Gustavo Salinas

Gustavo Salinas, PhD

Worm Biology Laboratory

  • PhD in Biochemistry and Molecular Biology. “Characterisation and molecular cloning of glutathione S-transferses from Onchocerca volvulus”, University of Cambridge, United Kingdom (1991 – 1995).

  • Pharmaceutical chemist, Faculty of Chemistry, University of the Republic, Uruguay (1982 – 1989).

  • Parasitology

  • Redox Biology

  • Metabolism

  • C. elegans

  • Helminth

  • Worm Biology Laboratory

  • Molecular parasitology

  • Nematode

  • Antioxidant enzymes

  • Salinas G, Gao W, Wang Y, Bonilla M, Novikov A, Virginio VG, Ferreira HB, Vieites M , Gladyshev VN, Gambino D, Dai S. (2017) The enzymatic and structural basis for inhibition of Echinococcus granulosus thioredoxin glutathione reductase by gold(I). Antiox Redox Signal 27(18):1491-1504. Portada de la revista.
  • Romanelli-Cedrez L, Carrera I, Otero L, Miranda-Vizuete A, Mariotti M, Alkema MJ, Salinas G. (2017) Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans. Free Radic Biol Med 108:174-182.
  • Bisio H, Bonilla M, Manta B, Graña M, Salzmand V, Aguilar PS, Gladyshev VN, Comini M, Salinas G (2016) A new class of thioredoxin-related protein able to bind iron-sulfur clusters. Antiox Redox Signal 24(4):205-216.
  • Otero L, Romanelli-Cedrez L, Turanov AA, Gladyshev VN, Miranda-Vizuete A, Salinas G (2014) Adjustments, extinction and remains of selenocysteine incorporation machinery in the nematode lineage. RNA 20(7):1023-1034.
  • Bonilla M, Denicola A, Marino SM, Gladyshev VN, Salinas G (2011) Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation. J Biol Chem 286(7):4959-4967.
  • Otero L, Bonilla M, Protasio AV, Fernández C, Gladyshev VN, Salinas G (2010) Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths. BMC Genomics 11(1):237-249.
  • Bonilla M, Denicola A, , Novoselov SV, Turanov AA, Protasio A, Izmendi D, Gladyshev VN, Salinas G (2008) Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem 283(26):17898-17907.
  • Romero H, Zhang Y, Gladyshev VN, Salinas G (2005) Evolution of selenium utilization traits. Genome Biol 6(8):R66.
  • Agorio A, Chalar C, Cardozo S, Salinas G (2003) Alternative mRNAs arising from trans-splicing code for mitochondrial and cytosolic variants of Echinococcus granulosus thioredoxin glutathione reductase. J Biol Chem 278(15):12920-12928.