Marcelo Hill

Marcelo Hill, MD, PhD

Inmunorregulation and Inflammation Laboratory

Education

Research areas

Patents

Relevant publications

Medical Doctor. 2002. Faculty of Medicine, University of the Republic. Montevideo, Uruguay.
Master in Biochemistry. 2002. PEDECIBA. Faculty of Science, University of the Republic. Montevideo, Uruguay.
PhD in Immunology. 2006. Nantes University, France.
Post-doctoral fellow. 2006-2012 at INSERM U643, Nantes, France.
G°3 Researcher PEDECIBA. Uruguay.
Associate Professor. Since 2010. Immunobiology Department. Faculty of Medicine, University of the Republic. Montevideo, Uruguay.
Associate Proffesor. 2010-2012. Odontology Faculty. Nantes University, France.
Level I Researcher. National Researchers System Uruguay.
Since 2013. Laboratory of Immunoregulation and Inflammation. Institut Pasteur de Montevideo. Head.
Since 2017. Centre for Translational Immunology. Institut Pasteur de Montevideo. FOCIS Centre of Excellence. Director.
Since 2018. Founder and Chief Scientific Officer of ARDAN ImmunoPharma.

US Provisional Patent application. Serial No. 62/500,113, Filed May 2nd 2017. Immunoresponsive Methods of Treating Tumors. Inventors: Marcelo Hill, Mercedes Segovia, Sofia Russo, Mathias Jeldres, Maria Romina Girotti, Yamil Mahmoud, Maite Duhalde, Maria Cristina Cuturi.
U.S. Patent Application No. 62/570,973, Filed October 11, 2017. Methods for Treating Tissue and Organ Transplant Rejection. Inventors: Carlos Batthyany, Virginia Lopez, Carlos Escande, Jorge Rodriguez, Williams Porcal, Rosina Dapueto, German Galliussi, Maria Pia Garat, Marcelo Hill, Mercedes Segovia, Ignacio Anegon, Maria Cristina Cuturi.
U.S. Patent Application No. 62/621,228, Filed January 24, 2018. Methods for Treating Heart Transplant Rejection. Inventors: Carlos Batthyany, Virginia Lopez, Carlos Escande, Jorge Rodriguez, Williams Porcal, Rosina Dapueto, German Galliussi, Maria Pia Garat, Marcelo Hill, Mercedes Segovia, Ignacio Anegon, Maria Cristina Cuturi.

Immunorregulation
Cancer
Dendritic cells
Immunotherapy

Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine. Schroeder ME, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogolín M, Zamboni DS, Ferreira G, Cairoli E, Hill M. Sci Rep. 2017 May 15;7(1):1892. doi: 10.1038/s41598-017-01836-8.
Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation. Mercedes Segovia, Cedric Louvet, Pierre Charnet, Ariel Savina, Gaelle Tilly, Laetitia Gautreau, Laura Carretero-Iglesia, Gaelle Beriou, Ignacio Cebrian, Thierry Cens, Lucy Hepburn, Elise Chiffoleau, Rodrigo Andres Floto, Ignacio Anegon, Sebastian Amigorena, Maria Cristina Cuturi and Marcelo Hill. Am J Transplant. 2014 May; 14(5):1021-31
Penicillin binding proteins as danger signals: meningococcal PBP2 activates DCs through TLR4. Marcelo Hill, Ala-Eddine Deghmane, Mercedes Segovia, Maria Leticia Zarantonelli, Gaëlle Tilly, Philippe Blancou, Régis Josien, Ignacio Anegon, Eva Hong, Corinne Ruckly, Aude Antignac, Meriem El Ghachi, Ivo Gomperts Boneca, Muhamed-Kheir Taha and Maria Cristina Cuturi. PLoS One. 2011; 6(10):e23995. Epub 2011 Oct 27.
Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through IFN-γ and EBI3. Marcelo Hill, Paméla Thebault, Mercedes Segovia, Cédric Louvet, Gaëlle Bériou, Gaëlle Tilly, Emmanuel Merieau, Ignacio Anegon, Elise Chiffoleau and Maria-Cristina Cuturi. Am J Transplant. 2011 Oct; 11(10):2036-45. doi: 10.1111/j.1600-6143.2011.03651.x.
Preparation of mouse bone marrow-derived dendritic cells with immuno-regulatory properties. Mercedes Segovia, Maria Cristina Cuturi and Marcelo Hill. Methods Mol Biol. 2011;677:161-8
IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Marcelo Hill, Séverine Tanguy-Royer, Pierre Royer, Christine Chauveau, Kashif Asghar, Frédéric Lavainne, Séverine Rémy, Régis Brion, François-Xavier Hubert, Michèle Heslan, Marie Rimbert, Laureline Berthelot, John Moffet, Régis Josien, Marc Grégoire and Ignacio Anegon. EurJ Immunol. 2007, 37 (11) 3054-62
Nitric oxide and indoleamine 2,3-dioxygenase mediate CTLA4Ig-induced survival of heart allografts in rats. Marcelo Hill, Rachid Zagani, Cécile Voisine and Ignacio Anegon. Transplantation. 2007, 84 (8) 1060-3
CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFN-γ and indoleamine 2,3-dioxygenase. Carole Guillonneau, Marcelo Hill, François-Xavier Hubert, Elise Chiffoleau, Caroline Hervé, Xiang-Liang Li, Michèlle Heslan, Claire Usal, Laurent Tesson, Séverine Ménoret, Abdelhadi Saoudi, Brigitte Le Mauff, Régis Josien, Maria Cristina Cuturi and Ignacio Anegon. J Clin Invest. 2007. 117 (4) 1096-106
Heme oxygenase-1 inhibits rat and human breast cancer cells proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. Marcelo Hill, Victoria Pereira, Christine Chauveau, Rachid Zagani, Séverine Remy, Laurent Tesson, Daniel Mazal, Luis Ubillos, Régis Brion, Mir Farzin Mashreghi, Katja Kotsch, John Moffett, Cornelia Doebis, Martina Seifert, Jorge Boczkowski, Eduardo Osinaga and Ignacio Anegon. FASEB J. 2005 19: 14 1957-68
Immunobiological characterization of N-Nitrosomethylurea-induced rat breast carcinomas: tumoral IL-10 expression as a possible immune escape mechanism. Hill M, Bausero MA, Mazal D, Ménoret S, Anegon I and Osinaga E. Breast Cancer Research and Treatment. 2004 Mar. 84; 2; 107-16