Leticia Zarantonelli, PhD

Pateur + INIA Joint Unit

  • Postdoc in Physiopathology y Molecular pathogenesis of Neisseria meningitidis infection, Institut Pasteur Paris, France (2001 – 2006).
  • PhD in Chemistry, Faculty of Chemistry, University of the Republic, Montevideo Uruguay (1997 – 2000)
  • Biochemist, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina (1990 – 1996).
  • Microbiology
  • Host-pathogen interaction in bacteria that cause disease in man and/or animals
  • Antimicrobial resistance
  • Molecular typing of bacteria
  • Zarantonelli L, Suanes A, Meny P, Buroni F, Nieves C, Salaberry X, Briano C, Ashfield N, Da Silva Silveira C, Dutra F, Easton C, Fraga M, Giannitti F, Hamond C, Macías-Rioseco M, Menéndez C, Mortola A, Picardeau M, Quintero J, Ríos C, Rodríguez V, Romero A, Varela G, Rivero R, Schelotto F, Riet-Correa F, Buschiazzo A; Grupo de Trabajo Interinstitucional de Leptospirosis Consortium. Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis. PLoS Negl Trop Dis. 2018 Sep 13;12(9):e0006694. doi:10.1371/journal.pntd.0006694. eCollection 2018 Sep. PubMed PMID: 30212451; PubMed Central PMCID: PMC6136691.
  • Zarantonelli ML, Skoczynska A, Antignac A, El Ghachi M, Deghmane AE, Szatanik M, Mulet C, Werts C, Peduto L, d’Andon MF, Thouron F, Nato F, Lebourhis L,Philpott DJ, Girardin SE, Vives FL, Sansonetti P, Eberl G, Pedron T, Taha MK, Boneca IG. Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of Neisseria meningitidis. Cell Host Microbe. 2013 Jun 12;13(6):735-45. doi: 10.1016/j.chom.2013.04.016. PubMed PMID: 23768497.
  • Hill M, Deghmane AE, Segovia M, Zarantonelli ML, Tilly G, Blancou P, Bériou G, Josien R, Anegon I, Hong E, Ruckly C, Antignac A, El Ghachi M, Boneca IG, Taha MK, Cuturi MC. Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor. PLoS One. 2011;6(10):e23995. doi: 10.1371/journal.pone.0023995. Epub 2011 Oct. PubMed PMID: 22046231; PubMed Central PMCID: PMC3203111.
  • Zarantonelli ML, Lancellotti M, Deghmane AE, Giorgini D, Hong E, Ruckly C, Alonso JM, Taha MK. Hyperinvasive genotypes of Neisseria meningitidis in France. Clin Microbiol Infect. 2008 May;14(5):467-72. doi:10.1111/j.1469-0691.2008.01955.x. Epub 2008 Feb 22. PubMed PMID: 18294240.
  • Zarantonelli ML, Szatanik M, Giorgini D, Hong E, Huerre M, Guillou F, Alonso JM, Taha MK. Transgenic mice expressing human transferrin as a model for meningococcal infection. Infect Immun. 2007 Dec;75(12):5609-14. Epub 2007 Sep 24. PubMed PMID: 17893132; PubMed Central PMCID: PMC2168318.
  • Zarantonelli ML, Huerre M, Taha MK, Alonso JM. Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice. Infect Immun. 2006 Oct;74(10):5506-12. PubMed PMID: 16988225; PubMed Central PMCID: PMC1594929.
  • Zarantonelli ML, Antignac A, Lancellotti M, Guiyoule A, Alonso JM, Taha MK. Immunogenicity of meningococcal PBP2 during natural infection and protective activity of anti-PBP2 antibodies against meningococcal bacteraemia in mice. J Antimicrob Chemother. 2006 May;57(5):924-30. Epub 2006 Mar 2. PubMed PMID:16513914.
  • Zarantonelli L, Borthagaray G, Lee EH, Veal W, Shafer WM. Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae. J Antimicrob Chemother. 2001 May;47(5):651-4. PubMed PMID: 11328778.
  • Zarantonelli L, Borthagaray G, Lee EH, Shafer WM. Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations. Antimicrob Agents Chemother. 1999 Oct;43(10):2468-72. PubMed PMID: 10508026; PubMed Central PMCID: PMC89502.
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