic fatty acids regulate matrix metalloproteinase activity and expression. The Journal of biological chemistry 286, 16074-16081, doi:10.1074/jbc.M111.225029 (2011).
  • Gil, M., Grana, M., Schopfer, F. J., Wagner, T., Denicola, A., Freeman, B. A., Alzari, P. M., Batthyány, C. & Duran, R. Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center. Free radical biology & medicine 65, 150-161, doi:10.1016/j.freeradbiomed.2013.06.021 (2013).
  • Batthyány, C., Bartesaghi, S., Mastrogiovanni, M., Lima, A., Demicheli, V. & Radi, R. Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects. Antioxidants & redox signaling, doi:10.1089/ars.2016.6787 (2016).