Nicolás Sarute

Nicolás Sarute, PhD

Laboratory of
Virus-Cell Interactions

  • Postdoctoral Researcher in Virus-Host Interactions. Department of Microbiology, School of Medicine, University of Pennsylvania (2015-2016); Department of Microbiology and Immunology, School of Medicine, University of Illinois at Chicago (2016-2020).
  • Doctor in Biological Sciences Genetic Option, PEDECIBA. Evolutionary Genetics Section, Faculty of Sciences, UdelaR in collaboration with the Viral Populations and Pathogenesis laboratory, Institut Pasteur Paris (2012-2014)
  • MSc. in Biological Sciences Genetic Option, PEDECIBA. Evolutionary Genetics Section, Faculty of Sciences, UdelaR (2008-2011).
  • Degree in Biological Sciences Deepening in Genetics, Faculty of Science, UdelaR (2003-2008).
  • Cell virology
  • Signal transduction
  • Antiviral immune response
  • Sarute N, Cheng H, Yan Z, Salas-Briceno K, Richner J, Rong L, Ross SR (2021). Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. PLoS Pathog. 17(6):e1009662. https://doi.org/10.1371/journal.ppat.1009662
  • Sarute N, Ross SR (2021). The board is set, the pieces are moving: Modulation of New World arenavirus entry by host proteins. PLoS Pathog. 17(6):e1009605. https://doi.org/10.1371/journal.ppat.1009605
  • Sarute N, Ross SR (2020). CACNA1S haploinsufficiency confers resistance to New World arenavirus infection. Proc Natl Acad Sci USA. 117(32): 19497-19506. https://doi.org/10.1073/pnas.1920551117.
  • Li* JJ, Sarute* N, Lancaster E, Otkiran-Clare G, et al (2020). A recessive Trim2 mutation causes an axonal neuropathy in mice. Neurobiol Dis, 140:104845. https://doi.org/10.1016/j.nbd.2020.104845. *Co-first
  • Sarute N, Ibrahim N, Medegan Fagla B, et al (2019). TRIM2, a novel member of the antiviral family, limits new world arenavirus entry. PLoS Biol 17 (2): e3000137. https://doi.org/10.1371/journal.pbio.3000137.
  • Sarute N, Ross SR (2017). New World Arenavirus Biology. Annual Reviews of Virology, 4(1):141-158. doi: 10.1146/annurev-virology-101416-042001.
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