José Badano
Executive Director
Laboratory of
Molecular and Human Genetics
- Posdoc. Genetics and Functional Characterization of the Cilia Proteome, Johns Hopkins University, Baltimore, MD, USA (2004 – 2007).
- PhD in Molecular and Human Genetics. Baylor College of Medicine, Houston, Texas, USA (2004).
- B.S. in Science Biology, Faculty of Science, University of the Republic, Uruguay (1997).
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Guggeri L, Sosa-Redaelli I, Cárdenas-Rodríguez M, Alonso M, González G, Naya H, Prieto-Echagüe V, Lepanto P, Badano JL (2024) Follistatin like-1 (Fstl1) regulates adipose tissue development in zebrafish. Adipocyte 13(1):2435862. doi: 10.1080/21623945.2024.2435862.
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Fabregat M, Niño-Rivero S, Pose S, Cárdenas-Rodríguez M, Bresque M, Hernández K, Prieto-Echagüe V, Schlapp G, Crispo M, Lagos P, Lago N, Escande C, Irigoín F, Badano JL (2022) Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with mild social behavioral phenotypes. PLoS Genet 18(6):e1009896. doi: 10.1371/journal.pgen.1009896.
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Lepanto P, Levin-Ferreyra F, Koziol U, Malacrida L, Badano JL (2021) Insights into in vivo adipocyte differentiation through cell-specific labeling in zebrafish. Biol Open 10(9):bio058734. doi: 10.1242/bio.058734.
- Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, González-Sapienza G, Irigoín F, Badano JL (2018) Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Sci Rep 8:3019.
- Prieto-Echagüe V, Lodh S, Colman L, Bobba N, Santos L, Katsanis N, Escande C, Zaghloul NA, Badano JL (2017) BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1. Scientific Reports 7(1): 9765.
- Torrado B, Graña M, Badano JL, Irigoín F (2016) Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-Independent. PLoS One 11:e0162033.
- Lepanto P, Davison C, Casanova G, Badano JL, Zolessi FR (2016) Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish. Neural Dev 11:10.
- Cardenas-Rodriguez M, Irigoín F, Osborn DP, Gascue C, Katsanis N, Beales PL, Badano JL (2013) The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex. Hum Mol Genet 22:4031-42.
- Gascue C, Tan PL, Cardenas-Rodriguez M, Libisch G, Fernandez-Calero T, Liu YP, Astrada S, Robello C, Naya H, Katsanis N, Badano JL (2012) Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation. J Cell Sci 125:362-75.
- Badano JL, Leitch CC, Ansley SJ, May-Simera H, Lawson S, Lewis RA, Beales PL, Dietz HC, Fisher S, Katsanis N (2006) Dissection of epistasis in oligogenic Bardet-Biedl syndrome. Nature 439:326-30.
- Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR, Katsanis N, Beales PL (2004) The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 36:462-70.
- Ansley SJ, Badano JL, Blacque OE, Hill J, Hoskins BE, Leitch CC, Kim JC, Ross AJ, Eichers ER, Teslovich TM, Mah AK, Johnsen RC, Cavender JC, Lewis RA, Leroux MR, Beales PL, Katsanis N (2003) Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425:628-33.
- Katsanis N, Ansley SJ, Badano JL, Eichers ER, Lewis RA, Hoskins BE, Scambler PJ, Davidson WS, Beales PL, Lupski JR (2001) Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder. Science 293:2256-9.
- Human Genetics.
- Bardet-Biedl syndrome (BBS).
- Ciliopathies.
- Cilia.
José L. Badano Caballero
Brief review
He holds a B.Sc. in Biological Sciences from the Faculty of Sciences at the Universidad de la República (Uruguay) and a Ph.D. in Human Molecular Genetics from Baylor College of Medicine (Houston, TX, USA), which he pursued with the support of a Fulbright Scholarship. He completed his postdoctoral training at the Institute of Medical Genetics at Johns Hopkins University (Baltimore, MD, USA). His research has focused on ciliopathies, a group of human diseases caused by defects in cellular organelles known as cilia, investigating these conditions at the genetic, cellular, and molecular levels. His primary research model has been Bardet-Biedl syndrome. He currently heads the Human Molecular Genetics (GMH) Laboratory and serves as Executive Director of the Institut Pasteur de Montevideo. He has authored approximately 50 scientific papers published in peer-reviewed international journals, as well as book chapters. He is a member of the Academy of Sciences of Latin America (ACAL) and The World Academy of Sciences (TWAS), and a Level II researcher in Uruguay’s National System of Researchers (SNI).
Work history
- Ph.D., Baylor College of Medicine, Houston, TX, USA (1999–2004).
- Fulbright Grantee, Institute of International Education, sponsored by the United States Information Agency (1999–2001).
- Postdoctoral Fellow, Institute of Medical Genetics, Johns Hopkins University, Baltimore, MD, USA (2004–2007).
- Postdoctoral Fellowship, PKD Foundation, USA (2004–2007).
- Young Group Leader (G5), Institut Pasteur de Montevideo, Uruguay (2007–2011).
- Principal Investigator and Head of the Human Molecular Genetics (GMH) Laboratory, Institut Pasteur de Montevideo, Uruguay (2011–present).
- Researcher, Basic Sciences Development Program (PEDECIBA), Uruguay (2007–present). Currently at Grade 5.
- Active Member, National System of Researchers (SNI), Level II, Uruguay (2009–present).
- Full Professor, Universidad ORT Uruguay, Montevideo, Uruguay (2011–present).
- Board Member, Uruguayan Society of Biosciences (SUB), Uruguay (2013–2017).
- Academic Director, Institut Pasteur de Montevideo, Uruguay (2020–2026).
- Executive Director, Institut Pasteur de Montevideo, Uruguay (2026–present).