José Badano

José Badano, PhD

Academic Director

Laboratory of
Molecular and Human Genetics

  • Posdoc. Genetics and Functional Characterization of the Cilia Proteome, Johns Hopkins University, Baltimore, MD, USA (2004 – 2007).
  • PhD in Molecular and Human Genetics. Baylor College of Medicine, Houston, Texas, USA (2004).
  • B.S. in Science Biology, Faculty of Science, University of the Republic, Uruguay (1997).
  • Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, González-Sapienza G, Irigoín F, Badano JL (2018) Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Sci Rep 8:3019.
  • Prieto-Echagüe V, Lodh S, Colman L, Bobba N, Santos L, Katsanis N, Escande C, Zaghloul NA, Badano JL (2017) BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1. Scientific Reports 7(1): 9765.
  • Torrado B, Graña M, Badano JL, Irigoín F (2016) Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-Independent. PLoS One 11:e0162033.
  • Lepanto P, Davison C, Casanova G, Badano JL, Zolessi FR (2016) Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish. Neural Dev 11:10.
  • Cardenas-Rodriguez M, Irigoín F, Osborn DP, Gascue C, Katsanis N, Beales PL, Badano JL (2013) The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex. Hum Mol Genet 22:4031-42.
  • Gascue C, Tan PL, Cardenas-Rodriguez M, Libisch G, Fernandez-Calero T, Liu YP, Astrada S, Robello C, Naya H, Katsanis N, Badano JL (2012) Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation. J Cell Sci 125:362-75.
  • Badano JL, Leitch CC, Ansley SJ, May-Simera H, Lawson S, Lewis RA, Beales PL, Dietz HC, Fisher S, Katsanis N (2006) Dissection of epistasis in oligogenic Bardet-Biedl syndrome. Nature 439:326-30.
  • Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR, Katsanis N, Beales PL (2004) The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 36:462-70.
  • Ansley SJ, Badano JL, Blacque OE, Hill J, Hoskins BE, Leitch CC, Kim JC, Ross AJ, Eichers ER, Teslovich TM, Mah AK, Johnsen RC, Cavender JC, Lewis RA, Leroux MR, Beales PL, Katsanis N (2003) Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425:628-33.
  • Katsanis N, Ansley SJ, Badano JL, Eichers ER, Lewis RA, Hoskins BE, Scambler PJ, Davidson WS, Beales PL, Lupski JR (2001) Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder. Science 293:2256-9.
  • Human genetics
  • Bardet-Biedl Syndrome (BBS)
  • Ciliopathies
  • Cilia
José L. Badano Caballero, 49 years old (1972), married and father of three children

Brief review
Degree in Biological Sciences, Faculty of Sciences, University of the Republic, Uruguay, with a Ph.D. in Human Molecular Genetics from Baylor College of Medicine, Houston, TX, USA, for which he obtained a Fulbrigt Scholarship. Postdoctoral fellow at the Johns Hopkins University Institute of Medical Genetics, Baltimore, MD, USA. His work has focused on the genetic, cellular and molecular study of ciliopathies, a group of human diseases caused by defects in a cellular organelle called cilia. Among them, the main study model has been Bardet-Biedl syndrome. He currently directs the Human Molecular Genetics Laboratory (GMH) at the Institut Pasteur de Montevideo. He has published more than 40 scientific papers in international peer-reviewed journals as well as book chapters. Member of the Latin American Academy of Sciences (ACAL) and The World Academy of Sciences (TWAS).

Work history

  • Doctorate, Baylor College of Medicine, Houston, TX, USA (1999 to 2004).
  • Fulbright Scholar, Institute of International Education, sponsored by the United States Information
    Agency (1999-2001).
  • Postdoctoral Fellow at the Institute of Medical Genetics, Johns Hopkins University, Baltimore, MD,
    USA (2004 to 2007).
  • Postdoctoral Fellowship awarded by the Polycystic Kidney Disease Foundation (PKD Foundation),
    USA (2004 to 2007).
  • Young Group Leader (G5), Institut Pasteur de Montevideo, Uruguay (2007 to 2011).
  • Principal Investigator and Head of the Laboratory of Human Molecular Genetics (GMH), Institut
    Pasteur de Montevideo, Uruguay (2011 to date).
  • Researcher Grade 4 of the Programme for the Development of Basic Sciences (PEDECIBA), Uruguay (2007
    to date).
  • Active member of the National System of Researchers (SNI) (Level 2), Uruguay (2009 to date).
  • Full Professor, Universidad ORT, Montevideo, Uruguay (2011 to date).
  • Board of Directors of the Uruguayan Society of Biosciences (SUB), Uruguay (2013 – 2017).
  • Academic Director, Institut Pasteur de Montevideo, Uruguay (2020 to date).